Results 71 to 80 of about 37,562 (240)

Micronuclei with multiple copies of the X chromosome: do chromosomes replicate in micronuclei? [PDF]

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2004
The formation of a micronucleus due to chromosome lagging is a well known mechanism of chromosomal loss. However, the post-mitotic fate of the micronucleus and the chromosomal DNA within it is poorly understood. We observed micronuclei (MN) that had multiple copies of the X chromosome (ranging from 4 to 10) when analyzing cultured human lymphocytes ...
Natalia Tszine, Leach, Colleen, Jackson-Cook   +1 more
openaire   +2 more sources

The Impact of Genotoxicity in Coke Oven Workers: Systematic Review With Meta‐Analysis

Journal of Applied Toxicology, EarlyView.
ABSTRACT This systematic review (SR) with meta‐analysis investigates the genotoxicity potential of coke oven workers (COWs) exposed to polycyclic aromatic hydrocarbons (PAHs) through a comprehensive analysis of studies retrieved from PubMed, SCOPUS, and Web of Science.
Thiago Guedes Pinto, Vinícius Fialho do Nascimento, Giovanna Abreu Holanda Guerra, Wilton Mitsunari Takeshita, Raquel Alves Sales, Andrea Cristina de Moraes Malinverni, Luciana Lopes Guimaraes, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Long-term safety evaluation of doum fruit (Hyphaene thebaica L.) aqueous extract on the female reproductive parameters, fetal formations and mutagenic potential [PDF]

Brazilian Journal of Biology
Several studies have been reported about the distinct activity of the doum fruits as hypotensive, anti-diabetic, antimicrobial, antioxidants and hypolipidemic.
I. M. El-Ashmawy, A. E. Bayad, A. S. Soliman, W. Al Abdulmonem, A. S. M. Aljohani   +4 more
doaj   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

Bisphenol A Induces DNA Damage and Differential Cytotoxicity in Thyroid Cells: High‐Dose Effects Challenge Regulatory Thresholds

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been implicated in carcinogenesis; however, its effects on thyroid cells remain unclear. This study investigated BPA‐induced cytotoxicity and genotoxicity in thyroid cell lines, including normal follicular (Nthy‐ori 3‐1), papillary carcinoma (TPC‐1 and BCPAP) and anaplastic
Izabela Fernanda Dal' Bó, Natássia Elena Bufalo, Valdemar Máximo, Laura Sterian Ward   +3 more
wiley   +1 more source

Comparative evaluation of genotoxicity in tobacco users versus nontobacco users

Journal of Pharmacy and Bioallied Sciences, 2021
Background: Many of the contents of cigarette smoke are genotoxic in nature, and consequently, cytogenetic injury seems to be a trustworthy biomarker for deciding the influence of exposure to chromosome damaging agents in smoke.
Arun Jacob Thomas, Bindu J Nair, Sajna Oommen, V Syamkumar, Resmi K Raman   +4 more
doaj   +1 more source

Biomonitoring of the genotoxic potential (micronucleus assay) and detoxifying activity (EROD induction) in the River Dadou (France), using the amphibian Xenopus laevis [PDF]

, 2004
Within the framework of a general survey of the water quality of the river Dadou (Tarn, France), different physicochemical parameters were measured and an inventory of the fish population was made along the water course, around the Rassisse dam.With the ...
Gauthier, Laury, Marty, Josette, Mouchet, Florence, Tardy, Emmanuelle   +3 more
core   +2 more sources

Mitotic clustering of pulverized chromosomes from micronuclei

Nature, 2023
Abstract Complex genome rearrangements can be generated by the catastrophic pulverization of missegregated chromosomes trapped within micronuclei through a process known as chromothripsis 1–5 .
Yu-Fen Lin, Qing Hu, Alice Mazzagatti, Jose Espejo Valle-Inclán, Elizabeth G. Maurais, Rashmi Dahiya, Alison Guyer, Jacob T. Sanders, Justin L. Engel, Giaochau Nguyen, Daniel Bronder, Samuel F. Bakhoum, Isidro Cortés-Ciriano, Peter Ly   +13 more
openaire   +3 more sources

Cellular Responses to Tartrazine and Sulfanilic Acid Exposure in BEAS‐2B Cells: Viability, Apoptosis, and DNA Damage

Journal of Applied Toxicology, EarlyView.
ABSTRACT Tartrazine is a synthetic azo dye widely used in food, pharmaceutical, and cosmetic products, resulting in extensive human exposure, while its toxicity and that of its primary metabolite, sulfanilic acid, remain controversial. Considering the reported association of tartrazine with hypersensitivity and allergic‐like reactions, human bronchial ...
Merve Baysal, Abdullah Burak Karaduman, Büşra Korkut Çelikateş, Merve Güven, Özlem Atlı‐Eklioğlu, Sinem Ilgın   +5 more
wiley   +1 more source

Meiotic irregularities in Alstroemeria andina var. Venustula (Alstroemeriaceae) [PDF]

, 2007
Alstroemeria andina Phil. var. venustula (Phil.) M. Muñoz (sub nom. A. andina Phil. subsp. venustula (Phil.) Ehr. Bayer) is a perennial, small herb, 5-16 cm tall, that occurs mainly at 2,800-3,700 meters above sea level, in populations of limited ...
Sanso, Andrea Mariel, Wulff, Arturo Federico   +1 more
core