Results 81 to 90 of about 32,768 (229)

WR-2721: Inhibitor of cisplatin-induced micronuclei

Teratogenesis, Carcinogenesis, and Mutagenesis, 2000
The modulatory effect of S-2-/3-aminopropylamino/ethyl-phosphorothioic acid, (WR-2721, Amifostine) on induction of micronuclei by cis-diamminedichloroplatinum[II] (CDDP) was studied. The adult, male Swiss mice were treated with WR-2721, at a dose of 200 mg/kg or 400 mg/kg body weight, and/or with CDDP, at a dose 5 mg/kg or 10 mg/kg body weight. WR-2721
Mazur, Lidia, Czyżewska, Agnieszka, Augustynek, Anna   +2 more
openaire   +3 more sources

Cytomorphological changes of oral mucosal cells among smokeless tobacco users in low and middle-income country settings: new findings from Pakistan

BMC Oral Health
Background Chronic tobacco use, in any form, induces significant cellular alterations in the oral mucosa. This study investigates four distinct cytomorphological changes in oral mucosal cells among smokeless tobacco users, examining their association ...
Sabreen Hassan, Ayesha Sifat, Mohammad Munib, Saleha Saeed, Waqar U. Nisa, Sofia Haider Durrani, Abid Rahim, Naeem Ullah, Saima Afaq, Farhad Ali Khattak, Zia Ul Haq   +10 more
doaj   +1 more source

ROS-mediated genotoxicity of asbestos-cement in mammalian lung cells in vitro

Particle and Fibre Toxicology, 2005
Asbestos is a known carcinogen and co-carcinogen. It is a persisting risk in our daily life due to its use in building material as asbestos-cement powder.
Rödelsperger Klaus, Rauen Ursula, von Recklinghausen Ursula, Bhattacharya Kunal, Ansari Furquan, Yadav Santosh, Dopp Elke, Shokouhi Behnaz, Geh Stefan, Rahman Qamar   +9 more
doaj   +1 more source

Micronuclei as a predictor for oral carcinogenesis

Journal of Cytology, 2018
The aim of the study was to provide a quantitative evaluation of oral mucosal micronuclei (MN) frequency as a biomarker for oral cancer susceptibility in carcinogenesis progression.60 patients were included in the study. 30 patients with biopsy proven epithelial dysplasia (ED, 15) and oral squamous cell carcinoma (OSCC, 15) comprised the study group ...
Kamini Kiran, Padmanidhi Agarwal, Shailesh Kumar, Kanav Jain   +3 more
openaire   +3 more sources

Chromosomes missegregated into micronuclei contribute to chromosomal instability by missegregating at the next division

OncoTarget, 2019
Micronuclei (MNi) are extranuclear DNA-containing structures that form upon mitotic exit from unsegregated chromosome fragments or anaphase lagging (whole) chromosomes (LCs).
Bin He, Nisha Gnawali, A. Hinman, A. Mattingly, Alyssa M Osimani, D. Cimini   +5 more
semanticscholar   +1 more source

In Vitro and In Vivo Genotoxicity of Polystyrene Microplastics: Evaluation of a Possible Synergistic Action with Bisphenol A

Journal of Xenobiotics
The ubiquitous presence of plastics represents a global threat for all ecosystems and human health. In this study, we evaluated, in vitro and in vivo, the genotoxic potential of different concentrations of polystyrene microplastics (PS-MPs) and their ...
Alfredo Santovito, Mattia Lambertini, Alessandro Nota   +2 more
doaj   +1 more source

Influence of the radiation on cytogenetic parameters mouselike rodents from the Chornobyl Nuclear Power Plant exclusion zone [PDF]

Ядерна фізика та енергетика, 2013
Results of radioecological and cytogenetic studies are presented. The soil contamination on the testing exper-imental sites of Chornobyl exclusion zone was studied.
O. O. Burdo, A. I. Lypska, V. I. Nikolaev, V. A. Shytiyk, N. V. Kulisch   +4 more
doaj  

ER-directed TREX1 limits cGAS activation at micronuclei.

Molecules and Cells, 2021
L. Mohr, Eléonore Toufektchan, P. von Morgen, Kevan Chu, Aakanksha R. Kapoor, J. Maciejowski   +5 more
semanticscholar   +1 more source

Chromosomes trapped in micronuclei are liable to segregation errors

Journal of Cell Science, 2018
DNA in micronuclei is likely to get damaged. When shattered DNA from micronuclei gets reincorporated into the primary nucleus, aberrant rearrangements can take place, a phenomenon referred to as chromothripsis.
Mar Soto, I. García-Santisteban, L. Krenning, R. Medema, J. Raaijmakers   +4 more
semanticscholar   +1 more source

Chemoprotective effect of cysteamine against the induction of micronuclei by methyl methanesulfonate and cyclophosphamide

Genetics and Molecular Biology, 2005
Cysteamine or 2-mercaptoethylamine (MEA) is an aminothiol with a well-known radioprotective action. No specific information is available in the literature about the possible chemoprotective action of MEA against genotoxic chemical agents.
Renato Santos-Mello, Luiz Irineu Deimling, Claudio Lauer Júnior, Thaís Rieger de Carvalho   +3 more
doaj   +1 more source