Results 81 to 90 of about 37,562 (240)

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Giant cell formation produced by laser microbeam irradiation of chromatin in Chinese hamster cells [PDF]

, 1981
A pulsed laser microbeam of wavelength 532 nm was used to produce visible small lesions in the nucleoplasm or in the cytoplasm of V79 Chinese hamster cells.
Altmann, Berns, Berns, Berns, Berns, Berns, Berns, Berns, Berns, Berns, Burkhardt, Cain, Cremer, Cremer, Cremer, Cremer, Dreher, Factor, Geisinger, Hetzel, Kitzes, Leder, Leuchtenberger, Meredith, Moreno, Nakanishi, Peterson, Rattner, Schneider, Scott, Stevenson, Strahs, Tam, Tchakhotine, Wang   +34 more
core   +2 more sources

What do human micronuclei contain? [PDF]

Mutagenesis, 2003
As micronuclei (MN) derive from chromosomal fragments and whole chromosomes lagging behind in anaphase, the MN assay can be used to show both clastogenic and aneugenic effects. The distinction between these phenomena is important, since the exposure studied often induces only one type of MN.
Hannu, Norppa, Ghita C-M, Falck
openaire   +2 more sources

Safety of 12‐Months Administration of Ashwagandha (Withania somnifera) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve, Sanjeev Kale, Banwari Lal Prajapati, Adele Sparavigna, Mark Savant, John Ademola, Deepak Langade   +6 more
wiley   +1 more source

The cytogenetic parameters of Pinus sylvestris L. under conditions of the Far North of Russia (Karelia)

Folia Oecologica, 2022
The cytogenetic analysis of the Pinus sylvestris L. seed progeny in the forests of the northern taiga in the Far North of Russia conditions was carried out.
Ignatenko Roman Viktorovich, Efimova Lyubov Alexandrovna, Nikerova Ksenia Mikhailovna   +2 more
doaj   +1 more source

MICRONUCLEI: A PROGNOSTIC TOOL

Journal of Evolution of Medical and Dental Sciences, 2014
Squamous cell carcinoma is one the most common oral mucosal malignant tumor, diagnosis of oral squamous cell carcinoma rarely presents difficulty, it is the cancer staging and histo pathological grading that are more important for prognosis, micronuclei are good prognostic indicator. Micronuclei screening can be done easily by exfoliative cytology, one
Ankit Agarwal, Rinky Ahuja, Manisha Tijare, Sonalika Ghate, Anand Tegginamani, Sanyog Pathak   +5 more
openaire   +1 more source

Ecotoxicological Evaluation of Organic Sunscreens Used Worldwide, Alone and in Mixture, on Terrestrial Plants

Environmental Toxicology, EarlyView.
ABSTRACT The environmental hazards of sunscreens are discussed worldwide. However, there are few ecotoxicological studies on these compounds alone for edaphic organisms, and none for their mixtures. Avobenzone (1 and 10 ng/L), octocrylene (10 and 100 μg/L), and oxybenzone (2 and 20 μg/L), alone and in binary combinations (between the lowest and the ...
Diego Espirito Santo, Edson Araújo de Almeida, Elisângela Dusman, A. C. Downs, Regiane da Silva Gonzalez, Osvaldo Valarini Junior, Ana Paula Peron   +6 more
wiley   +1 more source

Radiation-Induced Chromosomal Aberrations and Immunotherapy: Micronuclei, Cytosolic DNA, and Interferon-Production Pathway

Frontiers in Oncology, 2018
Radiation-induced chromosomal aberrations represent an early marker of late effects, including cell killing and transformation. The measurement of cytogenetic damage in tissues, generally in blood lymphocytes, from patients treated with radiotherapy has ...
Marco Durante, Silvia C. Formenti
doaj   +1 more source

Seven benzimidazole pesticides combined at sub-threshold levels induce micronuclei in vitro [PDF]

, 2013
This article is made available through the Brunel Open Access Publishing Fund. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/), which
Aardema, Altenburger, Andreas Kortenkamp, Antoccia, Backhaus, Bentley, Berenbaum, Bianchi-Santamaria, Bliss, Bonatti, Castelain, Clare, COM., Davidse, Decordier, Diaz, Dolara, Drescher, Efron, EFSA., Elhajouji, Elhajouji, Ermler, Faust, Fellows, Fenech, Friedman, Graillot, Hashimoto, Hollomon, Kirkland, Kirsch-Volders, Kortenkamp, Loewe, Lorge, Lutz, Lutz, Marshall, Martin Scholze, Mosmann, OECD., Phelps, Ramírez, Ramírez, Santovito, Scholze, Sibylle Ermler, Sternes, Surrallés, Van Hummelen, Varga   +50 more
core   +1 more source

Titanium Detected in Liver, Kidney, Spleen, and Intestine Is Not Related to Dose, Time, or Route of Exposure to Titanium Dioxide: A Systematic Review

Environmental Toxicology, EarlyView.
ABSTRACT Titanium dioxide (TiO2), used as a food additive (labeled E171 in Europe), was withdrawn from the European market in 2022. The E171 toxicity mechanism involves its uptake, oxidative stress, DNA damage, and inflammation. It has been hypothesized that the TiO2 accumulation nanoparticles (NPs) or E171 triggers tissue damage, and some studies have
Carmen Ximena Martínez‐Escutia, Estefany I. Medina‐Reyes, Eduardo Delgado‐Armenta, Yolanda I. Chirino   +3 more
wiley   +1 more source