Results 21 to 30 of about 59,469 (309)

Analysing the Radioprotective Effect of Cotoneaster Nummularia in Mouse Bone Marrow Cells Using Micronucleus Assay [PDF]

Journal of Cell and Molecular Research, 2009
Study of the different aspects of protection against the exposure of ionizing radiation has always been an active area of research. High cost and toxicity of radioprotective drugs have limited their use.
Farhang Haddad, Ali Moghimi, Abbas Salmani, Mohammad Farhad Rahimi, Mohammad Reza Gawam-Nasiri   +4 more
doaj   +1 more source

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation [PDF]

, 2016
Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes of BRCA1 mutation carriers is counterintuitive, since BRCA1 is active in the
A Pijpe, A Vral, Anne Vral, Annelot Baert, B Ernestos, Bruce Poppe, D Goldfrank, E Febrer, EKJ Pauwels, EM John, F Cardinale, FJ Couch, Fransiska Malfait, G Sioftanos, GE Pantelias, Gianpaolo Perletti, GJ Heyes, H Nikjoo, I Cousineau, IM Obdeijn, J Barwell, J Depuydt, J Gronwald, J Lecarpentier, JC Drooger, JC Théry, Jenneke van den Ende, JL Bernheim, JM Hair, Julie Depuydt, K Claes, K Claes, K Claes, K Leeneer De, Kathleen B. M. Claes, Katrien Storm, KE Rieger, Kim De Leeneer, KW Caestecker, L Perrin-Vidoz, L Salmena, M Frankenberg-Schwager, M Sedic, ME Dextraze, MS Sasaki, N Andrieu, N Foray, N Li, O Anczuków, O Popanda, P Pfeiffer, P Willems, R Roy, RI Yarden, RJ Linger, S Gutiérrez-Enríquez, S Pathania, SA Narod, Sylvia De Nobele, T Vaclová, TA Buchholz, Tim Van Damme, Tom Van Maerken, U Hagen, V Giannakeas, WD Foulkes, Z Guo, Z Kote-Jarai   +67 more
core   +4 more sources

Effect of 5,6,7,8-Tetrahydrobiopterin (BH4) on γ-Ray-induced Micronucleus Frequency in RAW264.7 Cells

Pteridines, 2006
The effect of 5,6,7,8-tetrahydrobiopterin (BH4), an endogenous antioxidant, on γ-ray-induced micronucleus frequency was examined in RAW264.7 cells. Exogenously added BH4 reduced the γ-ray-induced micronucleus frequency. Treatment with 1 mM sepiapterin, a
Hori Mayumi, Kojima Shuji
doaj   +1 more source

Genotoxicity of 22% Carbamide Peroxide Bleaching Agent on Oral Cells using the Micronucleus Technique [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Several bleaching products and methods were introduced over the last years. However, the consequences of 22% carbamide peroxide on the genetic material of oral mucosal cells is uncertain.
Laís Vargas Bonacina, Carolina do Amaral Vargas, Julia Vanini, Júlia Zandoná, Rodrigo Rohenkohl Silvlva, Carmen Silvlvia Busin, Paula Benetti, João Paulo De Carli   +7 more
doaj   +1 more source

In the screening of alternative insecticides to control Aedes aegytpti larvae 2-methylanthraquinone showed no genotoxicity and low toxicity to zebrafish (Danio rerio) [PDF]

Genetics and Molecular Biology, 2022
The threats posed by insecticide resistance to Aedes aegypti in the context of controlling dengue have led to an urgent search for an environmentally safer alternative chemical with more effective larvicidal properties.
Tathyana Benetis Piau, Maria Luiza Fascineli, Diego Sousa Moura, Lorena Carneiro Albernaz, Laila Salmen Espindola, Cesar Koppe Grisolia   +5 more
doaj   +1 more source

ATR-FTIR spectroscopy detects alterations induced by organotin(IV) carboxylates in MCF-7 cells at sub-cytotoxic/-genotoxic concentrations. [PDF]

, 2008
The environmental impact of metal complexes such as organotin(IV) compounds is of increasing concern. Genotoxic effects of organotin(IV) compounds (0.01 μg/ml, 0.1 μg/ml or 1.0 μg/ml) were measured using the alkaline single-cell gel electrophoresis ...
Ahmad, Muhammad S., Ali, Saqib, Hanif, Muhammad, Hussain, Mukhtiar, Martin, Frank L., Mirza, Bushra, Walsh, Michael J.   +6 more
core   +3 more sources

Datasets Construction and Development of QSAR Models for Predicting Micronucleus In Vitro and In Vivo Assay Outcomes

Toxics, 2023
In silico (quantitative) structure–activity relationship modeling is an approach that provides a fast and cost-effective alternative to assess the genotoxic potential of chemicals.
Lusine Khondkaryan, Ani Tevosyan, Hayk Navasardyan, Hrant Khachatrian, Gohar Tadevosyan, Lilit Apresyan, Gayane Chilingaryan, Zaven Navoyan, Helga Stopper, Nelly Babayan   +9 more
doaj   +1 more source

Evaluation of the genotoxic and teratogenic potential of a municipal sludge and sludge-amended soil using the amphibian Xenopus laevis and the tobacco: Nicotiana tabacum L. var. xanthi Dulieu [PDF]

, 2003
The toxic, genotoxic and teratogenicpotential of amunicipal sewage sludge was assessed using the micronucleus assay on the larvae of the amphibianXenopuslaevis and with the tobacco somatic mutation test using the yellow–green xanthiDulieu mutant a1+/a1 ...
Chenon, Pascale, Delpoux, Marcel, Gauthier, Laury, Loubières, Pascale, Séverac, Alain   +4 more
core   +4 more sources

Effect of Phenol Derivatives in the Oral Mucosa of University Laboratory Technicians

Brazilian Archives of Biology and Technology, 2023
The objective of the present work was to quantify the effect of phenolic derivatives on in the oral mucosa of university laboratory technicians. Twenty (20) university laboratory technicians exposed to agents and 11 non-smokers without occupational ...
Ana Paula Nogueira Ferri, Bruna Gomide, Fellipe Augusto Tocchini de Figueiredo, Celina Faig Lima Carta, Ivan Balducci, Janete Dias Almeida   +5 more
doaj   +1 more source

Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from municipal solid waste incineration, using the comet and micronucleus tests on amphibian (Xenopus laevis) larvae and bacterial assays (MutatoxR and Ames tests) [PDF]

, 2006
The management of contaminated soils and wastes is a matter of considerable human concern. The present study evaluates the genotoxic potential of aqueous extracts of two soils (leachates) and of bottom ash resulting from municipal solid waste ...
Devaux, Alain, Ferrier, Vincent, Gauthier, Laury, Jourdain, Marie-José, Mailhes, Corinne, Mouchet, Florence, Triffault, Gaëlle   +6 more
core   +2 more sources