Results 81 to 90 of about 38,648 (228)

Germ Line-Specific DNA Sequences are Present on All Five Micronuclear Chromosomes in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]

, 1983
The development of the macronucleus from the zygotic micronucleus in the ciliated protozoan Tetrahymena spp. involves the elimination of specific DNA sequences (M. C. Yao and M. Gorovsky, Chromosoma 48:1-18 1974).
Karrer, Kathleen M.
core   +1 more source

Lead-induced genotoxicity to Vicia faba L.roots in relation with metal cell uptake and initial speciation [PDF]

, 2011
Formation of organometallic complexes in soil solution strongly influence metals phytoavailability. However, only few studies deal with the influence of metalspeciation both on plant uptake and genotoxicity. In the present study, Viciafaba seedlings were
Dumat, Camille, Pinelli, Eric, Pourrut, Bertrand, Shahid, Muhammad, Silvestre, Jérôme   +4 more
core   +3 more sources

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Assessment of the genotoxicity of Cu and Zn in raw and anaerobically digested slurry with the Vicia faba micronucleus test [PDF]

, 2009
Genotoxicity of Cu and Zn was assessed by use of the micronucleus (MN) test on Vicia faba roots. Plants were exposed to various leachates of rawand anaerobically digested pig slurry, with maximum total concentrations of 200MCu and 600MZn.
Guiresse, Agnès Maritchù, Marcato, Claire-Emmanuelle, Pinelli, Eric, Pourrut, Bertrand, Silvestre, Jérôme   +4 more
core   +3 more sources

Safety of 12‐Months Administration of Ashwagandha (Withania somnifera) Standardized Root Extract in Healthy Adults: A Prospective, Observational Study

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve, Sanjeev Kale, Banwari Lal Prajapati, Adele Sparavigna, Mark Savant, John Ademola, Deepak Langade   +6 more
wiley   +1 more source

The Protective Effects of Origanum vulgare L. Extract on Genetic Damage of Cyclophosphamide in Mice Blood Lymphocytes Using Micronucleus Test

Pharmaceutical and Biomedical Research, 2020
Background: Despite its various clinical applications, cyclophosphamide (CP), an alkylating chemotherapeutic agent, has demonstrated numerous side effects, including genetic toxicity. Objectives: This study investigated the protective action of Origanum
Mohammad Shokrzadeh, Emran Habibi, Amir Shadboorestan, Aroona Chabra, Amirhossein Ahmadi   +4 more
doaj   +1 more source

Assessment of the genotoxicity of quinolone and fluoroquinolones contaminated soil with the Vicia faba micronucleus test [PDF]

, 2012
The genotoxicity of quinolone and fluroquinolones was assessed using the micronucleus (MN) test on Viciafaba roots by direct contact exposure to a solid matrix.
Bousquet-Mélou, Alain, Guiresse, Agnès Maritchù, Hafidi, Mohamed, Hamdi, Hassan, Khadra, Ahmed, Lacroix, Marlene Z., Merlina, Georges, Pinelli, Eric   +7 more
core   +3 more sources

Titanium Detected in Liver, Kidney, Spleen, and Intestine Is Not Related to Dose, Time, or Route of Exposure to Titanium Dioxide: A Systematic Review

Environmental Toxicology, EarlyView.
ABSTRACT Titanium dioxide (TiO2), used as a food additive (labeled E171 in Europe), was withdrawn from the European market in 2022. The E171 toxicity mechanism involves its uptake, oxidative stress, DNA damage, and inflammation. It has been hypothesized that the TiO2 accumulation nanoparticles (NPs) or E171 triggers tissue damage, and some studies have
Carmen Ximena Martínez‐Escutia, Estefany I. Medina‐Reyes, Eduardo Delgado‐Armenta, Yolanda I. Chirino   +3 more
wiley   +1 more source

Chromosomal radiosensitivity of human immunodeficiency virus positive/negative cervical cancer patients in South Africa [PDF]

, 2015
Cervical cancer is the second most common cancer amongst South African women and is the leading cause of cancer-associated mortality in this region. Several international studies on radiation-induced DNA damage in lymphocytes of cervical cancer patients ...
Baeyens, Ans, Francies, Flavia, Herd, Olivia, Kotzen, Jeffrey, Muller, Xanthene, Nxumalo, Zwide, Slabbert, Jacobus, Smith, Trudy, Vral, Anne   +8 more
core   +2 more sources

First Assessment of Genetic Damage in the Speckled Cockroach (Nauphoeta cinerea) After Consumption of Lettuce (Lactuca sativa) Cultivated and Commercialized in Northeastern, Brazil

Environmental Toxicology, EarlyView.
ABSTRACT This study reports, for the first time, the use of the speckled cockroach Nauphoeta cinerea as a promising bioindicator for genotoxic monitoring. It was validated through control groups (both positive and negative) in addition to testing lettuce (Lactuca sativa ) samples from public street markets consumed by N. cinerea specimens in Pernambuco,
Aleson Aparecido da Silva, Eduardo Henrique da Silva Melo, Érima Maria de Amorim, Maria Gislaine Pereira, Claudia Rohde   +4 more
wiley   +1 more source