Results 101 to 110 of about 870,242 (177)

Genome Aging in Women: Hematopoietic Loss of X Chromosome as An Exemplar

Aging Cell, Volume 25, Issue 11, November 2026.
As studies at the intersection of genetics and aging are rapidly advancing, genome aging provides a novel mechanism by which aging phenotypes occur. In this Review, the authors examine the rise, expansion, and the consequences of X chromosome loss in female blood cells.
Xihan Guo, Xueqin Dai
wiley   +1 more source

Role of Macronutrients and Micronutrients in DNA Damage: Results From a Food Frequency Questionnaire

Nutrition and Metabolic Insights, 2017
The links between diet and genomic instability have been under investigation for several decades, and evidence suggests a significant causal or preventive role for various dietary factors. This study investigates the influence of macronutrients (calories,
Carina Ladeira, Elisabete Carolino, Manuel C Gomes, Miguel Brito   +3 more
doaj   +1 more source

Mitochondrial Dysfunction as a Context‐Dependent Driver and Amplifier of the SASP: Targeting the mtDNA–cGAS–STING Axis for Next‐Generation Senotherapeutics

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Cellular senescence combines stable cell‐cycle arrest with mitochondrial and innate immune remodelling that shapes the senescence‐associated secretory phenotype (SASP). This narrative review evaluates mitochondrial dysfunction as a context‐dependent initiator or amplifier of senescence and examines mitochondrial DNA (mtDNA) sensing through ...
Hamza Kamaran Hama, Mohammed Ali Hama, Musa M. Zorab, Amirreza Gholami, Ammar Mohammed Al‐Farga   +4 more
wiley   +1 more source

Simple Fluorescent Micronucleus Assay-combination of Hg-banding Technique and In situ Hybridisation

, 2001
Recent development in cytogenetic and molecular techniques, particularly combination of cytochalasin B method and fluorescence In situ hybridisation (FISH) now allow sensitive identification of clastogenic versus aneugenic events.
Joksić, Gordana, Petrović-Novak, Angelina   +1 more
core   +4 more sources

Safety evaluation of the food enzyme glucan endo‐1,3‐β‐d‐glucosidase from the genetically modified Streptomyces violaceoruber strain pGlu

EFSA Journal, Volume 24, Issue 11, November 2026.
Abstract The food enzyme glucan endo‐1,3‐β‐d‐glucosidase (3‐β‐d‐glucan glucanohydrolase; EC 3.2.1.39) is produced with the genetically modified Streptomyces violaceoruber strain pGlu by Nagase (Europa) GmbH. The genetic modifications did not give rise to safety concerns.
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Cristina Andreoli, Andrea Terron, Andrey Yurkov, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Natália Kovalkovičová, Silvia Peluso, Yi Liu   +21 more
wiley   +1 more source

Evaluation of The Genotoxicity of Three Food Additives using CHO-K1 Cells under in vitro Micronucleus Flow Cytometry Assay

, 2017
Exposure of genotoxic substances come from various sources such as food additives. The aim of this study is to evaluate the genotoxicity of food additives in CHO-K1 cells by micronucleus test flow cytometry.
Herwandhani Putri, Ediati Sasmito, Dhania Novitasari, Beni Lestari, Edy Meiyanto, Sari Haryanti   +5 more
core   +1 more source

Micronucleus assay in rapid retrospective biological dosimetry [PDF]

, 2016
Rapid retrospective biological dosimetry allows absorbed dose evaluation post exposure to ionizing radiation. One of the main tools of biodosimetry is based on the analysis of the effects resulting from the impact of ionizing radiation on the cell ...
Miszczyk, J., Rawojć, K.
core  

2-Ethylhexyl Diphenyl Phosphate (EHDPP) Induces Hepatic Expression of Cytochrome P450s, Liver Damage, and Genotoxicity in Mice

Toxics
As a commonly present organophosphorus flame retardant and persistent organic pollutant, 2-ethylhexyl diphenyl phosphate (EHDPP) has been observed to be genotoxic in cultured human hepatoma (HepG2) cells which depends on CYP activities.
Zhao Zhou, Hongbin Gao, Shunda Zhu, Lvlue Cai, Yijing Chen, Keqi Hu, Yungang Liu   +6 more
doaj   +1 more source

Induction of micronuclei by zinc in human leukocytes: a study using cytokinesis-block micronucleus assay

, 2002
In the present study, we report the results of the capability of zinc chloride for the induction of micronuclei in cultured human leukocytes using cytokinesis-block micronucleus assay.
Talukder, Geeta, Santra, Madhumita, Das, Swapan Kumar, Sharma, Archana   +3 more
core   +1 more source

What are the Criteria and Conditions for Performing the Micronucleus Assay in Oral Exfoliated Cells from Waterpipe and Cigarette Smokers? [PDF]

Int J Prev Med, 2023
Ribeiro DA.
europepmc   +1 more source