Results 81 to 90 of about 16,085 (225)
BMC Oral Health, 2012 Background The Amazon represents an area of 61% of Brazilian territory and is undergoing major changes resulting from disorderly economic development, especially the advance of agribusiness.
Sisenando Herbert +4 more
doaj +1 more source
Micronucleus assay in genotoxicity assessment
Acta fytotechnica et zootechnica, 2016 Three different pesticide formulations were tested for micronuclei production and cell cycle arrest. Micronucleus test represents a suitable method for assessing chromosome damage because both chromosome breakage (clastogenicity) and chromosome loss (aneugenicity) can be measured simultaneously.
Viera Schwarzbacherova +3 more
openaire +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Ashwagandha, an adaptogen, is an important herb of Ayurveda used as a Rasayana for its various health benefits. This prospective, multi‐center, observational clinical study evaluates the safety (clinical and laboratory) of a standardized Ashwagandha Root Extract (ARE) on long‐term administration over 12 months. Male and female adults (N = 191)
Jaising Salve +6 more
wiley +1 more source
International Aquatic Research, 2018 The use of organophosphate pesticides (OPs) in agricultural practices in India has gained popularity due to their broad spectrum, low cost and high potency.
Avelyno H. D’Costa +3 more
doaj +1 more source
Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)
Phytotherapy Research, EarlyView.Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan +2 more
wiley +1 more source
The automated micronucleus assay for early assessment of genotoxicity in drug discovery
, 2013 International audienceRecent publications on the automated in vitro micronucleus assay show predictive values higher than 85% for the classification of in vitro aneugens, clastogens and non-genotoxic compounds.
Gerets, H.H.J. +6 more
core +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Titanium dioxide (TiO2), used as a food additive (labeled E171 in Europe), was withdrawn from the European market in 2022. The E171 toxicity mechanism involves its uptake, oxidative stress, DNA damage, and inflammation. It has been hypothesized that the TiO2 accumulation nanoparticles (NPs) or E171 triggers tissue damage, and some studies have
Carmen Ximena Martínez‐Escutia +3 more
wiley +1 more source
Effect of aqueous extract of Rosemary officinalis on cytotoxicity of CCL4 induced albino male mice
مجلة مركز بحوث التقنيات الاحيائية, 2018 This study focused the line on the effect of aqueous extract of Rosemary officinalis, as well as, effect of toxic compound CCL4, on micronucleus formation and mitotic index assay in albino male mice.
Ruqaya M. Ibrahim
doaj +1 more source
Environmental Toxicology, EarlyView.ABSTRACT This study reports, for the first time, the use of the speckled cockroach Nauphoeta cinerea as a promising bioindicator for genotoxic monitoring. It was validated through control groups (both positive and negative) in addition to testing lettuce (Lactuca sativa ) samples from public street markets consumed by N. cinerea specimens in Pernambuco,
Aleson Aparecido da Silva +4 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2016 Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX enzyme activity which affects the inflammatory response. Inflammation is associated with increasing cancer incidence. Pre-clinical and clinical studies have shown that NSAID treatment could cause
Diana Anderson +5 more
doaj +1 more source