Results 81 to 90 of about 870,242 (177)

Acute in vivo rat micronucleus assay

Report of the acute in vivo micronucleus assay for acetamide in ...
Michigan Biotechnology Institute, Jai Research Foundation   +1 more
core   +1 more source

Ferroportin deficiency drives olaparib resistance in ovarian cancer via the cGAS–STING–STAT3 survival axis

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Abstract Background Ovarian cancer (OC) remains the most lethal gynaecological malignancy, and acquired resistance to PARP inhibitors such as olaparib represents a major clinical challenge. Although dysregulation of iron metabolism has been implicated in tumorigenesis, the specific role of the iron exporter SLC40A1 (ferroportin, FPN) in mediating ...
Jiagui Song, Zhengyang Guo, Decao Yang, Ping Yu, Yinjia Li, Zhuhui Yuan, Xiaojuan Ma, Xianlong Li, Hongyan Guo, Lixiang Xue, Tong Liu   +10 more
wiley   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, Volume 46, Issue 11, Page 3973-3988, November 2026.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

The buccal micronucleus cytome assay: New horizons for its implementation in human studies

In this report we provide a summary of the presentations and discussion of the latest knowledge regarding the buccal micronucleus (MN) cytome assay. This information was presented at the HUMN workshop held in Malaga, Spain, in connection with the 2023 ...
Schunck, C., Volpi, E., Bonassi, S., Wultsch, G., Knasmueller, S., Nersesyan, A., Fenech, M., Bolognesi, C.   +7 more
core   +1 more source

Effect of aqueous extract of Rosemary officinalis on cytotoxicity of CCL4 induced albino male mice

مجلة مركز بحوث التقنيات الاحيائية, 2018
This study focused the line on the effect of aqueous extract of Rosemary officinalis, as well as, effect of toxic compound CCL4, on micronucleus formation and mitotic index assay in albino male mice.
Ruqaya M. Ibrahim
doaj   +1 more source

Bisphenol A Induces DNA Damage and Differential Cytotoxicity in Thyroid Cells: High‐Dose Effects Challenge Regulatory Thresholds

Journal of Applied Toxicology, Volume 46, Issue 11, Page 3882-3892, November 2026.
ABSTRACT Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been implicated in carcinogenesis; however, its effects on thyroid cells remain unclear. This study investigated BPA‐induced cytotoxicity and genotoxicity in thyroid cell lines, including normal follicular (Nthy‐ori 3‐1), papillary carcinoma (TPC‐1 and BCPAP) and anaplastic
Izabela Fernanda Dal' Bó, Natássia Elena Bufalo, Valdemar Máximo, Laura Sterian Ward   +3 more
wiley   +1 more source

Cytokinesis-blocked micronucleus assay results showing Mean and Standard Error values for Nuclear Division Index (NDI), Frequency of Micronucleus Binucleated Cells (FMNB), Frequency of Micronuclei (FMN), Nucleoplasmic Bridges (NB) and Nuclear Buds from each treatment with materials and controls.

, 2019
Cytokinesis-blocked micronucleus assay results showing Mean and Standard Error values for Nuclear Division Index (NDI), Frequency of Micronucleus Binucleated Cells (FMNB), Frequency of Micronuclei (FMN), Nucleoplasmic Bridges (NB) and Nuclear Buds from ...
Letícia de Aquino Penteado (7274147), Sidney José de Lima Ribeiro (7274153), Maurício Cavicchioli (7274141), Sybele Saska Specian (7274144), Fernanda Coelho (7274138), Raquel Mantuaneli Scarel-Caminaga (3691807), Ticiana Sidorenko de Oliveira Capote (7274156), Alexandra Ivo de Medeiros (7274150)   +7 more
core   +1 more source

Evaluation of genotoxic effect of different smoking habits by detecting micronucleus frequency in university students, A case control study

Zanco Journal of Medical Sciences
Background and objective: Cigarettes, shisha, and e-cigarettes are significant etiologic factors of oral cancers. Buccal mucosa is the first tissue that faces the pollutants and might reflect unhealthy processes in the body.
Reshna Kamal Albarzanji
doaj   +1 more source

DNA damage in healthy individuals and respiratory patients after treating whole blood in vitro with the bulk and nano forms of NSAIDs

Frontiers in Molecular Biosciences, 2016
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX enzyme activity which affects the inflammatory response. Inflammation is associated with increasing cancer incidence. Pre-clinical and clinical studies have shown that NSAID treatment could cause
Diana Anderson, Mojgan Najafzadeh, Charmaine Normington, Badie Jacob, Mohammad Isreb, Rajendran Gopalan   +5 more
doaj   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, Volume 46, Issue 11, Page 4076-4084, November 2026.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source