Results 71 to 80 of about 870,242 (177)

New Considerations on Meiosis, Affinity and Genomic Constitution in Aneuploids and Interploid Hybrids of Urochloa P. Beauv. (Brachiaria)

Plant Breeding, EarlyView.
ABSTRACT The combination of polyploidy, apomixis and the formation of aneuploid and interploid hybrids makes the genus Urochloa an interesting system for investigating meiotic stability and genome behaviour in grasses. In this study, routine meiotic analysis and genomic in situ hybridization (GISH) were used to (i) evaluate meiosis in three hybrids of ...
Isabella Campos Moraes, Pedro Henrique Mendes Carvalho, Fausto Souza Sobrinho, Vânia Helena Techio   +3 more
wiley   +1 more source

Application of chimeric mice with human hepatocytes for the evaluation of metabolically activated genotoxic substances

Genes and Environment
Background The in vivo micronucleus (MN) assay is used for evaluation of chromosomal aberration induced by chemicals, and the liver MN assay can detect genotoxic compounds which require metabolic activation to induce micronucleus formation.
Mayu Fujikawa, Ryoko Matsuyama, Chihiro Yamasaki, Chise Tateno, Hiroyuki Asano   +4 more
doaj   +1 more source

Lead-induced DNA damage in Vicia faba root cells: Potential involvement of oxidative stress [PDF]

, 2011
Genotoxic effects of lead (0–20 µM) were investigated in whole-plant roots of Vicia faba L., grown hydroponically under controlled conditions. Lead-induced DNA damage in V.
Jean, Séverine, Eric Pinelli, Silvestre, Jérôme, Séverine Jean, Pinelli, Eric, Pourrut, Bertrand, Bertrand Pourrut, Jérôme Silvestre   +7 more
core   +1 more source

Micronucleus frequency in children exposed to biomass burning in the Brazilian Legal Amazon region: a control case study

BMC Oral Health, 2012
Background The Amazon represents an area of 61% of Brazilian territory and is undergoing major changes resulting from disorderly economic development, especially the advance of agribusiness.
Sisenando Herbert, de Medeiros Silvia, Artaxo Paulo, Saldiva Paulo HN, de Souza Hacon Sandra   +4 more
doaj   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, Volume 46, Issue 12, Page 4396-4408, December 2026.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Acute in vivo mouse micronucleus assay

Report of the acute in vivo micronucleus assay for acetamide in ...
Michigan Biotechnology Institute, Jai Research Foundation   +1 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, Volume 20, Issue 11, Page 2820-2838, November 2026.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The micronucleus assay in radiation accidents [PDF]

, 2009
The cytokinesis-block micronucleus assay in peripheral blood lymphocytes is a standardised and validated technique for biodosimetry. Automated scoring of micronuclei allows large scale applications as in population triage in case of radiation accidents ...
Vral, Anne, Thierens, Hubert
core  

Induction of DNA damage in the peripheral blood of zebrafish (Danio rerio) by an agricultural organophosphate pesticide, monocrotophos

International Aquatic Research, 2018
The use of organophosphate pesticides (OPs) in agricultural practices in India has gained popularity due to their broad spectrum, low cost and high potency.
Avelyno H. D’Costa, S. K. Shyama, M. K. Praveen Kumar, Trisha M. Fernandes   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, Volume 20, Issue 11, Page 2839-2859, November 2026.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source