Results 11 to 20 of about 13,726,259 (365)

Suitability of the In Vitro Cytokinesis-Block Micronucleus Test for Genotoxicity Assessment of TiO₂ Nanoparticles on SH-SY5Y Cells. [PDF]

Int J Mol Sci, 2021
Fernández-Bertólez N, Brandão F, Costa C, Pásaro E, Teixeira JP, Laffon B, Valdiglesias V.   +6 more
europepmc   +3 more sources

Estimating the carcinogenic potency of chemicals from the in vivo micronucleus test. [PDF]

Mutagenesis, 2016
Soeteman-Hernández LG, Johnson GE, Slob W.   +2 more
europepmc   +2 more sources

Evaluation of the repeated-dose liver and gastrointestinal tract micronucleus assays with 22 chemicals using young adult rats: Summary of the collaborative study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/The Japanese Environmental Mutagen Society (JEMS) – Mammalian Mutagenicity Study Group (MMS)

Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 2015
Shuichi Hamada, Wakako Ohyama, Rie Takashima, Keisuke Shimada, Kazumi Matsumoto, Satoru Kawakami, Fuyumi Uno, Hajime Sui, Yasushi Shimada, Tadashi Imamura, Shoji Matsumura, Hisakazu Sanada, Kenji Inoue, Shigeharu Muto, Izumi Ogawa, Aya Hayashi, Tomomi Takayanagi, Yosuke Ogiwara, Akihisa Maeda, Emiko Okada, Yukari Terashima, Hironao Takasawa, Kazunori Narumi, Yumi Wako, Kazufumi Kawasako, Masaki Sano, Nobuyuki Ohashi, Takeshi Morita, Hajime Kojima, Masamitsu Honma, Makoto Hayashi   +30 more
openalex   +2 more sources

Micronucleus test for determining genotoxic damage

Turkish Bulletin of Hygiene and Experimental Biology, 2011
Micronuclei (MN) are formed during mitosis and do not integrate in the main nucleus. They may arise from a whole lagging chromosome or an acentric chromosome fragment. An increase of MN frequency indicates genomic instability. The MN test is commonly used to determine the genotoxic effects of chemical and physical agents on somatic cells. It is applied
Vedat Sekeroglu, Zulal Atli Sekeroglu
openaire   +2 more sources

Genotoxicity of Di (2-ethyl hexyl) phthalate

Zhongguo shipin weisheng zazhi, 2022
ObjectiveTo assess the genotoxicity of Di（2-ethylhexyl） phthalate （DEHP）.MethodsA series of guideline-compliant assays were performed to evaluate mutagenicity， chromosomal or DNA damage of DEHP， including Ames test， in vitro mammalian chromosome ...
LI Juntao, LI Wenxue, ZHANG Yan, YANG Guangyu, ZHUANG Runxuan, ZHANG Xiaojun, YANG Hui, ZHANG Bo, ZHU Wei, YANG Ying   +9 more
doaj   +1 more source

In vitro micronucleus assay: Method for assessment of nanomaterials using cytochalasin B

Frontiers in Toxicology, 2023
The in vitro micronucleus (MNvit) assay is used to evaluate the aneugenic and clastogenic potential of a test material based upon its ability to induce micronuclei in the cells.
Christopher S. Farabaugh, Shareen Doak, Shambhu Roy, Rosalie Elespuru   +3 more
doaj   +1 more source

Cytogenetic effect of caffeine in the micronucleus test

RUDN Journal of Medicine, 2021
Relevance. The consumption of caffeine-containing food in the modern world must necessarily be safe for humans, including should not affect the hereditary material of the body.
N. A. Durnova, A. R. Klantsataya, M. N. Kurchatova, A. Yu. Karetnikova, A. S. Sheremetyeva   +4 more
doaj   +1 more source

Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays. [PDF]

PLoS ONE, 2017
The chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one), or 2HMC, displays antileishmanial, antimalarial, and antioxidant activities. The aim of this study was to investigate the cytotoxic, genotoxic, mutagenic, and protective effects of
Débora Cristina da Silva Lima, Camila Regina do Vale, Jefferson Hollanda Véras, Aline Bernardes, Caridad Noda Pérez, Lee Chen-Chen   +5 more
doaj   +1 more source

Acute Oral Toxicity and Genotoxicity Test and Evaluation of Cinnamomum camphora Seed Kernel Oil

Foods, 2023
Cinnamomum camphora seed kernel oil (CCSKO) is one of the important natural medium chain triglycerides (MCT) resources, with more than 95.00% of medium chain fatty acids found in the world, and has various physiological effects.
Pengbo Wang, Dongman Wan, Ting Peng, Yujing Yang, Xuefang Wen, Xianghui Yan, Jiaheng Xia, Qingwen Zhu, Ping Yu, Deming Gong, Zheling Zeng   +10 more
doaj   +1 more source

Acute toxicity and genotoxicity studies on new melatonergic antidepressant GW117

Heliyon, 2023
GW117, a novel derivate compound of agomelatine that acts as both a 5-HT2C receptor antagonist and a MT1/MT2 receptor agonist, likely underlines the potent antidepressant action with less hepatotoxicity than agomelatine.
Mei Gao, Hui Ma, Tianbin Liu, Chong Cao, Zhiyong Zheng, Liansheng Tang, Wei Gu, Daizhou Zhang, Haiji Sun   +8 more
doaj   +1 more source