Results 81 to 90 of about 13,726,259 (365)

Genotoxicity evaluation of sodium dehydroacetate

Zhongguo shipin weisheng zazhi, 2020
Objective To study the genotoxicity of sodium dehydroacetate (Na-DHA). Methods Five strains of Salmonella Typhimurium (TA97a, TA98, TA100, TA102 and TA1535) were used with the presence and absence of S9 in bacterial reverse mutation test.
Xue GENG, Xiaopeng ZHANG, Yongning LI, Qiannan ZHANG, Haibo LIU, Wenming CUI, Hui YANG, Zhou YU, Xudong JIA   +8 more
doaj   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

Analysis of chromosomal radiosensitivity of healthy BRCA2 mutation carriers and non-carriers in BRCA families with the G2 micronucleus assay [PDF]

, 2017
Breast cancer risk drastically increases in individuals with a heterozygous germline BRCA1 or BRCA2 mutation, while it is estimated to equal the population risk for relatives without the familial mutation (non-carriers).
Baert, Annelot, Claes, Kathleen, De Leeneer, Kim, De Nobele, Sylvia, Depuydt, Julie, Malfait, Fransiska, Perletti, Gianpaolo, Poppe, Bruce, Van Damme, Tim, Van Maerken, Tom, Vral, Anne   +10 more
core   +1 more source

Evaluation of the standard battery of in vitro genotoxicity tests to predict in vivo genotoxicity through mathematical modeling: A report from the 8th International Workshop on Genotoxicity Testing

Environmental and Molecular Mutagenesis, EarlyView.
Abstract In human health risk assessment of chemicals and pharmaceuticals, identification of genotoxicity hazard usually starts with a standard battery of in vitro genotoxicity tests, which is needed to cover all genotoxicity endpoints. The individual tests included in the battery are not designed to pick up all endpoints.
Mirjam Luijten, Jan van Benthem, Takeshi Morita, Raffaella Corvi, Patricia A. Escobar, Yurika Fujita, Jennifer Hemmerich, Naveed Honarvar, David Kirkland, Naoki Koyama, David P. Lovell, Miriam Mathea, Andrew Williams, Stephen Dertinger, Stefan Pfuhler, Jeroen L. A. Pennings   +15 more
wiley   +1 more source

Fluorescence in situ hybridisation study of micronuclei in C3A cells following exposure to ELF-magnetic fields [PDF]

, 2019
Human C3A cells were exposed to extremely low frequency (50 Hz) magnetic fields (ELF-MF's) up to 500 mu T. They were subjected to the micronucleus assay using a Fluorescence In Situ Hybridization (FISH) technique with an in-house pan-centromere probe. We
Antonissen, Roel, Baeyens, Ans, Maes, Annemarie, Verschaeve, Luc, Vral, Anne   +4 more
core   +1 more source

Review of: "Evaluation of the genotoxicity in fish erythrocytes to diagnose the water quality of two Amazonian estuaries using the micronucleus test and comet assay" [PDF]

, 2021
Serkan Yılmaz
openalex   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Assessment of the potential in vivo ecotoxicity of Double-Walled Carbon Nanotubes (DWNTs) in water, using the amphibian Ambystoma mexicanum [PDF]

, 2007
Because of their specific properties (mechanical, electrical, etc), carbon nanotubes (CNTs) are being assessed for inclusion in many manufactured products.
Borm PJA, Bottini M, Cheng J, Colomer JF, Cui D, Emmanuel Flahaut, Eric Pinelli, Fernandez M, Ferrier V, Flahaut E, Flahaut E, Florence Mouchet, Gauthier L, Gauthier L, Godet F, Jaylet A, Jaylet A, Jia G, Krauter PW, Lam C, Laury Gauthier, Malins DC, Manna SK, Monteiro-Rivière NA., Mouchet F, Muller J, Oberdörster E, Oberdörster E, Perine Landois, Salvador-Morales C, Smart SK, Smith CJ, Tamura K, Templeton RC, Vuillaume M, Wang H, Warheit DB, Zoll C   +37 more
core   +3 more sources

Antimutagenic effect of resveratrol

Czech Journal of Food Sciences, 2005
Evidence exists from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity.
Martina Langová, Zdeňka Polívková, Petr Šmerák, Jiřina Bártová, Ivo Bárta   +4 more
doaj   +1 more source

Genotoxicity evaluation of Guibi-Tang extract using an in vitro bacterial reverse mutation assay, chromosome aberration assay, and in vivo micronucleus test

BMC Complementary and Alternative Medicine, 2014
BackgroundGuibi-Tang is a traditional herbal prescription made from 12 different herbs that is used in the treatment of amnesia and poor memory.MethodsIn the present study, we evaluated the acute oral toxicity and genotoxic potential of Guibi-Tang water ...
Mee-Young Lee, C. Seo, Ji-Young Kim, Hyeun-kyoo Shin   +3 more
semanticscholar   +1 more source