Microphthalmia-Associated Transcription Factor [PDF]
The American Journal of Pathology, 2015 Benilde Jiménez Cuenca +2 more
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Frontiers in Oncology, 2018 Drug resistance constitutes a major challenge in designing melanoma therapies. Microenvironment-driven tumor heterogeneity and plasticity play a key role in this phenomenon. Melanoma is highly heterogeneous with diverse genomic alterations and expression
Farzana Ahmed +2 more
doaj +1 more source
Pre- and pro-biotics may improve mineral absorption and retention in the growing male rat : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Science in Nutritional Science at Massey University, Turitea, Palmerston North, New Zealand [PDF]
, 2005 Probiotics are bacteria, which reside in the large intestine and concur beneficial health effects on their host. Their abundance can be selectively-stimulated by prebiotics, such as fructo-oligosaccharide (FOS); prebiotics are oligosaccharides, which are
Fear, Alison Lindsay
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Principles Of Differentiation And Morphogenesis [PDF]
, 2016 Developmental biology is the science connecting genetics with anatomy, making sense out of both. The body builds itself from the instructions of the inherited DNA and the cytoplasmic system that interprets the DNA into genes and creates intracellular and
Gilbert, Scott F., Rice, R.
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Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases [PDF]
, 2008 We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions and ...
Gil-Mi Ryu +4 more
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Adaptive resistance to RAF inhibitors in melanoma. [PDF]
, 2014 The discovery of activating mutations in BRAF at high frequency in cutaneous melanoma opened the door to new treatment options, which have resulted in significantly better patient outcomes.
Abel +45 more
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Emerging roles of MITF as a crucial regulator of immunity
Experimental and Molecular MedicineMicrophthalmia-associated transcription factor (MITF), a basic helix-loop-helix leucine zipper transcription factor (bHLH-Zip), has been identified as a melanocyte-specific transcription factor and plays a critical role in melanocyte survival ...
Aram Lee, Jihyun Lim, Jong-Seok Lim
doaj +1 more source
A transcriptional network underlies susceptibility to kidney disease progression
EMBO Molecular Medicine, 2012 The molecular networks that control the progression of chronic kidney diseases (CKD) are poorly defined. We have recently shown that the susceptibility to development of renal lesions after nephron reduction is controlled by a locus on mouse chromosome 6
Denise Laouari +9 more
doaj +1 more source
The Suppression Effects of Fat Mass and Obesity Associated Gene on the Hair Follicle-Derived Neural Crest Stem Cells Differentiating into Melanocyte by N6-Methyladenosine Modifying Microphthalmia-Associated Transcription Factor. [PDF]
Int J Stem Cells, 2023 Shang Z, Feng H, Xia L.
europepmc +1 more source
ALDH1A3 loss of function causes bilateral anophthalmia/microphthalmia and hypoplasia of the optic nerve and optic chiasm [PDF]
, 2017 The major active retinoid, all-trans retinoic acid, has long been recognized as critical for the development of several organs, including the eye. Mutations in STRA6, the gene encoding the cellular receptor for vitamin A, in patients with Matthew-Wood ...
Abouzeid, Hana +12 more
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