Microphthalmia in Texel sheep is associated with a missense mutation in the paired-like homeodomain 3 (PITX3) gene. [PDF]
PLoS ONE, 2010 Microphthalmia in sheep is an autosomal recessive inherited congenital anomaly found within the Texel breed. It is characterized by extremely small or absent eyes and affected lambs are absolutely blind. For the first time, we use a genome-wide ovine SNP
Doreen Becker +7 more
doaj +1 more source
MicroRNA-137 Targets Microphthalmia-Associated Transcription Factor in Melanoma Cell Lines [PDF]
Cancer Research, 2008 Abstract Micropthalmia-associated transcription factor (MITF) is the master regulator of melanocyte development, survival, and function. Frequent alteration in the expression of MITF is detected in melanoma, but the mechanism(s) underlying the alteration in expression have not been completely determined.
Lynne T, Bemis +8 more
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Induction of Melanocyte-specific Microphthalmia-associated Transcription Factor by Wnt-3a [PDF]
Journal of Biological Chemistry, 2000 Microphthalmia-associated transcription factor (Mitf) plays a critical role in the development of neural crest-derived melanocytes. Here, we show that exogenously added Wnt-3a protein, an intercellular signaling molecule, up-regulates the expression of endogenous melanocyte-specific Mitf (Mitf-M) mRNA in cultured melanocytes.
K, Takeda +8 more
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Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma
Biomolecules, 2021 Microphthalmia-associated transcription factor (MITF) is the principal transcription factor regulating pivotal processes in melanoma cell development, growth, survival, proliferation, differentiation and invasion. In recent years, convincing evidence has
Carla Abrahamian, Christian Grimm
doaj +1 more source
Journal of International Medical Research, 2020 Renal cell carcinoma (RCC) associated with Xp11.2 translocation/transcription factor E3 ( TFE3 ) gene fusion is a rare and independent subtype of RCC included in the classification of MiT (microphthalmia-associated transcriptional factor) family ...
Yuxiong Wang +5 more
doaj +1 more source
Mechanism of Mitf inhibition and morphological differentiation effects of hirsein A on B16 melanoma cells revealed by DNA microarray [PDF]
, 2012 BackgroundWe have previously reported that hirsein A inhibits melanogenesis in B16 melanoma cells by downregulating the Mitf gene expression.ObjectiveIn this study, microarray was employed to determine the transcriptional response of B16 cells to hirsein
Han Junkyu +5 more
core +1 more source
Microphthalmia-associated transcription factors activate mTORC1 through RagD GTPase gene expression [PDF]
Translational Cancer Research, 2017 The mechanistic target of rapamycin complex 1 (mTORC1) is a major serine/threonine kinase that stimulates cellular anabolic processes including protein and lipid synthesis while suppressing catabolic processes such as autophagy in response to growth factors and amino acids (1).
Edith, Jones, Ken, Inoki
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Aquaculture Reports, 2022 Leopard coral grouper (Plectropomus leopardus) is an indispensable kind of fish in the coral reef ecosystems and marine aquaculture, and the body color of leopard coral grouper is exhibited in black, brown or red.
Hongtao Liu +9 more
doaj +1 more source
Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6. [PDF]
, 2015 Vitamin A has biological functions as diverse as sensing light for vision, regulating stem cell differentiation, maintaining epithelial integrity, promoting immune competency, regulating learning and memory, and acting as a key developmental morphogen ...
Kassai, Miki +4 more
core +2 more sources
Mitf-Mdel, a novel melanocyte/melanoma-specific isoform of microphthalmia-associated transcription factor-M, as a candidate biomarker for melanoma [PDF]
, 2010 Background: Melanoma incidence is on the rise and advanced melanoma carries an extremely poor prognosis. Treatment options, including chemotherapy and immunotherapy, are limited and offer low response rates and transient efficacy. Thus, identification of
Yixiang Wang +4 more
core +2 more sources