Modulation of Microphthalmia-associated Transcription Factor Gene Expression Alters Skin Pigmentation [PDF]
Journal of Investigative Dermatology, 2002 The microphthalmia-associated transcription factor is implicated in melanocyte development and in the regulation of melanogenesis. Microphthalmia-associated transcription factor is thought to bind to the M-box promoter elements of tyrosinase, tyrosinase-related protein-1 and dopachrome tautomerase/tyrosinase-related protein-2 and transactivate these ...
Lin, C.B. +7 more
openaire +2 more sources
The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells [PDF]
, 2015 BACKGROUND: Dendritic cells (DC) are the most potent antigen-presenting cells (APC) with the unique ability to activate naïve T cells and to initiate and maintain primary immune responses. Immunosuppressive and anti-inflammatory stimuli on DC such as the
Daniela Dörfel +7 more
core +1 more source
SOX5 is involved in balanced MITF regulation in human melanoma cells [PDF]
, 2016 Background: Melanoma is a cancer with rising incidence and new therapeutics are needed. For this, it is necessary to understand the molecular mechanisms of melanoma development and progression.
Ast, Volker +8 more
core +1 more source
Lentigo maligna - anatomic location as a potential risk factor for recurrences after non-surgical treatment [PDF]
, 2016 Background: A higher incidence of lentigo maligna (LM) recurrences on the nose was previously observed in our cohort after non-surgical treatment. Objectives: To determine histological parameters that might be related to the previously observed higher ...
Doorn, M.B.A. (Martijn) van +4 more
core +11 more sources
OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs
Nature Communications, 2017 Lineage master regulators induce differentiation and how the melanocyte master regulator Microphthalmia-associated transcription factor (MITF) is regulated is unclear.
Danna Sheinboim +12 more
doaj +1 more source
Acetylation reprograms MITF target selectivity and residence time
Nature Communications, 2023 The ability of transcription factors to discriminate between different classes of binding sites associated with specific biological functions underpins effective gene regulation in development and homeostasis.
Pakavarin Louphrasitthiphol +15 more
doaj +1 more source
Platelet-derived growth factor C and calpain-3 are modulators of human melanoma cell invasiveness. [PDF]
, 2013 The molecular mechanisms responsible for the elevated metastatic potential of malignant melanoma are still not fully understood. In order to shed light on the molecules involved in the acquisition by melanoma of a highly aggressive phenotype, we compared
Arcelli, D +7 more
core +2 more sources
Journal of Integrative Agriculture, 2020 The present study investigates the expression of microphthalmia-associated transcription factor (MITF) and its contribution to the melanin deposition in Liancheng white ducks.
Qing-wu XIN +8 more
doaj +1 more source
Upregulation of Mitf by Phenolic Compounds-Rich Cymbopogon schoenanthus Treatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal Melanocytes [PDF]
, 2017 Melanin provides inherent protection against skin cancer by absorbing broad-spectrum radiant energy of UV radiation. Cutaneous malignant melanoma incidence has recently been observed to increase and the frequency is closely associated with the skin color,
Isoda Hiroko +5 more
core +1 more source
Journal of Allergy and Clinical Immunology, 2017 Background Histamine is a critical mediator of IgE/mast cell–mediated anaphylaxis. Histamine is synthesized by decarboxylating the amino acid histidine, a reaction catalyzed by the histidine decarboxylase (Hdc) gene–encoded enzyme HDC.
Yapeng Li +12 more
semanticscholar +1 more source