MicroRNA-210 Controls Mitochondrial Metabolism and Protects Heart Function in Myocardial Infarction. [PDF]
Circulation, 2022 Background: Ischemic heart disease remains a leading cause of death worldwide. In this study, we test the hypothesis that microRNA-210 protects the heart from myocardial ischemia-reperfusion (IR) injury by controlling mitochondrial bioenergetics and reactive oxygen species (ROS) flux. Methods:
Song R, Dasgupta C, Mulder C, Zhang L.
europepmc +3 more sources
MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. [PDF]
PLoS ONE, 2010 Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor prognosis.In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial ...
Elena Favaro +16 more
doaj +1 more source
Validation of a multiplex reverse transcription and pre-amplification method using TaqMan(®) MicroRNA assays. [PDF]
, 2014 Since the discovery of microRNAs (miRNAs), different approaches have been developed to label, amplify and quantify miRNAs. The TaqMan(®) technology, provided by Applied Biosystems (ABIs), uses a stem-loop reverse transcription primer system to ...
Lamon,S, Le Carré,J, Léger,B
core +16 more sources
Neuroprotective Effects of MicroRNA-210 on Hypoxic-Ischemic Encephalopathy [PDF]
BioMed Research International, 2013 Objectives. To reveal the effect of microRNA-210 on cell apoptosis caused by HIE.Methods. Postnatal day 7 rats after HI injury were intraventricularly injected with microRNA-210 mimic, microRNA-210 inhibitor, or physiological saline. 72 h after the injection, rats were sacrificed and the left hemispheres were collected. The expression level of microRNA-
Qiu, Jie +5 more
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MicroRNA-210 and its theranostic potential
Expert Opinion on Therapeutic Targets, 2016 MicroRNAs (miRNAs) are a set of small single-stranded noncoding RNAs with diverse biological functions. As a prototypical hypoxamir, human microRNA-210 (hsa-miR-210) is one of the most widely studied miRNAs thus far. In addition to its involvement in sophisticated regulation of numerous biological processes, miR-210 has also been shown to be associated
Ye, D-Q +5 more
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Hypoxia-inducible MiR-210 is an independent prognostic factor and contributes to metastasis in colorectal cancer. [PDF]
PLoS ONE, 2014 MicroRNA-210 (miR-210), the master hypoxamir, plays pleiotropic roles in certain cancers; however, its role in the development of human colorectal cancer remains unclear.
Ailin Qu +13 more
doaj +1 more source
MicroRNA-210 Suppresses Junction Proteins and Disrupts Blood-Brain Barrier Integrity in Neonatal Rat Hypoxic-Ischemic Brain Injury. [PDF]
, 2017 Cerebral edema, primarily caused by disruption of the blood-brain barrier (BBB), is one of the serious complications associated with brain injury in neonatal hypoxic-ischemic encephalopathy (HIE).
Dasgupta, Chiranjib +4 more
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miR-210: More than a silent player in hypoxi [PDF]
, 2011 Multiple studies have consistently established that miR (microRNA)-210 induction is a feature of the hypoxic response in both normal and transformed cells.
Devlin, Cecilia +3 more
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Up-Regulation of Cell-Free MicroRNA-1 and MicroRNA-221-3p Levels in Patients with Myocardial Infarction Undergoing Coronary Angiography [PDF]
Advanced Pharmaceutical Bulletin, 2021 Purpose: Myocardial infarction (MI), known as a multifactorial disease, remains the predominant cause of mortality and sudden deaths annually. The current study aimed to measure the expression of microRNA-1 and microRNA-221-3p in MI patients. Methods: In
Fatemeh Mansouri +1 more
doaj +1 more source
Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]
, 2018 Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R +8 more
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