Results 51 to 60 of about 21,599 (235)
MicroRNA 210 as a Biomarker for Congestive Heart Failure
Biological and Pharmaceutical Bulletin, 2013 MicroRNAs (miRNAs) are endogenous small RNAs that are 18-23 nucleotides long. Recently, plasma miRNAs were reported to be sensitive and specific biomarkers of various pathological conditions. In the present study, we focused on miR-210, which is known to be induced by hypoxia and might therefore be an excellent biomarker for congestive heart failure ...
Kosuke, Endo +14 more
openaire +3 more sources
Acute hypoxia induces upregulation of microRNA-210 expression in glioblastoma spheroids [PDF]
CNS Oncology, 2015 Tumor hypoxia and presence of tumor stem cells are related to therapeutic resistance and tumorigenicity in glioblastomas. The aim of the present study was therefore to identify microRNAs deregulated in acute hypoxia and to identify possible associated changes in stem cell markers.Glioblastoma spheroid cultures were grown in either 2 or 21% oxygen ...
Rosenberg, Tine Agerbo +7 more
openaire +3 more sources
ROD1 is a seedless target gene of hypoxia-induced miR-210. [PDF]
PLoS ONE, 2012 Most metazoan microRNA (miRNA) target sites have perfect pairing to the "seed" sequence, a highly conserved region centering on miRNA nucleotides 2-7.
Pasquale Fasanaro +5 more
doaj +1 more source
Biomedicines, 2021 Apoptotic cell death of cardiomyocytes is a characteristic hallmark of ischemia–reperfusion (I/R) injury. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxic stress.
Gurdeep Marwarha +4 more
doaj +1 more source
Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension [PDF]
, 2015 Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR‐210‐ISCU1/2 axis cause Fe‐S deficiencies in vivo and promote PH.
Anderson, Daniel Griffith +3 more
core +1 more source
Function and mechanism of microRNA‑210 in acute cerebral infarction
Experimental and Therapeutic Medicine, 2017 Acute cerebral infarction (ACI) is a common cerebrovascular disease. Previous studies have indicated that microRNAs (miRs) are aberrantly expressed in patients with ACI. However, the functions of miRs in the pathogenesis of ACI still require further investigation.
Wang, Jun, Zhang, Yuezhan, Xu, Feng
openaire +3 more sources
Biomedical Papers, 2019 Objective: To explore whether miR-210 expression can be used as a diagnostic and prognostic marker in acute fetal hypoxia. Methods: Whole blood samples of 29 women and their fetuses without hypoxia and 24 women and their fetuses with hypoxia were ...
Barbara Vonkova +4 more
doaj +1 more source
Neuropsychiatric Disease and Treatment, 2022 Qin Zhou,1 Huanjun Luo,2 Xiaowei Wang,2 Peng Li,3 Haibo Kong,1 Baomei He1 1Center for Reproductive Medicine, Department of Pediatrics, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, People’s ...
Zhou Q +5 more
doaj
Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs. [PDF]
, 2020 Many crucial cardiovascular adaptations occur in the body during pregnancy to ensure successful gestation. Maladaptation of the cardiovascular system during pregnancy can lead to complications that promote cardiac dysfunction and may lead to heart ...
Aryan, Laila +3 more
core
Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery [PDF]
, 2016 Introduction Exosome nanoparticles carry a composite cargo, including microRNAs (miRs). Cultured cardiovascular cells release miR-containing exosomes. The exosomal trafficking of miRNAs from the heart is largely unexplored.
Angelini, GD +10 more
core +1 more source