Results 71 to 80 of about 21,599 (235)

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice

Journal of Nanobiotechnology, 2019
Background Accumulating evidence shows that microRNA-210 (miR-210) holds great promise to improve angiogenesis for brain tissue repair after cerebral ischemia.
Huixin Zhang, Jin Wu, Jiahuan Wu, Qi Fan, Jingchao Zhou, Junwen Wu, Sichen Liu, Jie Zang, Jinhai Ye, Ming Xiao, Tian Tian, Jun Gao   +11 more
doaj   +1 more source

Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells [PDF]

, 2020
microRNAs are short regulatory RNAs in metazoan cells. Regulation of miRNA activity and abundance is evident in human cells where availability of target messages can influence miRNA biogenesis by augmenting the Dicer1-dependent processing of precursors ...
Barman, Bahnisikha, Bhattacharyya, Suvendra N., Bose, Mainak, Chakrabarty, Yogaditya, Chatterjee, Susanta   +4 more
core  

SUPER: Upcycling Genetic Parts for Precise Gene Expression Control, Leakage Minimization, and Genetic Circuit Stability

Advanced Science, EarlyView.
To precisely modulate natural and synthetic regulatory parts, SUPER is introduced as a sophisticated and tunable controller of genetic devices without requiring sequence modification on the target. SUPER enhances dynamic range of RNA‐, chemical‐, temperature‐, and protein‐responsive biosensors up to 1011%, and converts biosensors to cover an expanded ...
Taeyang Heo, Dongwon Park, Woosub Shin, Jongmin Kim   +3 more
wiley   +1 more source

PLC-beta 1 regulates the expression of miR-210 during mithramycin-mediated erythroid differentiation in K562 cells [PDF]

, 2014
PLC-beta 1 (PLCβ1) inhibits in human K562 cells erythroid differentiation induced by mithramycin (MTH) by targeting miR-210 expression. Inhibition of miR-210 affects the erythroid differentiation pathway and it occurs to a greater extent in MTH-treated ...
Bavelloni, Alberto, Blalock, William, Cocco, Lucio, Faenza, Irene, Fiume, Roberta, Matteucci, Alessandro, McCubrey, James A., NC DOCKS at East Carolina University, Poli, Alessandro, Ramazzotti, Giulia   +9 more
core   +5 more sources

Relationship between hypoxia and downstream pathogenic pathways in preeclampsia

Hypertension in Pregnancy, 2017
Defects in angiogenesis and mitochondrial function in the placenta contribute to the pathogenesis of preeclampsia; however upstream regulators of these pathways are not known.
Henri Augusto Korkes, Leandro De Oliveira, Nelson Sass, Saira Salahuddin, S. Ananth Karumanchi, Augustine Rajakumar   +5 more
doaj   +1 more source

Prognostic evaluation of microRNA-210 in various carcinomas

Medicine, 2017
We performed this meta-analysis to provide a comprehensive evaluation of the role of MicroRNA-210 (miR-210) expression on the overall survival (OS) rate of cancers.We searched for relevant available literatures on miR-210 and cancer until November 1st, 2016 on the databases PubMed, EMBASE, Cochrane Library, and Science Direct database.
Liu, Yincheng, Wang, Yichun, Xu, Qitong, Zhou, Xiang, Qin, Zhiqiang, Chen, Chen, Zhang, Qijie, Tian, Ye, Zhang, Chao, Li, Xiao, Qin, Chao   +10 more
openaire   +2 more sources

MicroRNA-210 regulates placental adaptation to maternal hypoxic stress during pregnancy†

Biology of Reproduction, 2020
AbstractMicroRNA (miR)-210 is a well-known hypoxia-inducible small RNA. Increasing in vitro evidence demonstrates its involvement in regulating multiple behaviors of placental trophoblasts. However, direct in vivo evidence remains lacking. In the present study, we generated a miR-210-deficient mouse strain using CRISPR/Cas9 technology, in which miR-210
Xiaotao, Bian, Juan, Liu, Qian, Yang, Yanlei, Liu, Wentong, Jia, Xiaodong, Zhang, Yu-Xia, Li, Xuan, Shao, Yan-Ling, Wang   +8 more
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma [PDF]

, 2016
Cancer metastasis is a multistep process that involves a series of tumor-stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors.
Chan, LK, Kai, AKL, Lee, MF, Lo, CLR, Ng, IOL, Wong, CCL, Wong, CM   +6 more
core   +1 more source