microRNA-630 Regulates Underglycosylated IgA1 Production in the Tonsils by Targeting TLR4 in IgA Nephropathy [PDF]
Frontiers in Immunology, 2020 IgA nephropathy (IgAN) is the most common primary glomerular disease. The characteristic pathology involves immune complexes formed by the deposition of IgA1 and underglycosylated IgA1 aggregates in the mesangial area, which may be accompanied by the ...
Li-Yu He, You-Ming Peng, Liu Chan
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Increased MicroRNA-630 Expression in Gastric Cancer Is Associated with Poor Overall Survival [PDF]
PLoS ONE, 2014 MicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression. Among various microRNAs, MiR-630 has recently been identified to be implicated in many critical processes in human malignancies. We aimed to investigate the
Dake Chu, Zhengwei Zhao, Yunming Li
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Circular RNA MTO1 intercorrelates with microRNA‐630, both associate with Enneking stage and/or pathological fracture as well as prognosis in osteosarcoma patients [PDF]
Journal of Clinical Laboratory Analysis, 2021 AbstractObjectiveCircular RNA‐mitochondrial tRNA translation optimization 1 (circ‐MTO1) not only involves in bioprocess of various cancers, but also regulates osteosarcoma progression by regulating microRNA‐630 (miR‐630). However, the clinical role of circ‐MTO1 and miR‐630 in osteosarcoma is still obscure.
Ye Wen, Senbing Zhang
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Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression [PDF]
Oncogene, 2016 MicroRNAs (miRNAs) are small RNA molecules that affect cellular processes by controlling gene expression. Recent studies have shown that hypoxia downregulates Drosha and Dicer, key enzymes in miRNA biogenesis, causing a decreased pool of miRNAs in cancer and resulting in increased tumor growth and metastasis.
Rajesha Rupaimoole +2 more
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A low microRNA-630 expression confers resistance to tyrosine kinase inhibitors in EGFR-mutated lung adenocarcinomas via miR-630/YAP1/ERK feedback loop [PDF]
Theranostics, 2018 Purpose: MicroRNA-630 plays dual roles in apoptosis and drug resistance in human cancers. However, the role of miR-630 in resistance to tyrosine kinase inhibitors (TKIs) in lung adenocarcinoma remains to be elucidated. Methods: Manipulation of miR-630 and its targeted gene YAP1 and/or combination of inhibitor treatments was performed to explore whether
De-Wei Wu, Yao-Chen Wang, Lee Wang
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Biochemical and Biophysical Research Communications, 2018 MicroRNA-630 (miR-630) has been implicated in the development and progression of multiple cancers. The current study aimed to investigate the role of miR-630 in chemoresistant epithelial ovarian cancer. MiR-630 expression levels were detected in ovarian cancer cell line SKOV3 and paclitaxel-resistant SKOV3 (SKOV3-TR) via microarray and qRT-PCR. MiR-630
Kyung Jin Eoh +2 more
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MicroRNA 630 Represses NANOG Expression through Transcriptional and Post-Transcriptional Regulation in Human Embryonal Carcinoma Cells. [PDF]
Int J Mol Sci, 2021 The pluripotent transcription factor NANOG is essential for maintaining embryonic stem cells and driving tumorigenesis. We previously showed that PKC activity is involved in the regulation of NANOG expression. To explore the possible involvement of microRNAs in regulating the expression of key pluripotency factors, we performed a genome-wide analysis ...
Chu WK, Hung LM, Hou CW, Chen JK.
europepmc +5 more sources
MicroRNA-630: A promising avenue for alleviating inflammation in diabetic kidney disease. [PDF]
World J DiabetesDiabetic kidney disease (DKD) is one of the complications of diabetes, affecting millions of people worldwide. The relentless progression of this condition can lead to kidney failure, requiring life-altering interventions such as dialysis or transplants. Accumulating evidence suggests that immunologic and inflammatory elements play an important role in
Donate-Correa J +3 more
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MicroRNA-630: A potential guardian against inflammation in diabetic kidney disease. [PDF]
World J DiabetesIn this editorial, we comment on the article by Wu et al published “MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4”. Diabetic kidney disease (DKD) stands as a significant complication occurring from diabetes mellitus, which contributes substantially to the morbidity and mortality ...
Al Madhoun A.
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MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4. [PDF]
World J DiabetesBACKGROUND Diabetic kidney disease (DKD) is a major complication of diabetes mellitus. Renal tubular epithelial cell (TEC) damage, which is strongly associated with the inflammatory response and mesenchymal trans-differentiation, plays a significant role in DKD; However, the precise molecular mechanism is unknown.
Wu QS +5 more
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