Results 11 to 20 of about 3,995 (136)
miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer [PDF]
Molecular Cancer, 2014 Background While the treatment of HER2 over-expressing breast cancer with recent HER-targeted drugs has been highly effective for some patients, primary (also known as innate) or acquired resistance limits the success of these drugs.
Claire Corcoran, Sweta Rani, John Crown
exaly +6 more sources
Biochemical and Biophysical Research Communications, 2018 MicroRNA-630 (miR-630) has been implicated in the development and progression of multiple cancers. The current study aimed to investigate the role of miR-630 in chemoresistant epithelial ovarian cancer. MiR-630 expression levels were detected in ovarian cancer cell line SKOV3 and paclitaxel-resistant SKOV3 (SKOV3-TR) via microarray and qRT-PCR. MiR-630
Kyung Jin Eoh +2 more
exaly +6 more sources
MicroRNA-630 is a prognostic marker for patients with colorectal cancer
Tumor Biology, 2014 MicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression. Among various microRNAs, miR-630 has recently been identified to be implicated in many critical processes in human malignancies. We investigated the expression pattern and prognostic value of miR-630 in human colorectal cancer by utilizing cancer and ...
Dake Chu, Jianyong Zheng, Yunming Li
exaly +5 more sources
MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4. [PDF]
World J DiabetesBACKGROUND Diabetic kidney disease (DKD) is a major complication of diabetes mellitus. Renal tubular epithelial cell (TEC) damage, which is strongly associated with the inflammatory response and mesenchymal trans-differentiation, plays a significant role in DKD; However, the precise molecular mechanism is unknown.
Wu QS +5 more
europepmc +3 more sources
miR-630 as a therapeutic target in pancreatic cancer stem cells: modulation of the PRKCI-Hedgehog signaling axis [PDF]
Biology DirectBackground MicroRNAs (miRNAs) are critical regulators of cancer progression, prompting our investigation into the specific function of miR-630 in pancreatic cancer stem cells (PCSCs).
Jun Zou +5 more
doaj +2 more sources
miR-378a-5p and miR-630 induce lens epithelial cell apoptosis in cataract via suppression of E2F3 [PDF]
Brazilian Journal of Medical and Biological Research, 2020 Cataract, an eye disease that threatens the health of millions of people, brings about severe economic burden for patients and society. MicroRNA (miR)-378a-5p and miR-630 were recognized as essential regulators in multiple cancers.
Weiwei Gao, Xiaoqing Zhou, Ruihua Lin
doaj +1 more source
Journal of Immunology Research, 2022 Purpose. Hypoxia has crucial functions in the development and metastasis of cervical cancer by inducing the expression of numerous genes, including microRNA genes.
Qiaohui Gao +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Ovarian cancer (OC) is a lethal gynecological malignancy. Extracellular vesicles (EVs) are crucial media in cell-to-cell communication by carrying microRNAs (miRs).
Yulan Cui, Deying Wang, Min Xie
doaj +1 more source
MicroRNA expression profiles of whole blood in lung adenocarcinoma. [PDF]
PLoS ONE, 2012 The association of lung cancer with changes in microRNAs in plasma shown in multiple studies suggests a utility for circulating microRNA biomarkers in non-invasive detection of the disease.
Santosh K Patnaik +5 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Inflammation in epicardial adipose tissue (EAT) may contribute to coronary atherosclerosis. Myocardial bridge is a congenital anomaly in which the left anterior descending coronary artery takes a “tunneled” course under a bridge of myocardium:
Tracey McLaughlin +10 more
doaj +1 more source