Results 21 to 30 of about 108,740 (146)

MicroRNA-630 suppresses tumor metastasis through the TGF-β- miR-630-Slug signaling pathway and correlates inversely with poor prognosis in hepatocellular carcinoma. [PDF]

Oncotarget, 2016
The epithelial-mesenchymal transition (EMT) is the key process that drives tumor metastasis. Accumulating evidence suggests that the deregulation of some microRNAs (miRNAs), is implicated in this process. Here, we highlight the function and molecular mechanism of miR-630 and its potential clinical application in hepatocellular carcinoma (HCC).
Chen WX, Zhang ZG, Ding ZY, Liang HF, Song J, Tan XL, Wu JJ, Li GZ, Zeng Z, Zhang BX, Chen XP.   +10 more
europepmc   +4 more sources

MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4. [PDF]

World J Diabetes
BACKGROUND Diabetic kidney disease (DKD) is a major complication of diabetes mellitus. Renal tubular epithelial cell (TEC) damage, which is strongly associated with the inflammatory response and mesenchymal trans-differentiation, plays a significant role in DKD; However, the precise molecular mechanism is unknown.
Wu QS, Zheng DN, Ji C, Qian H, Jin J, He Q.   +5 more
europepmc   +3 more sources

MicroRNA-630 is a prognostic marker for patients with colorectal cancer

Tumor Biology, 2014
MicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression. Among various microRNAs, miR-630 has recently been identified to be implicated in many critical processes in human malignancies. We investigated the expression pattern and prognostic value of miR-630 in human colorectal cancer by utilizing cancer and ...
Yunming Li, Jianyong Zheng, Qingchuan Zhao   +2 more
exaly   +3 more sources

miR-630 as a therapeutic target in pancreatic cancer stem cells: modulation of the PRKCI-Hedgehog signaling axis [PDF]

Biology Direct
Background MicroRNAs (miRNAs) are critical regulators of cancer progression, prompting our investigation into the specific function of miR-630 in pancreatic cancer stem cells (PCSCs).
Jun Zou, Sha Yang, Chongwu He, Lei Deng, Bangran Xu, Shuai Chen   +5 more
doaj   +2 more sources

Maternal Obesity and MicroRNAs in Breast Milk: Implications for Infant Developmental Programming. [PDF]

Obes Rev
ABSTRACT This review explores the relationship between maternal obesity and alterations in the expression of microRNAs (miRNAs) in breast milk, highlighting how these changes may influence the developmental programming of the infant. Evidence suggests that maternal obesity can affect the bioactive composition of breast milk, including miRNA profiles ...
Santos GM, de Souza FIS, Pisani LP.
europepmc   +2 more sources

miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer

Molecular Cancer, 2014
Background While the treatment of HER2 over-expressing breast cancer with recent HER-targeted drugs has been highly effective for some patients, primary (also known as innate) or acquired resistance limits the success of these drugs.
John Crown, Lorraine O'Driscoll, Sweta Rani   +2 more
exaly   +2 more sources

microRNA-630 promotes cell proliferation and inhibits apoptosis in the HCT116 human colorectal cancer cell line

Molecular Medicine Reports, 2017
Dysregulation of microRNAs (miRNAs) in colorectal cancer provides important opportunities for the development of future miRNA‑based therapies. The present study aimed to assess the role of miRNA‑630 (miR‑630) expression in colorectal cancer. HCT116 human colorectal cancer cells were transfected with miR‑630 inhibitor, mimic or control miRNA, and the ...
Lijuan, Zhang, Gang, Feng, Xinyan, Zhang, Yawen, Ding, Xiaojuan, Wang   +4 more
exaly   +4 more sources

miR-378a-5p and miR-630 induce lens epithelial cell apoptosis in cataract via suppression of E2F3 [PDF]

Brazilian Journal of Medical and Biological Research, 2020
Cataract, an eye disease that threatens the health of millions of people, brings about severe economic burden for patients and society. MicroRNA (miR)-378a-5p and miR-630 were recognized as essential regulators in multiple cancers.
Weiwei Gao, Xiaoqing Zhou, Ruihua Lin
doaj   +1 more source

HIF-3α-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop

Journal of Immunology Research, 2022
Purpose. Hypoxia has crucial functions in the development and metastasis of cervical cancer by inducing the expression of numerous genes, including microRNA genes.
Qiaohui Gao, Zhenghua Ren, Shengyuan Jiao, Juan Guo, Xia Miao, Jin Wang, Junye Liu   +6 more
doaj   +1 more source

RETRACTED: Tumor-Derived Extracellular Vesicles Promote Activation of Carcinoma-Associated Fibroblasts and Facilitate Invasion and Metastasis of Ovarian Cancer by Carrying miR-630

Frontiers in Cell and Developmental Biology, 2021
Ovarian cancer (OC) is a lethal gynecological malignancy. Extracellular vesicles (EVs) are crucial media in cell-to-cell communication by carrying microRNAs (miRs).
Yulan Cui, Deying Wang, Min Xie
doaj   +1 more source