Results 21 to 30 of about 135,345 (146)

MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4. [PDF]

World J Diabetes
BACKGROUND Diabetic kidney disease (DKD) is a major complication of diabetes mellitus. Renal tubular epithelial cell (TEC) damage, which is strongly associated with the inflammatory response and mesenchymal trans-differentiation, plays a significant role in DKD; However, the precise molecular mechanism is unknown.
Wu QS, Zheng DN, Ji C, Qian H, Jin J, He Q.   +5 more
europepmc   +3 more sources

miR-630 as a therapeutic target in pancreatic cancer stem cells: modulation of the PRKCI-Hedgehog signaling axis [PDF]

Biology Direct
Background MicroRNAs (miRNAs) are critical regulators of cancer progression, prompting our investigation into the specific function of miR-630 in pancreatic cancer stem cells (PCSCs).
Jun Zou, Sha Yang, Chongwu He, Lei Deng, Bangran Xu, Shuai Chen   +5 more
doaj   +2 more sources

MMpred: functional miRNA – mRNA interaction analyses by miRNA expression prediction [PDF]

, 2012
Background: MicroRNA (miRNA) directed gene repression is an important mechanism of posttranscriptional regulation. Comprehensive analyses of how microRNA influence biological processes requires paired miRNA-mRNA expression datasets.
Wilson, Paul, Cauchi, Michael, Stempor, Przemyslaw A.   +2 more
core   +8 more sources

miR-378a-5p and miR-630 induce lens epithelial cell apoptosis in cataract via suppression of E2F3 [PDF]

Brazilian Journal of Medical and Biological Research, 2020
Cataract, an eye disease that threatens the health of millions of people, brings about severe economic burden for patients and society. MicroRNA (miR)-378a-5p and miR-630 were recognized as essential regulators in multiple cancers.
Weiwei Gao, Xiaoqing Zhou, Ruihua Lin
doaj   +1 more source

Epididymosome-Supplemented Extender Induces Changes in Morpho-Functional Traits and microRNA Levels of Post-Thaw Sperm and Improves Embryo Developmental Potential. [PDF]

Mol Reprod Dev
ABSTRACT While molecular signature contributes to sperm quality and fertility potential, sperm may lost key molecules during cryopreservation. Since sperm cells are transcriptionally inert and rely on interactions with epididymosomes (epEVs) to acquire molecules, herein, we investigated the effects of the addition of epEVs to the cryopreservation ...
Haupenthal LG, de Almeida MA, Prado CM, Silva AN, Schneider GM, Rosa PMDS, Meirelles FV, da Silveira JC, Perecin F, Alves MBR.   +9 more
europepmc   +2 more sources

HIF-3α-Induced miR-630 Expression Promotes Cancer Hallmarks in Cervical Cancer Cells by Forming a Positive Feedback Loop

Journal of Immunology Research, 2022
Purpose. Hypoxia has crucial functions in the development and metastasis of cervical cancer by inducing the expression of numerous genes, including microRNA genes.
Qiaohui Gao, Zhenghua Ren, Shengyuan Jiao, Juan Guo, Xia Miao, Jin Wang, Junye Liu   +6 more
doaj   +1 more source

RETRACTED: Tumor-Derived Extracellular Vesicles Promote Activation of Carcinoma-Associated Fibroblasts and Facilitate Invasion and Metastasis of Ovarian Cancer by Carrying miR-630

Frontiers in Cell and Developmental Biology, 2021
Ovarian cancer (OC) is a lethal gynecological malignancy. Extracellular vesicles (EVs) are crucial media in cell-to-cell communication by carrying microRNAs (miRs).
Yulan Cui, Deying Wang, Min Xie
doaj   +1 more source

Maternal Obesity and MicroRNAs in Breast Milk: Implications for Infant Developmental Programming. [PDF]

Obes Rev
ABSTRACT This review explores the relationship between maternal obesity and alterations in the expression of microRNAs (miRNAs) in breast milk, highlighting how these changes may influence the developmental programming of the infant. Evidence suggests that maternal obesity can affect the bioactive composition of breast milk, including miRNA profiles ...
Santos GM, de Souza FIS, Pisani LP.
europepmc   +2 more sources

MicroRNA expression profiles of whole blood in lung adenocarcinoma. [PDF]

PLoS ONE, 2012
The association of lung cancer with changes in microRNAs in plasma shown in multiple studies suggests a utility for circulating microRNA biomarkers in non-invasive detection of the disease.
Santosh K Patnaik, Sai Yendamuri, Eric Kannisto, John C Kucharczuk, Sunil Singhal, Anil Vachani   +5 more
doaj   +1 more source

Relationship Between Coronary Atheroma, Epicardial Adipose Tissue Inflammation, and Adipocyte Differentiation Across the Human Myocardial Bridge

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Inflammation in epicardial adipose tissue (EAT) may contribute to coronary atherosclerosis. Myocardial bridge is a congenital anomaly in which the left anterior descending coronary artery takes a “tunneled” course under a bridge of myocardium:
Tracey McLaughlin, Ingela Schnittger, Anna Nagy, Elizabeth Zanley, Yue Xu, Yanqiu Song, Koen Nieman, Jennifer A. Tremmel, Damini Dey, Jack Boyd, Harold Sacks   +10 more
doaj   +1 more source