Results 151 to 160 of about 31,660 (233)

Correction for Fan et al., Arabidopsis AAR2, a conserved splicing factor in eukaryotes, acts in microRNA biogenesis. [PDF]

Proc Natl Acad Sci U S A, 2022
europepmc   +1 more source

Network Model to Predict Age‐Related Transcriptional Reprogramming

Aging Cell, Volume 25, Issue 9, September 2026.
This study presents a network‐based model to predict intracellular responses to shifts in the extracellular environment and demonstrates the utility of the framework by estimating chondrocyte responses to age‐associated extracellular changes. Extracellular ligands are mapped to corresponding receptors, which serve as seed nodes for signal propagation ...
Tyler J. McNeill, Fabrisia Ambrosio, Hirotaka Iijima   +2 more
wiley   +1 more source

Spatiotemporal 22q11.21 Protein Network Implicates DGCR8-Dependent MicroRNA Biogenesis as a Risk for Late-Fetal Cortical Development in Psychiatric Diseases. [PDF]

Life (Basel), 2021
Chen L, Cai W, Wang W, Liu Z, Lin GN.
europepmc   +1 more source

MicroRNA‐Driven Regulation of β‐Cell Function in Type 2 Diabetes: Molecular Mechanisms, Network Insights, and Translational Perspectives

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT MicroRNAs (miRNAs) have emerged as central regulators of pancreatic islet biology, influencing β‐cell development, proliferation, and function. In type 2 diabetes (T2D), both adaptive and maladaptive miRNA responses shape β‐cell compensation and progressive secretory dysfunction.
Lena Eliasson, Alexandros Karagiannopoulos, Mototsugu Nagao, Anna Wendt   +3 more
wiley   +1 more source

MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1. [PDF]

Nucleic Acids Res
Downie Ruiz Velasco A, Parsons AL, Heatley MC, Martin ARG, Smart AD, Shah N, Jopling CL.   +6 more
europepmc   +1 more source

Autophagy in MASLD: A Metabolic and Precision Medicine Perspective

Liver International, Volume 46, Issue 9, September 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common chronic liver condition worldwide and a major contributor to cirrhosis and hepatocellular carcinoma (HCC). While metabolic triggers such as obesity and insulin resistance are key drivers of MASLD, growing evidence has identified defects in intracellular quality
Alessandra Cazzaniga, Silvia Frigo, Alessandro Cherubini, Eniada Rrapaj, Luca Valenti   +4 more
wiley   +1 more source

Identification of <i>Cr</i>DCL1-mediated microRNA biogenesis in green alga <i>Chlamydomonas reinhardtii</i>. [PDF]

Front Microbiol
Sun T, Tao M, Di Q, Hu Z, Li H, Lou S.
europepmc   +1 more source

Complexity in regulating microRNA biogenesis in cancer. [PDF]

Exp Biol Med (Maywood), 2020
Chen PS, Lin SC, Tsai SJ.
europepmc   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

tRNA, yRNA, and rRNA fragment excisions do not involve canonical microRNA biogenesis machinery. [PDF]

MicroPubl Biol
Godang NL, Nguyen AD, DeMeis JD, Paudel SS, Campbell NJ, Barnes KJ, Jeon K, Roussell AS, Gregson KA, Borchert GM.   +9 more
europepmc   +1 more source