Results 151 to 160 of about 50,169 (235)

Multiomic characterization of small cell lung cancer: Real‐world insights into therapeutic opportunities

Cancer, Volume 132, Issue 5, 1 March 2026.
NK, natural killer; STING, Stimulator of Interferon Genes; TCI, T‐cell inflamed. Abstract Background The dominant expression of lineage‐related transcription factors (TFs)—ASCL1, NEUROD1, POU2F3, and, controversially, YAP1—has enabled the classification of small cell lung cancer (SCLC) into distinct subtypes (SCLC‐A/N/P/Y, respectively).
Sonam Puri, Andrew Elliott, Abdul Rafeh Naqash, Hassan Abu Shukair, Kathleen C. Kerrigan, Shiven Patel, Andreas Seeber, Florian Kocher, Dipesh Uprety, Hirva Mamdani, Amit A. Kulkarni, Gilberto Lopes, Balazs Halmos, Hossein Borghaei, Wallace Akerley, Gabriel L. Sica, Stephen V. Liu, Trudy G. Oliver, Taofeek K. Owonikoko   +18 more
wiley   +1 more source

Recurrent microsatellite instability-high thymic carcinoma showing complete response to immune checkpoint inhibitor: A case report. [PDF]

Oncol Lett
Nakagawa T, Aruga N, Watanabe H, Masuda R, Yamada S, Iwazaki M.   +5 more
europepmc   +1 more source

The Aberrant Activation of NLRP3 in Microsatellites Stability Colon Cancer Promotes M2 Macrophage Polarization Based on the TCGA Database and Tissue Microarray Analysis

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Microsatellites stability (MSS) colon cancer patients exhibit a significant suppressive immune status, and the functional status of tumor NLRP3 immunosomes plays an important role in regulating the tumor immune microenvironment, but whether they are involved in the regulation of immunosuppression in MSS patients is unclear ...
Li Lu, Menglin Wu, Xunzhen Jiang, Tong Liu, Weihua Fu, Weidong Li, Xue Li, Zhicheng Zhao   +7 more
wiley   +1 more source

Tumor characteristics impact prognosis in deficient mismatch repair/microsatellite instability-high localized colorectal cancer-a systematic review and meta-analysis. [PDF]

JNCI Cancer Spectr
Saqi IK, Nielsen AT, Madsen MT, Gögenur I, Orhan A, Justesen TF.   +5 more
europepmc   +1 more source

Transposable elements: Functional aspects and applications as drivers of crop innovation

Crop Science, Volume 66, Issue 2, March/April 2026.
Abstract Transposable elements (TEs), which were once relegated to the status of genomic parasites, are today accepted as important agents of plant genome evolution and adaptation. This review integrates evidence pointing to their dual function as drivers of genetic diversity and instability, with a focus on their contribution to phenotypic innovation,
Flávia Layse Belém Medeiros, José Ribamar Costa Ferreira‐Neto, Jarbson Henrique Oliveira Silva, Cinthia Carla Claudino Grangeiro Nunes, Ana Luíza Trajano Mangueira de Melo, Ayug Bezerra Lemos, Madson Allan de Luna‐Aragão, Agnes Angélica Guedes de Barros, Simon Orozco‐Arias, Eliseu Binneck, Francismar Correa Marcelino‐Guimarães, Ana Cristina Brasileiro‐Vidal, Ana Maria Benko‐Iseppon   +12 more
wiley   +1 more source

Identifying actionable genetic mutations and microsatellite instability in liquid biopsy of colorectal cancer. [PDF]

J Genet Eng Biotechnol
Kassem NM, Seadawy MG, Gaafar M, Kassem HA, Ahmed Hussein AF, Ali Rizk EM, Hassan MA, AbdelAziz RH, Abdelradi MM, El-Hosseny MF, Abdulla M, Moneim RA.   +11 more
europepmc   +1 more source

TRAF7‐Mutated Fibromyxoid Spindle Cell Tumor of Bone: An Osseous Case Expanding the Spectrum of TRAF7‐Mutated Tumors With Over 20 Years Clinical Follow‐Up

Genes, Chromosomes and Cancer, Volume 65, Issue 3, March 2026.
ABSTRACT TRAF7 mutations are a rare occurrence in human cancer and have recently been described in a group of mesenchymal tumors with varying clinical course. Herein, we expand the spectrum of TRAF7‐mutated fibromyxoid spindle cell tumors by reporting the first case to arise in bone.
Laura M. Warmke, Ani Toklu, Spencer M. Richardson, Christopher D. Collier, L. Daniel Wurtz, Lauren M. Ladd, Roman Shrestha, Devin J. Conway   +7 more
wiley   +1 more source

Microsatellite Instability Status and Mismatch Repair Defects Testing in Endometrial Cancer-Insights from the Multicenter E-PEC Trial. [PDF]

Diagnostics (Basel)
Eser B, Papior D, Salmanton-García J, Cornely OA, Morgenstern B, Herpel C, Radosa JC, Almuheimid A, Aktas B, Weydandt L, Wittenborn J, Meyer-Wilmes P, Friebe V, Leidinger C, Kimmig R, Thangarajah F.   +15 more
europepmc   +1 more source

Successful Preservation of the Penis After en Bloc Resection of Locally Recurrent Rectal Cancer Involving the Left Crus of the Corpus Cavernosum and Corpus Spongiosum

IJU Case Reports, Volume 9, Issue 2, March 2026.
ABSTRACT Introduction We report a case of locally recurrent rectal cancer involving the penile base successfully treated with penis‐preserving salvage surgery. Case Presentation A 63‐year‐old man underwent abdominoperineal resection for locally advanced rectal cancer, followed by three metastasectomies for inguinal lymph node recurrences and a ...
Tomonori Kanagawa, Masaya Ito, Misato Takao, Masahiro Toide, Shuichiro Kobayashi, Daisuke Nakano, Kazushige Kawai, Fumitaka Koga   +7 more
wiley   +1 more source

Microsatellite instability and its impact on nutritional and inflammatory profiles in colorectal cancer. [PDF]

World J Gastrointest Surg
Qu HD, Gao X, Xiao P, Jiao Y.
europepmc   +1 more source