Results 51 to 60 of about 31,010 (266)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Adaptive hierarchical filtering particle swarm optimization for multiple magnetic dipoles modeling of space equipment

Scientific Reports
Accurate modeling of multiple magnetic dipoles is essential for characterizing spacecraft-generated magnetic fields and mitigating their interference with sensitive onboard instruments.
Ye Liu, Xingjian Shi, Shengfeng Meng, Wenzhe Yang, Ziruo Fang, Zhiming Cai, Huawang Li   +6 more
doaj   +1 more source

Research on Task Satellite Selection Method for Space Object Detection LEO Constellation Based on Observation Window Projection Analysis

Aerospace, 2021
Aiming at the task planning and scheduling problem of space object detection LEO constellation (SODLC) for detecting space objects in deep space background, a method of SODLC task satellite selection based on observation window projection analysis is ...
Shengyu Zhang, Zhencai Zhu, Haiying Hu, Yuqing Li   +3 more
doaj   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

SpaceLight: A Framework for Enhanced On-Orbit Navigation Imagery

Aerospace
In the domain of space rendezvous and docking, visual navigation plays a crucial role. However, practical applications frequently encounter issues with poor image quality.
Zhang Zhang, Jiaqi Feng, Liang Chang, Lei Deng, Dong Li, Chaoming Si   +5 more
doaj   +1 more source

Dynamic Regulation of Endogenous Transcription Factor Hubs at Single‐Molecule Resolution

Advanced Science, EarlyView.
This study combines single‐molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms neomorphic hubs that dynamically assemble and dissolve. The hubs are regulated during mitosis, by RNA, and by specific chemicals.
Shawn Yoshida, Yanghao Zhong, Akiko Kumagai, William G. Dunphy, Shasha Chong   +4 more
wiley   +1 more source

Breaking the Diffraction Barrier: A Hybrid Framework Combining Physical Modulation and Neural Diffusion for Subdiffraction Target Recovery

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Although most aircraft are equipped with active communication systems, such as ADS-B and satellite links, these systems may fail in emergencies or when signals are lost. At this point, remote sensing, as a passive observation method that does not require
Xuening Liu, Zengshan Yin, Chongbin Guo, Changhao Wu   +3 more
doaj   +1 more source

Early‐Phase Research in Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Optimization of Test Mass Motion State for Enhancing Stiffness Identification Performance in Space Gravitational Wave Detection

Aerospace
In space gravitational wave detection, various physical effects in the spacecraft, such as self-gravity, electricity, and magnetism, will introduce undesirable parasitic stiffness.
Ningbiao Tang, Ziruo Fang, Zhongguang Yang, Zhiming Cai, Haiying Hu, Huawang Li   +5 more
doaj   +1 more source