Results 61 to 70 of about 86,640 (310)

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Breaking the Diffraction Barrier: A Hybrid Framework Combining Physical Modulation and Neural Diffusion for Subdiffraction Target Recovery

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Although most aircraft are equipped with active communication systems, such as ADS-B and satellite links, these systems may fail in emergencies or when signals are lost. At this point, remote sensing, as a passive observation method that does not require
Xuening Liu, Zengshan Yin, Chongbin Guo, Changhao Wu   +3 more
doaj   +1 more source

Standardization and application of microsatellite markers for variety identification in tomato and wheat [PDF]

, 2001
The present study is part of a EU project that aims to demonstrate the technical viability of STMS markers for variety identification. As examples two important European crop species, tomato and wheat were chosen. Initially, about 30-40 STMS markers were
Bredemeijer, G., Cooke, R., Ganal, M., Isaac, P., Peeters, R., Vosman, B.   +5 more
core   +2 more sources

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Optimization of Test Mass Motion State for Enhancing Stiffness Identification Performance in Space Gravitational Wave Detection

Aerospace
In space gravitational wave detection, various physical effects in the spacecraft, such as self-gravity, electricity, and magnetism, will introduce undesirable parasitic stiffness.
Ningbiao Tang, Ziruo Fang, Zhongguang Yang, Zhiming Cai, Haiying Hu, Huawang Li   +5 more
doaj   +1 more source

Inferencia del origen del bovino Criollo Cubano a través del análisis de patri- y matrilinajes [PDF]

, 2011
Antes de descubrimiento, no existían bovinos en América. Los primeros, fueron introducidos en la Antillas Mayores (La Española, Puerto Rico, Jamaica y Cuba), y desde allí trasladados al resto de Latinoamérica.
Acosta, A., Garcia, J., Giovambattista, Guillermo, Liron, Juan Pedro, Peral Garcia, Pilar, Posik, Diego Manuel, Rogberg Muñoz, Andres, Uffo, O.   +7 more
core   +2 more sources

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Determination of population structure and stock composition of chum salmon (Oncorhynchus keta) in Russia determined with microsatellites [PDF]

, 2008
Variation at 14 microsatellite loci was examined in 34 chum salmon (Oncorhynchus keta) populations from Russia and evaluated for its use in the determination of population structure and stock composition in simulated mixed-stock fishery samples.
Beacham, Terry D., Le, Khai D., Varnavskaya, Nataly V., Wetklo, Michael H.   +3 more
core  

Experimental harvesting of fish populations drives genetically based shifts in body size and maturation [PDF]

, 2013
Size-selective harvesting in commercial fisheries can induce rapid changes in biological traits. While experimental and wild harvested populations often exhibit clear shifts in body size and maturation associated with fishing pressure, the relative ...
Christine Dreyer, Cock van Oosterhout, Fernanda M Rodrigues, Gary R Carvalho, Indar W Ramnarine, Martin I Taylor, Salinas S, Serinde J van Wijk, Simon Creer, Stokes K   +9 more
core   +1 more source