Results 51 to 60 of about 98,869 (304)

Human UDP-Glucuronosyltransferase 2B4 and 2B7 Are Responsible for Naftopidil Glucuronidation in Vitro

Frontiers in Pharmacology, 2018
Naftopidil (NAF) is widely used for the treatment of benign prostatic hyperplasia and prevention of prostate cancer in elderly men. These patients receive a combination of drugs, which involves high risk for drug–drug interaction.
Xia-Wen Liu, Yi Rong, Xing-Fei Zhang, Jun-Jun Huang, Yi Cai, Bi-Yun Huang, Liu Zhu, Bo Wu, Ning Hou, Cheng-Feng Luo   +9 more
doaj   +1 more source

Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS

Pharmaceutical Biology, 2021
Context Ambrisentan is an oral endothelin-receptor antagonist (ERA). However, there is no report on the interaction between ambrisentan and shikonin.
Tian Lan, Ping Fang, Xuemei Ye, Xia Lan, Ren-ai Xu   +4 more
doaj   +1 more source

In vivo effect of dried chicory root (Cichorium intybus L.) on xenobiotica metabolising cytochrome P450 enzymes in porcine liver [PDF]

, 2011
Cytochrome P450 (CYP) enzymes are widely studied for their involvement in metabolism of drugs and endogenous compounds. In porcine liver, CYP1A2,2Aand 2E1 are important for the metabolism of skatole.Feeding chicory roots to pigs is known to decrease the ...
Ekstrand, Bo, Rasmussen, Martin Krøyer, Zamaratskaia, Galia   +2 more
core   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Nanostructures of diamond, graphene oxide and graphite inhibit CYP1A2, CYP2D6 and CYP3A4 enzymes and downregulate their genes in liver cells

International Journal of Nanomedicine, 2018
Barbara Strojny,1 Ewa Sawosz,1 Marta Grodzik,1 Sławomir Jaworski,1 Jarosław Szczepaniak,1 Malwina Sosnowska,1 Mateusz Wierzbicki,1 Marta Kutwin,1 Sylwia Orlińska,1 André Chwalibog2 1Division of Nanobiotechnology, Warsaw University of Life ...
Strojny B, Sawosz E, Grodzik M, Jaworski S, Szczepaniak J, Sosnowska M, Wierzbicki M, Kutwin M, Orlińska S, Chwalibog A   +9 more
doaj  

Enzymatic synthesis of cytidine diphosphate diglyceride

Journal of Lipid Research, 1966
Evidence is presented for the enzymatic formation of cytidine diphosphate diglyceride in microsomal preparations from guinea pig liver according to the reaction:CTP + phosphatidic acid ⇌ CDP-diglyceride + P—O—P.Conditions have been found in which the ...
James R. Carter, Eugene P. Kennedy
doaj   +1 more source

In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease. [PDF]

, 2018
BackgroundLiver disease (LD) prolongs mirtazapine half-life in humans, but it is unknown if this occurs in cats with LD and healthy cats.Hypothesis/objectivesTo determine pharmacokinetics of administered orally mirtazapine in vivo and in vitro (liver ...
Benson, Kellyi K, Fitzpatrick, Rikki L, Gustafson, Daniel L, Quimby, Jessica M, Ramirez, Dominique, Sieberg, Liberty G, Wittenburg, Luke A   +6 more
core  

Transport of Cytoplasmically Synthesized Proteins into the Mitochondria in a Cell Free System from Neurospora crassa [PDF]

, 1977
Synthesis and transport of mitochondrial proteins were followed in a cell-free homogenate of Neurospora crassa in which mitochondrial translation was inhibited. Proteins synthesized on cytoplasmic ribosomes are transferred into the mitochondrial fraction.
Andrews T. M., Bingham R. W., Blair G. E., Davidian N. M., Dobberstein B., Dolken G., Gaitskhoki V. S., Godinot C., Gonzalez-Cadavid N. F., Gonzalez-Cadavid N. F., Grollmann A. P., Hallermayer G., Kadenbach B., Kadenbach B., Kadenbach B., Kellems R. E., Kellems R. E., Kellems R. E., Kellems R. E., Marra E., Milstein C., Morris A., O'Brien R. L., Pfaff E., Redman C. M., Shore G. C., Takanami M., Tata J. R., Weiss H., Wojtczak L., Wojtczak L.   +30 more
core   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease

Journal of Lipid Research, 2009
The effects of dietary monosodium glutamate (MSG) on trans-fatty acid (TFA)-induced nonalcoholic fatty liver disease (NAFLD) are addressed in an animal model.
Kate S. Collison, Zakia Maqbool, Soad M. Saleh, Angela Inglis, Nadine J. Makhoul, Razan Bakheet, Mohammed Al-Johi, Rana Al-Rabiah, Marya Z. Zaidi, Futwan A. Al-Mohanna   +9 more
doaj   +1 more source