Results 51 to 60 of about 129,619 (377)
Molecular Informatics, Volume 41, Issue 12, December 2022., 2022 Abstract A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active enzyme trimer system (Model A), namely that bound to three glutathione (GSH) cofactor ...
Simone Di Micco +2 more
wiley +1 more source
Comparison of Cholesterol Lowering Diets: Apple, Casein Cytochrom P450 protein and Cholesterol 7α Hydroxylase Activities in Hamsters [PDF]
, 2010 Lithogenic diet, casein and apple fiber diets were fed to hamsters for 3-5 weeks. For control group, animals were fed on normal Purina chow without any supplement.
Rakesh Sharma, Rakesh K. Tandon
core +2 more sources
Animal Models and Experimental Medicine, EarlyView.ApoA4‐Cre rats and Cyp2c11‐Cre rats were produced using CRISPR/Cas9 tool. The Cre rats were crossed with Rosa26‐imCherry rats to obtain the Apoa4‐Cre/Rosa26‐imCherry and Cyp2c11‐Cre/Rosa26‐imCherry rats, which showed the specific expression of Cre recombinases in the liver.
Wei Dong +6 more
wiley +1 more source
Molecular Nutrition &Food Research, Volume 66, Issue 24, December 2022., 2022 Duodenal mucosa in early‐stage type 2 diabetes mellitus (ED), late‐stage type 2 diabetes mellitus injected with streptozotocin‐nicotinamide (STZ/NAD) (LD) and treated‐silicon LD (LD‐Si) groups. Silicon partially reversed LD group alterations: decreased absorptive area and acyl‐Coenzyme A:cholesterol acyltransferase 2 (ACAT2) levels, and increased ...
Marina Hernández‐Martín +9 more
wiley +1 more source
Sac1p mediates the adenosine triphosphate transport into yeast endoplasmic reticulum that is required for protein translocation. [PDF]
, 1995 Protein translocation into the yeast endoplasmic reticulum requires the transport of ATP into the lumen of this organelle. Microsomal ATP transport activity was reconstituted into proteoliposomes to characterize and identify the transporter protein.
Bankaitis, VA, Mayinger, P, Meyer, DI
core
PROTEOMICS, Volume 22, Issue 23-24, December 2022., 2022 Abstract The X‐linked inherited neuromuscular disorder Duchenne muscular dystrophy is characterised by primary abnormalities in the membrane cytoskeletal component dystrophin. The almost complete absence of the Dp427‐M isoform of dystrophin in skeletal muscles renders contractile fibres more susceptible to progressive degeneration and a leaky ...
Paul Dowling +3 more
wiley +1 more source
PROTEOMICS, Volume 23, Issue 1, January 2023., 2023 Abstract It is challenging to study regulatory genetic variants as gene expression is affected by both genetic polymorphisms and non‐genetic regulators. The mRNA allele‐specific expression (ASE) assay has been increasingly used for the study of cis‐acting regulatory variants because cis‐acting variants affect gene expression in an allele‐specific ...
Lucy Her +6 more
wiley +1 more source
Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS
Pharmaceutical Biology, 2021 Context Ambrisentan is an oral endothelin-receptor antagonist (ERA). However, there is no report on the interaction between ambrisentan and shikonin.
Tian Lan +4 more
doaj +1 more source
Life, 2023 Oxidative stress is one of the key factors responsible for many diseases–neurodegenerative (Parkinson and Alzheimer) diseases, diabetes, atherosclerosis, etc.
Ivanka Kostadinova +4 more
doaj +1 more source
Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-Ultraviolet A (PUVA) sensitivity [PDF]
, 2013 Background: There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochemotherapy, used to treat skin diseases including psoriasis.
Deeni, Yusuf Y. +4 more
core +3 more sources