Results 61 to 70 of about 97,218 (302)

Synthesis and turnover of cerebroside sulfate of myelin in adult and developing rat brain

Journal of Lipid Research, 1974
The turnover of cerebroside sulfate (sulfatide) was followed in both microsomal and myelin fractions of developing and adult rat brains after an intracerebral injection of Na235SO4.
Firoze B. Jungalwala
doaj   +1 more source

Qualification of Human Liver Microsomes for Antibacterial Activity Screening of Drug Metabolites

Applied Microbiology, 2023
Microsomes are commonly used to perform in vitro drug metabolism, predominantly to form phase I drug metabolites. Pooled microsomes from multiple donors can contain microorganisms from underlying microbial diseases.
Navid Jubaer
doaj   +1 more source

Smooth microsomes. a trap for cholesteryl ester formed in hepatic microsomes.

Journal of Biological Chemistry, 1980
Acyl-CoA:cholesterol acyltransferase was found predominantly (85%) in RNA-rich microsomes, the rest being in RNA-poor and smooth microsomes. However, the esterified cholesterol concentration of smooth microsomes was 2-fold greater than that of RNA-rich microsomes, suggesting the possibility of an interaction between RNA-rich and smooth microsomes.
S Hashimoto, A M Fogelman
openaire   +3 more sources

Toxic Evaluations of Calea phyllolepis Extracts Standardized on 6‐epi‐β‐Verbesinol Coumarate and Its In Silico Prediction of the Toxicity

Chemistry &Biodiversity, EarlyView.
In vivo and in silico toxicological effects of Calea phyllolepis extracts Standardized on 6‐epi‐β‐Verbesinol Coumarate. ABSTRACT Medicinal plants are traditionally used in folk medicine. Still, there is a misconception about the safety/efficacy of natural treatments, which results in few studies on the toxic, genotoxic, and mutagenic potential of ...
Suele Bierhals Vencato, Guilherme Borsoi, Cleverson Feistel, Mariele Feiffer Charão, Angélica Rocha Joaquim, Jaqueline Nascimento Picada, Alexandre de Barros Falcão Ferraz   +6 more
wiley   +1 more source

Electrochemical Probing of Human Liver Subcellular S9 Fractions for Drug Metabolite Synthesis

Metabolites
Human liver subcellular fractions, including liver microsomes (HLM), liver cytosol fractions, and S9 fractions, are extensively utilized in in vitro assays to predict liver metabolism.
Daphne Medina, Bhavana Omanakuttan, Ricky Nguyen, Eman Alwarsh, Charuksha Walgama   +4 more
doaj   +1 more source

The yeast P5 type ATPase, Spf1, regulates manganese transport into the endoplasmic reticulum [PDF]

, 2013
The endoplasmic reticulum (ER) is a large, multifunctional and essential organelle. Despite intense research, the function of more than a third of ER proteins remains unknown even in the well-studied model organism Saccharomyces cerevisiae.
A Chesi, A Samali, A Szkopińska, AB Bowman, AD Gitler, AH Futerman, Alaa Abdul-Sada, Anthony H. Futerman, AR Reddi, C Janke, C Onyewu, C Suzuki, C Suzuki, CB Brachmann, CC Paulusma, CD Davis, D Berchtold, D Lockshon, D Mandal, D Sorger, DJ Tipper, DK Breslow, E Losev, E Papanikou, E Sammels, E Wiederhold, EH Hettema, F Sherman, Fischl, Frances M. Platt, G Giaever, GA Castillon, GA Castillon, Giuseppe Condomitti, GK Voeltz, GR Corradi, H Yoshida, Howard Riezman, I Braakman, Isabelle Riezman, J Ko, J Meldolesi, J Shima, JA Sullivan, JK Pittman, JM De Freitas, K Araki, K Krumpe, KB Axelsen, LJ Wuestehube, LS Weingarten, LT Jensen, M Fujita, M Fujita, M Fujita, M North, M Schuldiner, M Schuldiner, Maya Schuldiner, MC Jonikas, MS Bae-Lee, Márton Megyeri, N Rimon, Nitzan Rimon, NP Mira, Oscar C. W. Chen, P Estrada de Martin, P Fagone, PJ Schultheis, PL Pedersen, RC Dickson, RC Dickson, RD Gietz, S Ichikawa, S Vashist, S-X Tan, SA Heidler, SC Dos Santos, SL Hansen, SR Cronin, SR Cronin, Stephen W. Michnick, TP Levine, U Loizides-Mangold, Ursula Loizides-Mangold, V Cerantola, V V Kushnirov, VC Culotta, W Kühlbrandt, X Tang, X Zhou, XF Liu, XL Guan, Y Chen, YD Lobsanov, Yifat Cohen   +95 more
core   +4 more sources

Development of Keap1‐Nrf2 Protein–Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene‐2‐acetamide Scaffold, and its Anti‐Inflammatory Effects

ChemMedChem, EarlyView.
Pyrrolidine‐type naphthalene‐2‐acetamide compound 5i inhibits Kelch‐like ECH‐associated protein 1 (Keap1)‐nuclear factor erythroid 2‐related factor 2 (Nrf2) protein–protein interaction by binding to the Keap1‐DC domain; it subsequently activates intracellular Nrf2 and induces Nrf2‐target genes.
Daisuke Yasuda, Kai Toyoshima, Koujin Kojima, Hanako Ishida, Kazuma Kaitoh, Riyo Imamura, Kayoko Kanamitsu, Hirotatsu Kojima, Megumi Funakoshi‐Tago, Masanori Osawa, Tomoyuki Ohe, Tomoya Hirano   +11 more
wiley   +1 more source

Phospholipids and acyl groups of subcellular membrane fractions from human intracranial tumors

Journal of Lipid Research, 1974
The phospholipids from subcellular fractions of human intracranial tumors were examined. For comparison, microsomes were isolated from a fetal human brain and from the gray matter of adult human brains.
G.Y. Sun, B.S. Leung
doaj   +1 more source

In vivo effect of dried chicory root (Cichorium intybus L.) on xenobiotica metabolising cytochrome P450 enzymes in porcine liver [PDF]

, 2011
Cytochrome P450 (CYP) enzymes are widely studied for their involvement in metabolism of drugs and endogenous compounds. In porcine liver, CYP1A2,2Aand 2E1 are important for the metabolism of skatole.Feeding chicory roots to pigs is known to decrease the ...
Ekstrand, Bo, Rasmussen, Martin Krøyer, Zamaratskaia, Galia   +2 more
core   +1 more source

Potent Antisickling Furaldehyde Analogs for Acute Sickle Cell Therapy: Enhanced Efficacy and Intravenous Formulation Potential

ChemMedChem, EarlyView.
This study reports novel 5‐HMF analogs with potent antisickling activities. Lead compound MMA509 enhances hemoglobin oxygen affinity and prevents erythrocyte sickling. Crystal structure of hemoglobin‐MMA509 complex explains MMA509 mechanism of action. An IV formulation is successfully developed, positioning MMA509 as a promising fast‐acting treatment ...
Abdelsattar M. Omar, Moustafa E. El‐Araby, Tarek A. Ahmed, Akua K. Donkor, Albert Opare, Mohini S. Ghatge, Anfal S. Aljahdali, Rana T. Alhashimi, Trevohn N. Robinson, Benita Balogun, Mariana Macias, Salma Roland, Yan Zhang, Faik N. Musayev, Osheiza Abdulmalik, Martin K. Safo   +15 more
wiley   +1 more source