Results 61 to 70 of about 129,619 (377)

Liver microsomes; an integrated morphological and biochemical study.

, 1956
Rat liver, liver homogenates, and microsome fractions separated therefrom were examined systematically in the electron microscope in sections of OsO 4 -fixed, methacrylate-embedded tissue and pellets. It was found that most microsomes are morphologically
G. Palade, P. Siekevitz
semanticscholar   +1 more source

Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life

CPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 1, Page 110-121, January 2023., 2023
Abstract Indomethacin is used commonly in preterm neonates for the prevention of intracranial hemorrhage and closure of an abnormally open cardiac vessel. Due to biomedical advances, the infants who receive this drug in the neonatal intensive care unit setting have become younger, smaller, and less mature (more preterm) at the time of treatment.
Wojciech Krzyzanski, Bradley Stockard, Andrea Gaedigk, Allison Scott, Whitney Nolte, Kim Gibson, J. Steven Leeder, Tamorah Lewis   +7 more
wiley   +1 more source

Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker. [PDF]

, 2013
Profenofos is a direct acting phosphorothioate organophosphorus (OP) pesticide capable of inhibiting β-esterases such as acetylcholinesterase, butyrylcholinesterase, and carboxylesterase.
Chi, Lai-Har, Dadson, Oswald A, Ellison, Corie A, Farahat, Fayssal M, Farahat, Taghreed, Lein, Pamela J, McGarrigle, Barbara P, Olson, James R, Singleton, Steven T   +8 more
core   +1 more source

Evaluating the performance of machine‐learning regression models for pharmacokinetic drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 1, Page 122-134, January 2023., 2023
Abstract Combination therapy or concomitant drug administration can be associated with pharmacokinetic drug–drug interactions, increasing the risk of adverse drug events and reduced drug efficacy. Thus far, machine‐learning models have been developed that can classify drug–drug interactions.
Jaidip Gill, Marie Moullet, Anton Martinsson, Filip Miljković, Beth Williamson, Rosalinda H. Arends, Venkatesh Pilla Reddy   +6 more
wiley   +1 more source

Phospholipids and acyl groups in subcellular fractions from human cerebral cortex

Journal of Lipid Research, 1973
Subcellular fractionation of human brain cortex obtained at autopsy yielded microsomal and synaptosome-rich fractions from the gray matter and microsomal and purified myelin fractions from the white matter.
Grace Y. Sun
doaj  

Qualification of Human Liver Microsomes for Antibacterial Activity Screening of Drug Metabolites

Applied Microbiology, 2023
Microsomes are commonly used to perform in vitro drug metabolism, predominantly to form phase I drug metabolites. Pooled microsomes from multiple donors can contain microorganisms from underlying microbial diseases.
Navid Jubaer
doaj   +1 more source

A Tetrazine‐Based Synthesis for Accessing Underutilized Aza‐Indole Analogues

Chemistry – A European Journal, EarlyView.
A nucleophilic aromatic substitution (SNAr)/Diels–Alder (DA)/retro Diels–Alder (rDA) reaction cascade has been developed to access pyrazolo[3,4‐c]pyridazine compounds. These cores have been further derivatized through divergent, late‐stage modifications to access various substitution patterns of the 3, 4, and 5 positions on the heterocyclic core ...
Evan Savelson, Katarina A. Selewski, Jetze J. Tepe   +2 more
wiley   +1 more source

Metabolism of palmitic acid in the subcellular fractions of mouse brain

Journal of Lipid Research, 1973
After an intracerebral injection of [14C]palmitic acid to C57BL/10J mice, the radioactivity in the brains decreased rapidly with time. The incorporated radioactivity was primarily in the 16:0 acyl groups of the diacyl phosphoglycerides at 1 and 3 days ...
Grace Y. Sun, Lloyd A. Horrocks
doaj  

Distribution of enzymes cleaving pyridine nucleotides in animal tissues [PDF]

, 1957
A number of enzymes capable of splitting the pyridine nucleotides have been found in animal tissues. A portion of the DPNase (1) that hydrolyzes the nicotinamide ribose bond of DPN and TPN was reported in the microsomes of rat liver (1).
Jacobson, K. Bruce, Kaplan, Nathan O.
core   +1 more source

Smooth microsomes. a trap for cholesteryl ester formed in hepatic microsomes.

Journal of Biological Chemistry, 1980
Acyl-CoA:cholesterol acyltransferase was found predominantly (85%) in RNA-rich microsomes, the rest being in RNA-poor and smooth microsomes. However, the esterified cholesterol concentration of smooth microsomes was 2-fold greater than that of RNA-rich microsomes, suggesting the possibility of an interaction between RNA-rich and smooth microsomes.
S Hashimoto, A M Fogelman
openaire   +3 more sources