Results 61 to 70 of about 81,174 (219)

Transport of Cytoplasmically Synthesized Proteins into the Mitochondria in a Cell Free System from Neurospora crassa [PDF]

, 1977
Synthesis and transport of mitochondrial proteins were followed in a cell-free homogenate of Neurospora crassa in which mitochondrial translation was inhibited. Proteins synthesized on cytoplasmic ribosomes are transferred into the mitochondrial fraction.
Andrews T. M., Bingham R. W., Blair G. E., Davidian N. M., Dobberstein B., Dolken G., Gaitskhoki V. S., Godinot C., Gonzalez-Cadavid N. F., Gonzalez-Cadavid N. F., Grollmann A. P., Hallermayer G., Kadenbach B., Kadenbach B., Kadenbach B., Kellems R. E., Kellems R. E., Kellems R. E., Kellems R. E., Marra E., Milstein C., Morris A., O'Brien R. L., Pfaff E., Redman C. M., Shore G. C., Takanami M., Tata J. R., Weiss H., Wojtczak L., Wojtczak L.   +30 more
core   +1 more source

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

Drug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis, Tiia  Kuuranne, Hans  Geyer   +2 more
wiley   +1 more source

Biogenesis of Cytochrome c in Neurospora crassa [PDF]

, 1978
# 1. Precipitating antibodies specific for apocytochrome c and holocytochrome c, respectively, were employed to study synthesis and intracellular transport of cytochrome c in Neurospora in vitro. # 2.
Korb, Harald, Neupert, Walter
core   +1 more source

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

Drug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer, Maria Carmela Emanuele, Brianna N. Stang, Katleen Van Uytfanghe, Jessica Masson, Xavier Bouvot, Catherine Lamoureux, Alessandro Proposito, Fabiano Reniero, Margaret V. Holland, Alex J. Krotulski, Luisa Mannina, Christophe P. Stove, Claude Guillou   +13 more
wiley   +1 more source

Gel Electrophoretic Detection of Black Market ACE‐031

Drug Testing and Analysis, EarlyView.
This article presents a study on black market ACE‐031 products and their detection by gel‐electrophoresis and Western blotting. Of the 14 tested products, only 12 contained an ACVR2B‐immunoreactive protein. However, mass spectrometry revealed that the products did not contain the ACVR2B‐Fc fusion protein ACE‐031 but instead the full‐length human ...
Christian Reichel, Thomas Filip, Günter Gmeiner, Mario Thevis   +3 more
wiley   +1 more source

Kinetic Studies on the Transport of Cytoplasmically Synthesized Proteins into the Mitochondria in Intact Cells of Neurospora crassa [PDF]

, 1977
The transport of cytoplasmically synthesized mitochondrial proteins was investigated in whole cells of Neurospora crassa, using dual labelling and immunological techniques.
Hallermayer, Gerhard, Neupert, Walter, Zimmermann, Richard   +2 more
core   +1 more source

Metabolic Identification Based on Proposed Mass Fragmentation Pathways of the Anabolic Steroid Bolasterone by Gas Chromatography Tandem Mass Spectrometry

Drug Testing and Analysis, EarlyView.
The metabolism of bolasterone in liver microsomes and in urine samples of rats orally treated was evaluated due to no availability of its extensive metabolism studies. Its mono‐ and di‐hydroxylated metabolites were detected by GC‐EI‐MS/MS, and the fragmentation pathways of metabolites were suggested.
Anca Raluca Muresan, Khandoker Asiqur Rahaman, Farzana Binte Rafique, Junghyun Son, Min‐Jung Kang, Oh‐Seung Kwon   +5 more
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

The Chicken Egg Genotoxicity Assay (CEGA): Assessing Target Tissue Exposure and Metabolism in the Embryo‐Fetal Chicken Livers

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The Chicken Egg Genotoxicity Assay (CEGA) is an avian egg‐based model that utilizes the livers of developing chicken embryo‐fetuses to assess the ability of chemicals to produce direct DNA damage. The main goal of the study was to evaluate target tissue exposure and metabolism in the CEGA to assess its suitability as a biologically relevant ...
Yax Thakkar, T. Kobets, Anne Marie Api, J. D. Duan, G. M. Williams   +4 more
wiley   +1 more source

Guidelines for Studying the Oxidative Stress Damage Model on Drosophila melanogaster

Future Postharvest and Food, EarlyView.
This guideline introduced Drosophila as a research model to summarize in detail the research methods of indicators that can characterize oxidative stress. It generally includes four aspects such as generation of ROS, damage caused by ROS, antioxidant defense, and cell stress repair and apoptosis.
Quanyong Wu
wiley   +1 more source