Results 1 to 10 of about 359,607 (329)
Structure Determination of Microtubules and Pili: Past, Present, and Future Directions
Frontiers in Molecular Biosciences, 2022 Historically proteins that form highly polymeric and filamentous assemblies have been notoriously difficult to study using high resolution structural techniques.
James A. Garnett, Joseph Atherton
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SARM1 Suppresses Axon Branching Through Attenuation of Axonal Cytoskeletal Dynamics
Frontiers in Molecular Neuroscience, 2022 Axon branching is a fundamental aspect of neuronal morphogenesis, neuronal circuit formation, and response of the nervous system to injury. Sterile alpha and TIR motif containing 1 (SARM1) was initially identified as promoting Wallerian degeneration of ...
Andrea Ketschek +3 more
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The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition [PDF]
Open Biology, 2016 Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice.
Jennifer T. Patel +5 more
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eLife, 2022 Kinesin superfamily proteins are microtubule-based molecular motors driven by the energy of ATP hydrolysis. Among them, the kinesin-4 family is a unique motor that inhibits microtubule dynamics. Although mutations of kinesin-4 cause several diseases, its
Shinya Taguchi +13 more
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Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies
eLife, 2022 The cytoskeleton – a collection of polymeric filaments, molecular motors, and crosslinkers – is a foundational example of active matter, and in the cell assembles into organelles that guide basic biological functions.
Wen Yan +6 more
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Microtubules and Microtubule-Associated Proteins [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell. Key to these functions is the fact that microtubules are "dynamic." As with actin, the polymer dynamics are driven by ...
Holly V. Goodson, Erin M. Jonasson
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Age-dependent increase of cytoskeletal components in sensory axons in human skin
Frontiers in Cell and Developmental Biology, 2022 Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites.
Klara Metzner +17 more
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Nanomechanics of Microtubules [PDF]
Physical Review Letters, 2002 We have determined the mechanical anisotropy of a single microtubule by simultaneously measuring the Young's and the shear moduli in vitro. This was achieved by elastically deforming the microtubule deposited on a substrate tailored by electron-beam lithography with a tip of an atomic force microscope.
B. Babić +9 more
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Isolation of Microtubules and Microtubule Proteins
Current Protocols in Cell Biology, 2008 AbstractThis unit describes various protocols for the isolation and purification of the main constituents of microtubules, chiefly α‐ and β‐tubulin, and the most significant microtubule associated proteins (MAPs), specifically MAP1A, MAP1B, MAP2, and tau.
Ávila, Jesús +3 more
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Cell Motility and the Cytoskeleton, 1999 The regulation of microtubule stability by severing of the polymer along its length is a newly appreciated and potentially important mechanism for controlling microtubule function. Microtubule severing occurs in living cells, but direct observation of this event is infrequent.
L M, Quarmby, T A, Lohret
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