Results 1 to 10 of about 417,156 (275)
Microtubules and Microtubule-Associated Proteins. [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell.
H. Goodson, Erin M. Jonasson
semanticscholar +3 more sources
Microtubules gate tau condensation to spatially regulate microtubule functions. [PDF]
Nature Cell Biology, 2019 Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia1, yet the physiological state of tau molecules within cells remains unclear.
A Ettinger +47 more
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The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition [PDF]
Open Biology, 2016 Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice.
Jennifer T. Patel +5 more
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Structure Determination of Microtubules and Pili: Past, Present, and Future Directions
Frontiers in Molecular Biosciences, 2022 Historically proteins that form highly polymeric and filamentous assemblies have been notoriously difficult to study using high resolution structural techniques.
James A. Garnett, Joseph Atherton
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SARM1 Suppresses Axon Branching Through Attenuation of Axonal Cytoskeletal Dynamics
Frontiers in Molecular Neuroscience, 2022 Axon branching is a fundamental aspect of neuronal morphogenesis, neuronal circuit formation, and response of the nervous system to injury. Sterile alpha and TIR motif containing 1 (SARM1) was initially identified as promoting Wallerian degeneration of ...
Andrea Ketschek +3 more
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LKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiation. [PDF]
PLoS ONE, 2012 Skeletal muscle myoblast differentiation and fusion into multinucleate myotubes is associated with dramatic cytoskeletal changes. We find that microtubules in differentiated myotubes are highly stabilized, but premature microtubule stabilization blocks ...
Isma Mian +5 more
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The ability to induce microtubule acetylation is a general feature of formin proteins. [PDF]
PLoS ONE, 2012 Cytoplasmic microtubules exist as distinct dynamic and stable populations within the cell. Stable microtubules direct and maintain cell polarity and it is thought that their stabilization is dependent on coordinative organization between the microtubule ...
Susan F Thurston +4 more
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eLife, 2022 Kinesin superfamily proteins are microtubule-based molecular motors driven by the energy of ATP hydrolysis. Among them, the kinesin-4 family is a unique motor that inhibits microtubule dynamics. Although mutations of kinesin-4 cause several diseases, its
Shinya Taguchi +13 more
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Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies
eLife, 2022 The cytoskeleton – a collection of polymeric filaments, molecular motors, and crosslinkers – is a foundational example of active matter, and in the cell assembles into organelles that guide basic biological functions.
Wen Yan +6 more
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Nanomechanics of Microtubules [PDF]
Physical Review Letters, 2002 We have determined the mechanical anisotropy of a single microtubule by simultaneously measuring the Young's and the shear moduli in vitro. This was achieved by elastically deforming the microtubule deposited on a substrate tailored by electron-beam lithography with a tip of an atomic force microscope.
B. Babić +9 more
openaire +4 more sources