Results 1 to 10 of about 453,492 (382)

CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre through phase separation

eLife, 2022
Microtubules are dynamic polymers consisting of αβ-tubulin heterodimers. The initial polymerization process, called microtubule nucleation, occurs spontaneously via αβ-tubulin.
Tsuyoshi Imasaki, Satoshi Kikkawa, Shinsuke Niwa, Yumiko Saijo-Hamano, Hideki Shigematsu, Kazuhiro Aoyama, Kaoru Mitsuoka, Takahiro Shimizu, Mari Aoki, Ayako Sakamoto, Yuri Tomabechi, Naoki Sakai, Mikako Shirouzu, Shinya Taguchi, Yosuke Yamagishi, Tomiyoshi Setsu, Yoshiaki Sakihama, Eriko Nitta, Masatoshi Takeichi, Ryo Nitta   +19 more
doaj   +1 more source

Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

Molecules, 2016
While evaluating a large library of compounds designed to inhibit microtubule polymerization, we identified four compounds that have unique effects on microtubules.
Cristina C. Rohena, April L. Risinger, Ravi Kumar Vyas Devambatla, Nicholas F. Dybdal-Hargreaves, Roma Kaul, Shruti Choudhary, Aleem Gangjee, Susan L. Mooberry   +7 more
doaj   +1 more source

α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization

eLife, 2022
The centrosome composed of a pair of centrioles (mother and daughter) and pericentriolar material, and is mainly responsible for microtubule nucleation and anchorage in animal cells.
Dandan Ma, Fulin Wang, Rongyi Wang, Yingchun Hu, Zhiquan Chen, Ning Huang, Yonglu Tian, Yuqing Xia, Junlin Teng, Jianguo Chen   +9 more
doaj   +1 more source

The role of microtubule movement in bidirectional organelle transport [PDF]

, 2008
We study the role of microtubule movement in bidirectional organelle transport in Drosophila S2 cells and show that EGFP-tagged peroxisomes in cells serve as sensitive probes of motor induced, noisy cytoskeletal motions.
A. E. X. Brown, Amblard, B. Blehm, Baas, C. Kural, Caspi, Gittes, Gross, H. Kim, I. M. Kulic, Keating, Lau, Martin, Orokos, P. C. Nelson, P. R. Selvin, Pangarkar, V. I. Gelfand, Vale, Wang, Welte, Welte   +21 more
core   +4 more sources

Lessons from in vitro reconstitution analyses of plant microtubule-associated proteins

Frontiers in Plant Science, 2014
Plant microtubules, composed of tubulin GTPase, are irreplaceable cellular components that regulate the directions of cell expansion and cell division, chromosome segregation and cell plate formation.
Takahiro eHamada
doaj   +1 more source

Microtubule integrity regulates budding yeast RAM pathway gene expression

Frontiers in Cell and Developmental Biology, 2022
During mitosis, cells must spatiotemporally regulate gene expression programs to ensure accurate cellular division. Failures to properly regulate mitotic progression result in aneuploidy, a hallmark of cancer.
Cameron Howard Lee, Sue Biggins
doaj   +1 more source

Dynamics of Microtubule Growth and Catastrophe [PDF]

, 2007
We investigate a simple model of microtubule dynamics in which a microtubule evolves by: (i) attachment of guanosine triphosphate (GTP) to its end at rate lambda, (ii) GTP converting irreversibly to guanosine diphosphate (GDP) at rate 1, and (iii ...
Antal, T., Chakraborty, B., Krapivsky, P. L., Mailman, M., Redner, S.   +4 more
core   +1 more source

Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction

Nature, 2020
Leucine-rich repeat kinase 2 ( LRRK2 ) is the most commonly mutated gene in familial Parkinson’s disease 1 and is also linked to its idiopathic form 2 .
C. Deniston, J. Salogiannis, J. Salogiannis, S. Mathea, D. Snead, Indrajit Lahiri, Indrajit Lahiri, M. Matyszewski, O. Donosa, R. Watanabe, J. Böhning, J. Böhning, A. Shiau, A. Shiau, S. Knapp, E. Villa, Samara L. Reck-Peterson, Samara L. Reck-Peterson, A. Leschziner   +18 more
semanticscholar   +1 more source

Neuroprotective effect of rapamycin on spinal cord injury via activation of the Wnt/β-catenin signaling pathway

Neural Regeneration Research, 2015
The Wnt/β-catenin signaling pathway plays a crucial role in neural development, axonal guidance, neuropathic pain remission and neuronal survival. In this study, we initially examined the effect of rapamycin on the Wnt/β-catenin signaling pathway after ...
Kai Gao, Yan-song Wang, Ya-jiang Yuan, Zhang-hui Wan, Tian-chen Yao, Hai-hong Li, Pei-fu Tang, Xi-fan Mei   +7 more
doaj   +1 more source

Tubulin bond energies and microtubule biomechanics determined from nanoindentation in silico [PDF]

, 2015
Microtubules, the primary components of the chromosome segregation machinery, are stabilized by longitudinal and lateral non-covalent bonds between the tubulin subunits.
Ataullakhanov, Fazly I., Barsegov, Valeri, Dima, Ruxandra I., Grishchuk, Ekaterina L., Kholodov, Yaroslav, Kononova, Olga, Marx, Kenneth A., Theisen, Kelly E.   +7 more
core   +1 more source