The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition [PDF]
Open Biology, 2016 Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice.
Jennifer T. Patel +5 more
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Tubulin Polymerization Promoting Protein Affects the Circadian Timing System in C57Bl/6 Mice
Journal of Circadian Rhythms, 2021 The circadian timing system (CTS) is a complex set of cyclic cellular mechanisms which serve to synchronize discrete cell groups across multiple organ systems to adapt the body’s physiology to a (roughly) 24-hour clock.
Eric Barbato +2 more
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Tubulin Post-translational Modifications: Potential Therapeutic Approaches to Heart Failure
Frontiers in Cell and Developmental Biology, 2022 In recent decades, advancing insights into the mechanisms of cardiac dysfunction have focused on the involvement of microtubule network. A variety of tubulin post-translational modifications have been discovered to fine-tune the microtubules’ properties ...
Chang Liu +3 more
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Nde1 and Ndel1: Outstanding Mysteries in Dynein-Mediated Transport
Frontiers in Cell and Developmental Biology, 2022 Cytoplasmic dynein-1 (dynein) is the primary microtubule minus-end directed molecular motor in most eukaryotes. As such, dynein has a broad array of functions that range from driving retrograde-directed cargo trafficking to forming and focusing the ...
Sharon R. Garrott +4 more
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Expression levels of a kinesin-13 microtubule depolymerase modulates the effectiveness of anti-microtubule agents. [PDF]
PLoS ONE, 2010 Chemotherapeutic drugs often target the microtubule cytoskeleton as a means to disrupt cancer cell mitosis and proliferation. Anti-microtubule drugs inhibit microtubule dynamics, thereby triggering apoptosis when dividing cells activate the mitotic ...
Gregory V Schimizzi +2 more
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WDR47 protects neuronal microtubule minus ends from katanin-mediated severing
Cell Reports, 2021 Summary: Axons and dendrites are long extensions of neurons that contain arrays of noncentrosomal microtubules. Calmodulin-regulated spectrin-associated proteins (CAMSAPs) bind to and stabilize free microtubule minus ends and are critical for proper ...
Robin R. Buijs +9 more
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Self-assembly of pericentriolar material in interphase cells lacking centrioles
eLife, 2022 The major microtubule-organizing center (MTOC) in animal cells, the centrosome, comprises a pair of centrioles surrounded by pericentriolar material (PCM), which nucleates and anchors microtubules. Centrosome assembly depends on PCM binding to centrioles,
Fangrui Chen +12 more
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Micron-scale geometrical features of microtubules as regulators of microtubule organization
eLife, 2021 The organization of micron-sized, multi-microtubule arrays from individual microtubules is essential for diverse cellular functions. The microtubule polymer is largely viewed as a passive building block during the organization process.
Nandini Mani +2 more
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Autoregulatory control of microtubule binding in doublecortin-like kinase 1
eLife, 2021 The microtubule-associated protein, doublecortin-like kinase 1 (DCLK1), is highly expressed in a range of cancers and is a prominent therapeutic target for kinase inhibitors. The physiological roles of DCLK1 kinase activity and how it is regulated remain
Regina L Agulto +8 more
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Lessons from in vitro reconstitution analyses of plant microtubule-associated proteins
Frontiers in Plant Science, 2014 Plant microtubules, composed of tubulin GTPase, are irreplaceable cellular components that regulate the directions of cell expansion and cell division, chromosome segregation and cell plate formation.
Takahiro eHamada
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