Results 1 to 10 of about 329,640 (294)
Microtubules and Microtubule-Associated Proteins [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell. Key to these functions is the fact that microtubules are "dynamic." As with actin, the polymer dynamics are driven by ...
Holly V, Goodson, Erin M, Jonasson
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The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition [PDF]
Open Biology, 2016 Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice.
Jennifer T. Patel +5 more
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Expression levels of a kinesin-13 microtubule depolymerase modulates the effectiveness of anti-microtubule agents. [PDF]
PLoS ONE, 2010 Chemotherapeutic drugs often target the microtubule cytoskeleton as a means to disrupt cancer cell mitosis and proliferation. Anti-microtubule drugs inhibit microtubule dynamics, thereby triggering apoptosis when dividing cells activate the mitotic ...
Gregory V Schimizzi +2 more
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eLife, 2022 Bidirectional cargo transport in neurons requires competing activity of motors from the kinesin-1, -2, and -3 superfamilies against cytoplasmic dynein-1.
Allison M Gicking +6 more
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TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes [PDF]
Open Biology, 2014 Chromosomal instability can arise from defects in chromosome–microtubule attachment. Using a variety of drug treatments, we show that TAO1 kinase is required for ensuring the normal congression of chromosomes.
Roshan L. Shrestha +5 more
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Animals, 2022 Alveolar echinococcosis (AE), caused by infection with the larvae of Echinococcus multilocularis, is a neglected tropical disease and zoonosis that causes remarkable morbidity in humans and has economic importance in the livestock industry worldwide. The
Qiqi Shi +4 more
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Pharmaceutics, 2022 Tubulin is an integral part of the cytoskeleton and plays a pivotal role in cellular signaling, maintenance, and division. β-tubulin is also the molecular target for taxane compounds such as docetaxel (DTX) and cabazitaxel (CTX), both first-line ...
Alan Alfano +4 more
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Cell Motility and the Cytoskeleton, 1999 The regulation of microtubule stability by severing of the polymer along its length is a newly appreciated and potentially important mechanism for controlling microtubule function. Microtubule severing occurs in living cells, but direct observation of this event is infrequent.
L M, Quarmby, T A, Lohret
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Molecules, 2022 Scoulerine is a natural compound that is known to bind to tubulin and has anti-mitotic properties demonstrated in various cancer cells. Its molecular mode of action has not been precisely known.
Mahshad Moshari +4 more
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Frontiers in Immunology, 2022 Cytotoxic T lymphocytes (CTLs) play an integral role in the adaptive immune response by killing infected cells. Antigen presenting cells (APCs), such as dendritic cells, present pathogenic peptides to the T cell receptor on the CTL surface and co ...
Aashli Pathni +11 more
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