Results 1 to 10 of about 397,871 (335)
The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition [PDF]
Open Biology, 2016 Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice.
Jennifer T. Patel +5 more
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Abstract P-33: Structural Basis for the Growing Microtubule End Recognition by End Binding Proteins [PDF]
International Journal of Biomedicine, 2021 Background: Eukaryotic end binding proteins (EBs) can follow the growing microtubule end. EBs play a crucial role in microtubule dynamic instability and promote simultaneously growth rate and catastrophe frequency.
Alena V. Korshunova
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Expression levels of a kinesin-13 microtubule depolymerase modulates the effectiveness of anti-microtubule agents. [PDF]
PLoS ONE, 2010 Chemotherapeutic drugs often target the microtubule cytoskeleton as a means to disrupt cancer cell mitosis and proliferation. Anti-microtubule drugs inhibit microtubule dynamics, thereby triggering apoptosis when dividing cells activate the mitotic ...
Gregory V Schimizzi +2 more
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Microtubules and Microtubule-Associated Proteins [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell. Key to these functions is the fact that microtubules are "dynamic." As with actin, the polymer dynamics are driven by ...
Holly V. Goodson, Erin M. Jonasson
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Dynamics and length distributions of microtubules with a multistep catastrophe mechanism
New Journal of Physics, 2023 Regarding the experimental observation that microtubule (MT) catastrophe can be described as a multistep process, we extend the Dogterom–Leibler model for dynamic instability in order to discuss the effect that such a multistep catastrophe mechanism has ...
Felix Schwietert +2 more
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eLife, 2022 Heterozygous, missense mutations in α- or β-tubulin genes are associated with a wide range of human brain malformations, known as tubulinopathies. We seek to understand whether a mutation’s impact at the molecular and cellular levels scale with the ...
Katelyn J Hoff +4 more
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Chemomechanical Simulation of Microtubule Dynamics With Explicit Lateral Bond Dynamics
Frontiers in Physics, 2021 We introduce and parameterize a chemomechanical model of microtubule dynamics on the dimer level, which is based on the allosteric tubulin model and includes attachment, detachment and hydrolysis of tubulin dimers as well as stretching of lateral bonds ...
Matthias Schmidt, Jan Kierfeld
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Nanomechanics of Microtubules [PDF]
Physical Review Letters, 2002 We have determined the mechanical anisotropy of a single microtubule by simultaneously measuring the Young's and the shear moduli in vitro. This was achieved by elastically deforming the microtubule deposited on a substrate tailored by electron-beam lithography with a tip of an atomic force microscope.
B. Babić +9 more
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Vibrations in Microtubules [PDF]
Journal of Biological Physics, 1997 Vibrations in microtubules and actin filaments are analysed using amethod similar to that employed for description of lattice vibrationsin solid state physics. The derived dispersion relations show thatvibrations in microtubules can have optical and acoustical branches.The highest frequency of vibrations in microtubules and in actinfilaments is of the ...
Jiří Pokorný +5 more
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Lessons from in vitro reconstitution analyses of plant microtubule-associated proteins
Frontiers in Plant Science, 2014 Plant microtubules, composed of tubulin GTPase, are irreplaceable cellular components that regulate the directions of cell expansion and cell division, chromosome segregation and cell plate formation.
Takahiro eHamada
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