Results 11 to 20 of about 141,824 (175)

Actin–microtubule coordination at growing microtubule ends [PDF]

Nature Communications, 2014
To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood.
Preciado López, Magdalena, Huber, Florian, Grigoriev, Ilya, Steinmetz, Michel O., Akhmanova, Anna, Koenderink, Gijsje H., Dogterom, Marileen   +6 more
openaire   +6 more sources

Microtubules, microtubule-interfering agents and apoptosis.

Apoptosis : an international journal on programmed cell death, 2003
Microtubules are dynamic polymers that play crucial roles in a large number of cellular functions. Their pivotal role in mitosis makes them a target for the development of anticancer drugs. Microtubule-damaging agents suppress microtubule dynamics, leading to disruption of the mitotic spindle in dividing cells, cell cycle arrest at M phase, and late ...
Mollinedo, Faustino, Gajate, Consuelo
openaire   +4 more sources

Formins and microtubules

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010
Formins have recently been recognized as prominent regulators of the microtubule (MT) cytoskeleton where they modulate the dynamics of selected MTs in interphase and mitosis. The association of formins with the MT cytoskeleton and their action on MT dynamics are relatively unexplored areas, yet growing evidence supports a direct role in their ...
Gregg G. Gundersen, Francesca Bartolini
openaire   +3 more sources

A "MICROTUBULE" IN A BACTERIUM [PDF]

The Journal of Cell Biology, 1967
A study of the anchorage of the flagella in swarmers of Proteus mirabilis led to the incidental observation of microtubules. These microtubules were found in thin sections and in whole mount preparations of cells from which most of the content had been released by osmotic shock before staining negatively with potassium phosphotungstate (PTA).
Judith F. M. Hoeniger, Woutera van Iterson, Eva Nijman van Zanten   +2 more
openaire   +3 more sources

Microtubule-severing enzymes: From cellular functions to molecular mechanism. [PDF]

, 2018
Microtubule-severing enzymes generate internal breaks in microtubules. They are conserved in eukaryotes from ciliates to mammals, and their function is important in diverse cellular processes ranging from cilia biogenesis to cell division, phototropism ...
Ahmad, Akhmanova, Akhmanova, Allison, Antonina Roll-Mecak, Aubin-Tam, Banks, Barton, Benz, Bichet, Burk, Burk, Carlier, Carlier, Carlier, Charafeddine, Cheung, Chi, Connell, Denton, DeSantis, DesMarais, Dominguez, Dong, Doyle, Dymek, Dymek, Díaz-Valencia, Eckert, Evans, Francis J. McNally, Ganem, Gates, Grode, Guizetti, Han, Hara, Hartman, Hartman, Hawkins, Hazan, Hu, Hu, Iwaya, Jiang, Jiang, Jiang, Johjima, Joly, Kasher, Keating, Lacroix, Lata, Lee, Leo, Lindeboom, Liu, Loughlin, Lundin, Lučič, Maillard, Mains, Mao, Matsuo, McNally, McNally, McNally, McNally, McNally, McNally, Minoura, Mishra-Gorur, Mitchison, Monroe, Moretti, Mukherjee, Murata, Nakamura, Nicklas, Nithianantham, Olivares, Park, Peng, Portis, Puchades, Qiang, Rao, Reid, Rezabkova, Ribbeck, Rogers, Roll-Mecak, Roll-Mecak, Roll-Mecak, Roll-Mecak, Sharma, Sharp, Shaw, Sherwood, Sonbuchner, Srayko, Stamatakis, Stewart, Stone, Tao, Taylor, Ti, Tirnauer, Tran, Trotta, Vale, Valenstein, Vemu, Vemu, Vietri, Walker, Wang, Waterman-Storer, Wen, White, Whitehead, Wightman, Yang, Yang, Yang, Yu, Zehr, Zhang, Zhang, Zhang, Zhao   +130 more
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SSNA1 stabilizes dynamic microtubules and detects microtubule damage [PDF]

eLife, 2021
Sjögren’s syndrome nuclear autoantigen-1 (SSNA1/NA14) is a microtubule-associated protein with important functions in cilia, dividing cells, and developing neurons. However, the direct effects of SSNA1 on microtubules are not known. We employed in vitro reconstitution with purified proteins and TIRF microscopy to investigate the activity of human SSNA1
Elizabeth J Lawrence, Goker Arpag, Cayetana Arnaiz, Marija Zanic   +3 more
openaire   +4 more sources

Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]

, 1996
In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M., Félix, M. A., Guet, C. C., Leibler, S.   +3 more
core   +2 more sources

The life of a microtubule

Molecular Biology of the Cell, 2018
The Minisymposium “The Life of a Microtubule: Birth, Dynamics and Function†highlighted new findings on how microtubules (MTs) are made, how their length and spatial organization is regulated, and finally how they contribute to cellular functions.
Dixit, Ram, Petry, Sabine
openaire   +4 more sources

Measuring and modeling polymer gradients argues that spindle microtubules regulate their own nucleation

, 2017
Spindles are self-organized microtubule-based structures that segregate chromosomes during cell division. The mass of the spindle is controlled by the balance between microtubule turnover and nucleation. The mechanisms that control the spatial regulation
Foster, Peter J., Fürthauer, Sebastian, Kaye, Bryan, Needleman, Daniel J., Shelley, Michael J., Stiehl, Olivia   +5 more
core   +1 more source

The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubule. [PDF]

, 2011
There has been much effort in recent years aimed at understanding the molecular mechanism by which the Dam1 kinetochore complex is able to couple microtubule depolymerization to poleward movement. Both a biased diffusion and a forced walk model have been
Barnes, Georjana, Drubin, David, Liu, Jian, Nakajima, Yuko, Nogales, Eva, Ramey, Vincent H, Wang, Hong-Wei, Wong, Amanda   +7 more
core   +2 more sources