Results 11 to 20 of about 417,156 (275)

The role of microtubule movement in bidirectional organelle transport [PDF]

, 2008
We study the role of microtubule movement in bidirectional organelle transport in Drosophila S2 cells and show that EGFP-tagged peroxisomes in cells serve as sensitive probes of motor induced, noisy cytoskeletal motions.
A. E. X. Brown, Amblard, B. Blehm, Baas, C. Kural, Caspi, Gittes, Gross, H. Kim, I. M. Kulic, Keating, Lau, Martin, Orokos, P. C. Nelson, P. R. Selvin, Pangarkar, V. I. Gelfand, Vale, Wang, Welte, Welte   +21 more
core   +4 more sources

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Proceedings of the National Academy of Sciences of the United States of America, 1986
A monoclonal antibody to the microtubule-associated protein tau (tau) labeled some neurofibrillary tangles and plaque neurites, the two major locations of paired-helical filaments (PHF), in Alzheimer disease brain.
I. Grundke‐Iqbal, K. Iqbal, Y. Tung, M. Quinlan, H. Wiśniewski, L. Binder   +5 more
semanticscholar   +1 more source

Isolation of Microtubules and Microtubule Proteins

Current Protocols in Cell Biology, 2008
AbstractThis unit describes various protocols for the isolation and purification of the main constituents of microtubules, chiefly α‐ and β‐tubulin, and the most significant microtubule associated proteins (MAPs), specifically MAP1A, MAP1B, MAP2, and tau.
Ávila, Jesús, Soares, Helena, Fanarraga, Mónica L., Zabala, Juan Carlos   +3 more
openaire   +3 more sources

Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 [PDF]

, 2014
BACKGROUND: In the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
Liz, Márcia A., Mar, Fernando M., Marques, Ana M., Morgado, Marlene M., Pemble, Hayley, Pimentel, Helena I., Santos, Telma E., Sousa, Mónica M., Sousa, Vera F., Sutherland, Calum, Vieira, Sílvia, Wittmann, Torsten, Woodgett, James R.   +12 more
core   +4 more sources

Lessons from in vitro reconstitution analyses of plant microtubule-associated proteins

Frontiers in Plant Science, 2014
Plant microtubules, composed of tubulin GTPase, are irreplaceable cellular components that regulate the directions of cell expansion and cell division, chromosome segregation and cell plate formation.
Takahiro eHamada
doaj   +1 more source

Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction

Nature, 2020
Leucine-rich repeat kinase 2 ( LRRK2 ) is the most commonly mutated gene in familial Parkinson’s disease 1 and is also linked to its idiopathic form 2 .
C. Deniston, J. Salogiannis, J. Salogiannis, S. Mathea, D. Snead, Indrajit Lahiri, Indrajit Lahiri, M. Matyszewski, O. Donosa, R. Watanabe, J. Böhning, J. Böhning, A. Shiau, A. Shiau, S. Knapp, E. Villa, Samara L. Reck-Peterson, Samara L. Reck-Peterson, A. Leschziner   +18 more
semanticscholar   +1 more source

Age-dependent increase of cytoskeletal components in sensory axons in human skin

Frontiers in Cell and Developmental Biology, 2022
Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites.
Klara Metzner, Klara Metzner, Omar Darawsha, Mengzhe Wang, Nayana Gaur, Nayana Gaur, Yiming Cheng, Annekathrin Rödiger, Christiane Frahm, Otto W. Witte, Fabiana Perocchi, Fabiana Perocchi, Fabiana Perocchi, Hubertus Axer, Julian Grosskreutz, Julian Grosskreutz, Monika S. Brill, Monika S. Brill   +17 more
doaj   +1 more source

Microtubule severing [PDF]

Cell Motility and the Cytoskeleton, 1999
The regulation of microtubule stability by severing of the polymer along its length is a newly appreciated and potentially important mechanism for controlling microtubule function. Microtubule severing occurs in living cells, but direct observation of this event is infrequent.
L M, Quarmby, T A, Lohret
openaire   +2 more sources

Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

Molecules, 2016
While evaluating a large library of compounds designed to inhibit microtubule polymerization, we identified four compounds that have unique effects on microtubules.
Cristina C. Rohena, April L. Risinger, Ravi Kumar Vyas Devambatla, Nicholas F. Dybdal-Hargreaves, Roma Kaul, Shruti Choudhary, Aleem Gangjee, Susan L. Mooberry   +7 more
doaj   +1 more source

Tubulin bond energies and microtubule biomechanics determined from nanoindentation in silico [PDF]

, 2015
Microtubules, the primary components of the chromosome segregation machinery, are stabilized by longitudinal and lateral non-covalent bonds between the tubulin subunits.
Ataullakhanov, Fazly I., Barsegov, Valeri, Dima, Ruxandra I., Grishchuk, Ekaterina L., Kholodov, Yaroslav, Kononova, Olga, Marx, Kenneth A., Theisen, Kelly E.   +7 more
core   +1 more source