Results 21 to 30 of about 417,156 (275)

She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain

Nature Communications, 2017
Dynein is a microtubule motor the motility of which is affected by the microtubule-associated protein She1. Here, the authors show that She1 alters dynein stepping behavior and increases its microtubule affinity through simultaneous interactions with the
Kari H. Ecklund, Tatsuya Morisaki, Lindsay G. Lammers, Matthew G. Marzo, Timothy J. Stasevich, Steven M. Markus   +5 more
doaj   +1 more source

Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7. [PDF]

, 2018
Kinesin-4 motors play important roles in cell division, microtubule organization, and signaling. Understanding how motors perform their functions requires an understanding of their mechanochemical and motility properties.
Blasius, T Lynne, Cochran, Jared C, Grant, Barry J, Jariwala, Shashank, Verhey, Kristen J, Walker, Benjamin, Yue, Yang, Zhang, Stephanie   +7 more
core   +2 more sources

Actin–microtubule coordination at growing microtubule ends [PDF]

Nature Communications, 2014
To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood.
Preciado López, Magdalena, Huber, Florian, Grigoriev, Ilya, Steinmetz, Michel O., Akhmanova, Anna, Koenderink, Gijsje H., Dogterom, Marileen   +6 more
openaire   +6 more sources

Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport

Frontiers in Physiology, 2017
Connexin 43 (Cx43, encoded by GJA1) is a cell-cell communication gap junction protein expressed in all organ systems. It was recently found that GJA1 mRNA undergoes alternative translation to generate N-terminal truncated isoforms, of which GJA1-20k is ...
Ying Fu, Shan-Shan Zhang, Shaohua Xiao, Wassim A. Basheer, Rachel Baum, Irina Epifantseva, TingTing Hong, TingTing Hong, Robin M. Shaw, Robin M. Shaw   +9 more
doaj   +1 more source

Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]

, 1996
In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M., Félix, M. A., Guet, C. C., Leibler, S.   +3 more
core   +2 more sources

Formins and microtubules

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010
Formins have recently been recognized as prominent regulators of the microtubule (MT) cytoskeleton where they modulate the dynamics of selected MTs in interphase and mitosis. The association of formins with the MT cytoskeleton and their action on MT dynamics are relatively unexplored areas, yet growing evidence supports a direct role in their ...
Gregg G. Gundersen, Francesca Bartolini
openaire   +3 more sources

A de novo Mutation in the MTUS1 Gene Decreases the Risk of Non-compaction of Ventricular Myocardium via the Rac1/Cdc42 Pathway

Frontiers in Pediatrics, 2019
Background: The MTUS1 gene encodes a microtubule-associated protein involved in multiple processes including cell polarity and microtubule balance during myocardial development.Aims: To investigate the association between a de novo c.
Xuehan Bai, Xuehan Bai, Yuanlin Zhou, Na Ouyang, Na Ouyang, Lingjuan Liu, Lingjuan Liu, Xupei Huang, Jie Tian, Jie Tian, Tiewei Lv, Tiewei Lv   +11 more
doaj   +1 more source

The mechanism of kinesin inhibition by kinesin-binding protein

eLife, 2020
Subcellular compartmentalisation is necessary for eukaryotic cell function. Spatial and temporal regulation of kinesin activity is essential for building these local environments via control of intracellular cargo distribution.
Joseph Atherton, Jessica JA Hummel, Natacha Olieric, Julia Locke, Alejandro Peña, Steven S Rosenfeld, Michel O Steinmetz, Casper C Hoogenraad, Carolyn A Moores   +8 more
doaj   +1 more source

Tubulin/microtubules as novel clozapine targets

Neuropsychopharmacology Reports, 2022
Aim Clozapine is currently the only effective drug for treatment‐resistant schizophrenia; nonetheless, its pharmacological mechanism remains unclear, and its administration is limited because of severe adverse effects.
Mizuki Hino, Takeshi Kondo, Yasuto Kunii, Junya Matsumoto, Akira Wada, Shin‐ichi Niwa, Mitsutoshi Setou, Hirooki Yabe   +7 more
doaj   +1 more source

Cytokinesis in bloodstream stage Trypanosoma brucei requires a family of katanins and spastin [PDF]

, 2012
Microtubule severing enzymes regulate microtubule dynamics in a wide range of organisms and are implicated in important cell cycle processes such as mitotic spindle assembly and disassembly, chromosome movement and cytokinesis.
A Baines, A Errico, A Hemphill, A Karabay, A Roll-Mecak, A Roll-Mecak, A Schneider, A Schneider, A Woods, B Lacroix, B Wickstead, C Benz, C Hertz-Fowler, C Lu, C Vedrenne, Caroline Clucas, Corinna Benz, D Buster, D Spitznagel, D Zhang, D Zhang, Dan Zilberstein, DJ LaCount, DR Robinson, E Detmer, E Panteris, E Wirtz, EE Dymek, FJ Ahmad, FJ McNally, FJ McNally, G Burkard, GR Forsythe, H Sudo, H Sudo, H Sudo, HH Lee, HP Price, J Guizetti, J Van den Abbeele, JA Garcia-Salcedo, JA Schiel, JC Munday, JD Diaz-Valencia, Jeremy C. Mottram, JJ Hartman, JJ Hartman, JT Ma, JW Connell, K Gull, K McNally, K Toyo-oka, KJ Evans, KP Mcnally, KP McNally, KP Mcnally, KR Matthews, KY Chan, L Kohl, L Qiang, L Rindisbacher, M Agromayor, M Casanova, M Srayko, MQ Rasi, MR Dow, N Balaban, N Balaban, N Sharma, P Bastin, Q Meng, R Sasse, R Sharma, S Biebinger, S Kelly, S Monnerat, S Olego-Fernandez, S Redmond, S Vaughan, SG Lillico, SH Park, T Sherwin, T Sherwin, T Sherwin, Tansy C. Hammarton, TC Hammarton, TC Hammarton, TC Hammarton, TC Hammarton, W Yu, WQ Yu, Z Li, Z Li   +92 more
core   +5 more sources