Results 21 to 30 of about 359,607 (329)
Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]
, 1996 In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M. +3 more
core +2 more sources
eLife, 2020 Mutations in TUBB4A result in a spectrum of leukodystrophy including Hypomyelination with Atrophy of Basal Ganglia and Cerebellum (H-ABC), a rare hypomyelinating leukodystrophy, often associated with a recurring variant p.Asp249Asn (D249N).
Sunetra Sase +15 more
doaj +1 more source
Regulation of Tubulin Gene Expression: From Isotype Identity to Functional Specialization
Frontiers in Cell and Developmental Biology, 2022 Genomes of higher eukaryotes encode a large tubulin gene superfamily consisting of at least six α and six β-tubulin isotypes. While some α and β-tubulin isotypes are ubiquitously expressed, others are cell-type specific.
Ivana Gasic
doaj +1 more source
Actin–microtubule coordination at growing microtubule ends [PDF]
Nature Communications, 2014 To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood.
Preciado López, Magdalena +6 more
openaire +6 more sources
Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 [PDF]
, 2014 BACKGROUND: In the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
Liz, Márcia A. +12 more
core +4 more sources
chTOG is a conserved mitotic error correction factor
eLife, 2020 Accurate chromosome segregation requires kinetochores on duplicated chromatids to biorient by attaching to dynamic microtubules from opposite spindle poles, which exerts forces to bring kinetochores under tension.
Jacob A Herman +2 more
doaj +1 more source
Microtubules in Pancreatic β Cells: Convoluted Roadways Toward Precision
Frontiers in Cell and Developmental Biology, 2022 Pancreatic islet β cells regulate glucose homeostasis via glucose-stimulated insulin secretion (GSIS). Cytoskeletal polymers microtubules (MTs) serve as tracks for the transport and positioning of secretory insulin granules.
Kai M. Bracey +2 more
doaj +1 more source
Marine Drugs, 2018 Some antimicrobial peptides (AMPs) exhibit anti-cancer activity, acting on cancer cells either by causing membrane lysis or via intracellular effects. While intracellular penetration of AMPs has been shown to cause cancer cell death, the mechanisms of ...
Chen-Hung Ting +3 more
doaj +1 more source
eLife, 2022 Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT-based molecular motor dynein result in lissencephaly. However, a functional link between DCX and dynein has not been defined.
Xiaoqin Fu +7 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010 Formins have recently been recognized as prominent regulators of the microtubule (MT) cytoskeleton where they modulate the dynamics of selected MTs in interphase and mitosis. The association of formins with the MT cytoskeleton and their action on MT dynamics are relatively unexplored areas, yet growing evidence supports a direct role in their ...
Gregg G. Gundersen, Francesca Bartolini
openaire +3 more sources