Results 111 to 120 of about 335,784 (179)

Structural insights into the interplay between microtubule polymerases, γ-tubulin complexes and their receptors

Nature Communications
The γ-tubulin ring complex (γ-TuRC) is a structural template for controlled nucleation of microtubules from α/β-tubulin heterodimers. At the cytoplasmic side of the yeast spindle pole body, the CM1-containing receptor protein Spc72 promotes γ-TuRC ...
Anjun Zheng, Bram J. A. Vermeulen, Martin Würtz, Annett Neuner, Nicole Lübbehusen, Matthias P. Mayer, Elmar Schiebel, Stefan Pfeffer   +7 more
doaj   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons.

PLoS Biology, 2020
While many regulators of axon regeneration have been identified, very little is known about mechanisms that allow dendrites to regenerate after injury.
Derek M R Nye, Richard M Albertson, Alexis T Weiner, J Ian Hertzler, Matthew Shorey, Deborah C I Goberdhan, Clive Wilson, Kevin A Janes, Melissa M Rolls   +8 more
doaj   +1 more source

The centrosome and the mechanism of microtubule nucleation

The FASEB Journal, 2006
Microtubules are hollow polymers of α β‐tubulin that exhibit GTP‐dependent assembly dynamics and comprise a critical part of the eukaryotic cytoskeleton. Initiation of new microtubules in vivo requires γ‐tubulin, organized as an oligomer within the γ‐Tubulin Ring Complex (γ‐TuRC) of higher ...
Luke Rice, John Lyle, Michelle Moritz, David A. Agard   +3 more
openaire   +1 more source

Physical basis of large microtubule aster growth

eLife, 2016
Microtubule asters - radial arrays of microtubules organized by centrosomes - play a fundamental role in the spatial coordination of animal cells. The standard model of aster growth assumes a fixed number of microtubules originating from the centrosomes.
Keisuke Ishihara, Kirill S Korolev, Timothy J Mitchison   +2 more
doaj   +1 more source

Structural analysis of the role of TPX2 in branching microtubule nucleation

Journal of Cell Biology, 2017
The mitotic spindle consists of microtubules (MTs), which are nucleated by the &ggr;-tubulin ring complex (&ggr;-TuRC). How the &ggr;-TuRC gets activated at the right time and location remains elusive.
Raymundo Alfaro-Aco, Akanksha Thawani, S. Petry   +2 more
semanticscholar   +1 more source

The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules

Nature Communications, 2017
Microtubule organization requires γ-tubulin ring complexes (γTuRCs), but the mechanisms that control γTuRC-mediated microtubule nucleation are unclear.
Yuehong Shen, Pengfei Liu, Taolue Jiang, Yu Hu, Franco K. C. Au, Robert Z. Qi   +5 more
doaj   +1 more source

CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation.

PLoS Biology
The densely packed centromeric heterochromatin at minor and major satellites is comprised of H3K9me2/3 histones, the heterochromatin protein HP1α, and histone variants.
Gokul Gopinathan, Qian Xu, Xianghong Luan, Thomas G H Diekwisch   +3 more
doaj   +1 more source

Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity

Nature Communications, 2016
In mature neurons the centrosome no longer functions as the main microtubule organizer and it is unclear how ordered microtubule arrays are assembled. Here, the authors show that in post-mitotic neurons this process depends on non-centrosomal nucleation ...
Carlos Sánchez-Huertas, Francisco Freixo, Ricardo Viais, Cristina Lacasa, Eduardo Soriano, Jens Lüders   +5 more
doaj   +1 more source

Abl2 repairs microtubules and phase separates with tubulin to promote microtubule nucleation. [PDF]

Curr Biol, 2023
Duan D, Lyu W, Chai P, Ma S, Wu K, Wu C, Xiong Y, Sestan N, Zhang K, Koleske AJ.   +9 more
europepmc   +1 more source