Results 121 to 130 of about 335,784 (179)

Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes. [PDF]

J Cell Biol, 2023
Zhu Z, Becam I, Tovey CA, Elfarkouchi A, Yen EC, Bernard F, Guichet A, Conduit PT.   +7 more
europepmc   +1 more source

Conserved function of the HAUS6 calponin homology domain in anchoring augmin for microtubule branching

Nature Communications
Branching microtubule nucleation is a key mechanism for mitotic and meiotic spindle assembly and requires the hetero-octameric augmin complex. Augmin recruits the major microtubule nucleator, the γ-tubulin ring complex, to pre-existing microtubules to ...
Martin Würtz, Giulia Tonon, Bram J. A. Vermeulen, Maja Zezlina, Qi Gao, Annett Neuner, Angelika Seidl, Melanie König, Maximilian Harkenthal, Sebastian Eustermann, Sylvia Erhardt, Fabio Lolicato, Elmar Schiebel, Stefan Pfeffer   +13 more
doaj   +1 more source

Pathogenic variants of TUBB8 cause oocyte spindle defects by disrupting with EB1/CAKP5 interactions and potential treatment targeting microtubule acetylation through HDAC6 inhibition

Clinical and Translational Medicine
Background Numerous pathogenic variants causing human oocyte maturation arrest have been reported on the primate‐specific TUBB8 gene. The main etiology is the dramatic reduction of tubulin α/β dimer, but still large numbers of variants remain unexplained.
Hui Luo, Jianhua Chen, Cao Li, Tian Wu, Siyue Yin, Guangping Yang, Yipin Wang, Zhihan Guo, Saifei Hu, Yanni He, Yingnan Wang, Yao Chen, Youqiang Su, Congxiu Miao, Yun Qian, Ruizhi Feng   +15 more
doaj   +1 more source

An alternative splice isoform of mouse CDK5RAP2 induced cytoplasmic microtubule nucleation. [PDF]

IBRO Neurosci Rep, 2022
Nakamura A, Ikeda M, Kusayanagi S, Hayashi K.   +3 more
europepmc   +1 more source

The γ-TuRC: mastermind of multipurpose actions at the centrosome

Cellular and Molecular Life Sciences
The γ-Tubulin Ring Complex (γ-TuRC) comprised of γ-tubulin and γ-tubulin complex proteins (GCP2-6) serves as the main protein scaffold for microtubule nucleation in most animal cells.
Swarnendu Mukhopadhyay, Qi Gao, Tapas K. Manna, Elmar Schiebel   +3 more
doaj   +1 more source

NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis. [PDF]

Biol Open, 2022
Timón Pérez K, Scrofani J, Vernos I.
europepmc   +1 more source

Tubacin alleviate the reproductive toxicity of deoxynivalenol in mouse oocytes and zygotes via strengthening microtubule stability

Cell Communication and Signaling
Deoxynivalenol (DON) is one of the most common food contaminants, widely present in grain products. Studies using murine and porcine models show deoxynivalenol exposure impairs oocyte maturation and mitochondrial function; however, the exact mechanisms ...
Hui Luo, Jianhua Chen, Zhihan Guo, Yanyan Zhu, Yipin Wang, Tian Wu, Siyue Yin, Cao Li, Youqiang Su, Yao Chen, Yun Qian, Congxiu Miao, Ruizhi Feng   +12 more
doaj   +1 more source

The centrosomal recruitment of γ-tubulin and its microtubule nucleation activity is α-fodrin guided. [PDF]

Cell Cycle, 2023
Sreeja JS, Jyothy A, Nellikka RK, Ghorai S, Riya PA, James J, Sengupta S.   +6 more
europepmc   +1 more source

Reconstitution of Microtubule Nucleation In Vitro Reveals Novel Roles for Mzt1.

Curr Biol, 2023
Leong SL, Lynch EM, Zou J, Tay YD, Borek WE, Tuijtel MW, Rappsilber J, Sawin KE.   +7 more
europepmc   +1 more source

The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC). [PDF]

Elife, 2022
Rale MJ, Romer B, Mahon BP, Travis SM, Petry S.   +4 more
europepmc   +1 more source