Results 101 to 110 of about 211,422 (165)

Survivin modulates microtubule dynamics and nucleation throughout the cell cycle

, 2008
Survivin is a member of the chromosomal passenger complex implicated in kinetochore attachment, bipolar spindle formation, and cytokinesis. However, the mechanism by which survivin modulates these processes is unknown. Here, we show by time-lapse imaging
Islam, Ashraful, Altieri, Dario C., Canovas, Pedro, Doxsey, Stephen J., Rosa, Jack   +4 more
core   +1 more source

Regulation of microtubule nucleation in Schizosaccharomyces pombe: recruitment of Mto1 to the site of the prospective eMTOC [PDF]

, 2010
Mto1 recruits γ-tubulin to the sites of cytoplasmic microtubule nucleation in the fission yeast Schizosaccharomyces pombe. The regulation of Mto1 localisation is central to re-modelling of the microtubule cytoskeleton during the cell cycle.
Miller, Victoria Jane
core  

Abl2 repairs microtubules and phase separates with tubulin to promote microtubule nucleation. [PDF]

Curr Biol, 2023
Duan D, Lyu W, Chai P, Ma S, Wu K, Wu C, Xiong Y, Sestan N, Zhang K, Koleske AJ.   +9 more
europepmc   +1 more source

Characterization of TPX2 in Branching Microtubule Nucleation

, 2015
The process in which a cell parts into two daughter cells, or cell division, is highly dependent on the correct formation of the mitotic spindle, the array of microtubules that pulls the daughter chromosomes apart.
Octeau, David
core  

Conserved function of the HAUS6 calponin homology domain in anchoring augmin for microtubule branching

Nature Communications
Branching microtubule nucleation is a key mechanism for mitotic and meiotic spindle assembly and requires the hetero-octameric augmin complex. Augmin recruits the major microtubule nucleator, the γ-tubulin ring complex, to pre-existing microtubules to ...
Martin Würtz, Giulia Tonon, Bram J. A. Vermeulen, Maja Zezlina, Qi Gao, Annett Neuner, Angelika Seidl, Melanie König, Maximilian Harkenthal, Sebastian Eustermann, Sylvia Erhardt, Fabio Lolicato, Elmar Schiebel, Stefan Pfeffer   +13 more
doaj   +1 more source

Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes. [PDF]

J Cell Biol, 2023
Zhu Z, Becam I, Tovey CA, Elfarkouchi A, Yen EC, Bernard F, Guichet A, Conduit PT.   +7 more
europepmc   +1 more source

Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module

, 2020
Spindle assembly and function require precise control of microtubule nucleation and dynamics. The chromatin-driven spindle assembly pathway exerts such control locally in the vicinity of chromosomes. One of the key targets of this pathway is TPX2.
Johanna Roostalu (8458062), Nicholas I Cade (8273094), Thomas Surrey (53553)   +2 more
core  

Structural basis of protein condensation on microtubules underlying branching microtubule nucleation. [PDF]

Nat Commun, 2023
Guo C, Alfaro-Aco R, Zhang C, Russell RW, Petry S, Polenova T.   +5 more
europepmc   +1 more source

Pathogenic variants of TUBB8 cause oocyte spindle defects by disrupting with EB1/CAKP5 interactions and potential treatment targeting microtubule acetylation through HDAC6 inhibition

Clinical and Translational Medicine
Background Numerous pathogenic variants causing human oocyte maturation arrest have been reported on the primate‐specific TUBB8 gene. The main etiology is the dramatic reduction of tubulin α/β dimer, but still large numbers of variants remain unexplained.
Hui Luo, Jianhua Chen, Cao Li, Tian Wu, Siyue Yin, Guangping Yang, Yipin Wang, Zhihan Guo, Saifei Hu, Yanni He, Yingnan Wang, Yao Chen, Youqiang Su, Congxiu Miao, Yun Qian, Ruizhi Feng   +15 more
doaj   +1 more source

Localized RanGTP accumulation promotes microtubule nucleation at kinetochores in somatic mammalian cells

, 2008
Centrosomes are the major sites for microtubule nucleation in mammalian cells, although both chromatin- and kinetochore- mediated microtubule nucleation have been observed during spindle assembly.
Lavia P, De Luca M, Guarguaglini G, Degrassi F, Torosantucci L   +4 more
core