Results 81 to 90 of about 211,422 (165)
Regulation of branching microtubule nucleation
, 2019 The development, maintenance, and propagation of eukaryotic life require the accurate segregation of chromosomes by microtubule-based mitotic and meiotic spindles.
King, Matthew Ryan
core +1 more source
Cytoskeleton, Volume 83, Issue 10, Page 779-794, October 2026.ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong +7 more
wiley +1 more source
Direct induction of microtubule branching by microtubule nucleation factor SSNA1
, 2018 Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed microtubule seeds or from.
Nedozralova, H. +28 more
core +1 more source
Nature CommunicationsThe γ-tubulin ring complex (γ-TuRC) is a structural template for controlled nucleation of microtubules from α/β-tubulin heterodimers. At the cytoplasmic side of the yeast spindle pole body, the CM1-containing receptor protein Spc72 promotes γ-TuRC ...
Anjun Zheng +7 more
doaj +1 more source
The role of Rho GTPases in facial morphogenesis
Developmental Dynamics, Volume 255, Issue 10, Page 931-944, October 2026.The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley +1 more source
MedComm, Volume 7, Issue 10, October 2026.Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna +3 more
wiley +1 more source
The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons.
PLoS Biology, 2020 While many regulators of axon regeneration have been identified, very little is known about mechanisms that allow dendrites to regenerate after injury.
Derek M R Nye +8 more
doaj +1 more source
Posttranslational Modifications of p62/SQSTM1 in Health and Disease
MedComm, Volume 7, Issue 10, October 2026.Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang +8 more
wiley +1 more source
eLife, 2018 Stu2/XMAP215/ZYG-9/Dis1/Alp14/Msps/ch-TOG family members in association with with γ-tubulin complexes nucleate microtubules, but we know little about the interplay of these nucleation factors. Here, we show that the budding yeast Stu2 in complex with the
Judith Gunzelmann +6 more
doaj +1 more source
Cytoskeletal Dynamics in Cancer: From Pathogenesis to Treatment
MedComm, Volume 7, Issue 10, October 2026.This review systematically addresses the fundamental roles of the cytoskeleton (actin filaments, microtubules, and intermediate filaments) in cancer progression. We focus on how cytoskeletal dynamics regulate tumor proliferation, metastasis, and programmed cell death, while also modulating the immune microenvironment. Understanding these mechanisms may
Jie Chen +9 more
wiley +1 more source