Results 81 to 90 of about 335,784 (179)

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis

EMBO Journal, 2019
Cells going through mitosis undergo precisely timed changes in cell shape and organisation, which serve to ensure the fair partitioning of cellular components into the two daughter cells.
F. Farina, Nitya Ramkumar, L. Brown, Dureen Samandar Eweis, Jannis Anstatt, Thomas Waring, Jessica Bithell, G. Scita, M. Théry, L. Blanchoin, Tobias Zech, B. Baum   +11 more
semanticscholar   +1 more source

Robustness of Spontaneous Polarization Through Nonlinear Directional Antagonism Without Global Inhibition

Journal of the Chinese Chemical Society, EarlyView.
The conventional “local activation–global inhibition” (LAGI) models utilize mean‐field averaging inhibition to suppress distant activations. As the inhibition diminishes with distance, LAGI models struggle to achieve robust single‐axis polarity in large systems.
Chin‐Lin Guo, Chiao‐Yu Tseng
wiley   +1 more source

Microtubule nucleation by γ-tubulin complexes and beyond

Essays in Biochemistry, 2018
In this short review, we give an overview of microtubule nucleation within cells. It is nearly 30 years since the discovery of γ-tubulin, a member of the tubulin superfamily essential for proper microtubule nucleation in all eukaryotes.
Corinne A. Tovey, Paul T. Conduit
semanticscholar   +1 more source

Sperm Head–Tail Coupling Apparatus Diversity and Common Themes Among Species

Andrology, EarlyView.
ABSTRACT Background A stable connection between the sperm head (containing the nucleus and acrosome) and tail (containing the axoneme, mitochondrial sheath, and periaxonemal structures) is critical for fertility. This connection is mediated by a series of nuclear, cytoplasmic, and centriole components that make up the head–tail coupling apparatus (HTCA)
Danielle B. Buglak, Brian J. Galletta, Nasser M. Rusan   +2 more
wiley   +1 more source

The Dis1/Stu2/XMAP215 Family Gene FgStu2 Is Involved in Vegetative Growth, Morphology, Sexual and Asexual Reproduction, Pathogenicity and DON Production of Fusarium graminearum

Frontiers in Microbiology, 2020
The conserved Dis1/Stu2/XMAP215 microtubule association proteins (MAPs) family plays an important role in microtubule dynamics, nucleation, and kinetochore-microtubule attachments.
Yuanye Zhu, Yuanshuai Zhang, Na Liu, Weichao Ren, Yiping Hou, Yabing Duan, Xiushi Song, Mingguo Zhou   +7 more
doaj   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Collective dynamics of actin and microtubule and its crosstalk mediated by FHDC1

Frontiers in Cell and Developmental Biology
The coordination between actin and microtubule network is crucial, yet this remains a challenging problem to dissect and our understanding of the underlying mechanisms remains limited.
Chee San Tong, Chee San Tong, Maohan Su, Maohan Su, Maohan Su, He Sun, Xiang Le Chua, Xiang Le Chua, Ding Xiong, Su Guo, Ravin Raj, Nicole Wen Pei Ong, Ann Gie Lee, Yansong Miao, Min Wu, Min Wu, Min Wu   +16 more
doaj   +1 more source

Measuring and modeling polymer concentration profiles near spindle boundaries argues that spindle microtubules regulate their own nucleation

New Journal of Physics, 2018
Spindles are self-organized microtubule-based structures that segregate chromosomes during cell division. The mass of the spindle is controlled by the balance between microtubule turnover and nucleation. The mechanisms that control the spatial regulation
Bryan Kaye, Olivia Stiehl, Peter J Foster, Michael J Shelley, Daniel J Needleman, Sebastian Fürthauer   +5 more
doaj   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source