Results 71 to 80 of about 211,422 (165)

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

The Role of Actin‐Filament Bundling Protein, Fimbrin Sac6, and Type‐V Myosin Myo2, in the Motion of the SUN‐Domain Protein, Mps3, During Yeast Meiosis

Genes to Cells, Volume 31, Issue 6, November 2026.
Type‐V myosin (Myo2) promotes the motion of Mps3 patches on the nuclear membrane during yeast meiosis. On the other hand, Sac6 fimbrin, which bundles actin filaments, is not critical for the motion of Mps3, suggesting the role of a few actin filaments in the Mps3 motion.
Shuangping Cheng, Tadasu Nozaki, Yurika Fujita, Masaru Ito, Akira Shinohara   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, Volume 600, Issue 20, Page 3073-3088, October 2026.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Investigating the Biochemical Interaction between Eg5 and TPX2 and Its Role in Branching Microtubule Nucleation

, 2023
Cell division is a critical process for the development of cellular organisms. During cell division, a bipolar structure termed the mitotic spindle must be built from microtubule filaments to align and segregate chromosomes.
Tran, Haley
core  

Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons. [PDF]

, 2012
SummaryMicrotubule nucleation is essential for proper establishment and maintenance of axons and dendrites. Centrosomes, the primary site of nucleation in most cells, lose their function as microtubule organizing centers during neuronal development.
Ori-McKenney, Kassandra M, Jan, Yuh-Nung, Jan, Lily Yeh   +2 more
core   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Axon extension occurs independently of centrosomal microtubule nucleation.

, 2010
Microtubules are polymeric protein structures and components of the cytoskeleton. Their dynamic polymerization is important for diverse cellular functions.
Gomis-Rüth, S., Maghelli, N., Gomis-Ruth, S, Hoogenraad, C., Kapitein, L., Tolic-Norrelykke, I., Wilsch-Brauninger, M, Stiess, M., Bradke, F, Maghelli, N, Bradke, F., Tolic-Norrelykke, IM, Hoogenraad, CC, Stiess, M, Kapitein, Lukas, Gomis-Rueth, S., Wilsch-Bräuninger, M., Frank Bradke, Iva M. Tolić-Nørrelykke, Casper C. Hoogenraad, Nicola Maghelli, Susana Gomis-Rüth, Michaela Wilsch-Bräuninger, Michael Stiess, Lukas C. Kapitein   +24 more
core   +1 more source

Kinetic Control of Condensate Function: How the Formation Dynamics of APBs Influence ALT Cancer Telomere Length Heterogeneity

BioEssays, Volume 48, Issue 10, October 2026.
The dynamics of PML body formation at telomeres in cancer cells using the alternative lengthening of telomeres (ALT) pathway for telomere elongation correlate with different degrees of ALT activity and might contribute to telomere length heterogeneity in ALT cancer cells.
Huaiying Zhang
wiley   +1 more source

Microtubule-based nucleation results in a large sensitivity to cell geometry of the plant cortical array.

PLoS Computational Biology
Many plant cell functions, including cell morphogenesis and anisotropic growth, rely on the self-organisation of cortical microtubules into aligned arrays with the correct orientation.
Marco Saltini, Eva E Deinum
doaj   +1 more source

PDE4DIP/Myomegalin as a Golgi–Centrosome Scaffold in Compartmentalized Signaling, Microtubule Organization, and Disease‐Associated Pathway Remodeling

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT PDE4DIP/Myomegalin was originally identified as a Golgi‐ and centrosome‐associated protein that interacts with phosphodiesterase 4D, but subsequent work has placed it within a broader network of organelle‐associated signaling and cytoskeletal regulation.
Cong Wang, Chunjing Bian, Zhe Wang, Tao Luo   +3 more
wiley   +1 more source