Results 51 to 60 of about 335,784 (179)

CKAP2 ensures chromosomal stability by maintaining the integrity of microtubule nucleation sites. [PDF]

PLoS ONE, 2013
Integrity of the microtubule spindle apparatus and intact cell division checkpoints are essential to ensure the fidelity of distributing chromosomes into daughter cells.
Chanelle M Case, Dan L Sackett, Danny Wangsa, Tatiana Karpova, James G McNally, Thomas Ried, Jordi Camps   +6 more
doaj   +1 more source

Phase Transitioning the Centrosome into a Microtubule Nucleator [PDF]

Biochemistry, 2017
Centrosomes are self-assembling, micron-scale, nonmembrane bound organelles that nucleate microtubules (MTs) and organize the microtubule cytoskeleton of the cell. They orchestrate critical cellular processes such as ciliary-based motility, vesicle trafficking, and cell division.
Michael J. Rale, Rachel S. Kadzik, Sabine Petry   +2 more
openaire   +2 more sources

Cep192 controls the balance of centrosome and non-centrosomal microtubules during interphase. [PDF]

PLoS ONE, 2014
Cep192 is a centrosomal protein that contributes to the formation and function of the mitotic spindle in mammalian cells. Cep192's mitotic activities stem largely from its role in the recruitment to the centrosome of numerous additional proteins such as ...
Brian P O'Rourke, Maria Ana Gomez-Ferreria, Robin H Berk, Alexandra M U Hackl, Matthew P Nicholas, Sean C O'Rourke, Laurence Pelletier, David J Sharp   +7 more
doaj   +1 more source

Microtubule Anchoring: Attaching Dynamic Polymers to Cellular Structures

Frontiers in Cell and Developmental Biology, 2022
Microtubules are dynamic, filamentous polymers composed of α- and β-tubulin. Arrays of microtubules that have a specific polarity and distribution mediate essential processes such as intracellular transport and mitotic chromosome segregation. Microtubule
Chithran Vineethakumari, Jens Lüders
doaj   +1 more source

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

Cell Reports, 2017
Non-centrosomal microtubule bundles play important roles in cellular organization and function. Although many diverse proteins are known that can bundle microtubules, biochemical mechanisms by which cells could locally control the nucleation and ...
Amayra Hernández-Vega, Marcus Braun, Lara Scharrel, Marcus Jahnel, Susanne Wegmann, Bradley T. Hyman, Simon Alberti, Stefan Diez, Anthony A. Hyman   +8 more
doaj   +1 more source

Microtubule nucleation: γ-tubulin and beyond [PDF]

Journal of Cell Science, 2006
Centrosomes and their fungal equivalents, spindle pole bodies (SPBs), are the main microtubule (MT)-organizing centers in eukaryotic cells. Several proteins have been implicated in microtubule formation by centrosomes and SPBs, including microtubule-minus-end-binding proteins and proteins that bind along the length or stabilize the plus ends of ...
Christiane, Wiese, Yixian, Zheng
openaire   +2 more sources

Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation

Science
Microtubules are essential for intracellular organization and chromosome segregation. They are nucleated by the γ-tubulin ring complex (γTuRC). However, isolated vertebrate γTuRC adopts an open conformation that deviates from the microtubule structure ...
Cláudia Brito, Marina Serna, Pablo Guerra, Oscar Llorca, Thomas Surrey   +4 more
semanticscholar   +1 more source

The role of γ-tubulin in centrosomal microtubule organization. [PDF]

PLoS ONE, 2012
As part of a multi-subunit ring complex, γ-tubulin has been shown to promote microtubule nucleation both in vitro and in vivo, and the structural properties of the complex suggest that it also seals the minus ends of the polymers with a conical cap ...
Eileen O'Toole, Garrett Greenan, Karen I Lange, Martin Srayko, Thomas Müller-Reichert   +4 more
doaj   +1 more source

Centrosomal and acentrosomal microtubule nucleation during neuronal development.

Current Opinion in Neurobiology
Neurons rely on the microtubule cytoskeleton to create and maintain their sophisticated cellular architectures. Advances in cryogenic electron microscopy, expansion microscopy, live imaging, and gene editing have enabled novel insights into mechanisms of
Stanislav Vinopal, F. Bradke
semanticscholar   +1 more source

Microtubule oscillations. Role of nucleation and microtubule number concentration.

Journal of Biological Chemistry, 1990
Microtubules are capable of performing synchronized oscillations of assembly and disassembly which has been explained by reaction mechanisms involving tubulin subunits, oligomers, microtubules, and GTP. Here we address the question of how microtubule nucleation or their number concentration affects the oscillations.
Obermann, H., Mandelkow, E. M., Lange, G., Mandelkow, E.   +3 more
openaire   +3 more sources