Results 51 to 60 of about 211,422 (165)
Polyamine sharing between tubulin dimers favours microtubule nucleation and elongation via facilitated diffusion. [PDF]
PLoS Computational Biology, 2009 We suggest for the first time that the action of multivalent cations on microtubule dynamics can result from facilitated diffusion of GTP-tubulin to the microtubule ends.
Alain Mechulam +5 more
doaj +1 more source
Regulatory mechanisms of centrosomal microtubule nucleation
, 2021 The spatio-temporal organization and dynamic behavior of microtubules accurately react to cellular needs during intracellular transport, signal transduction, growth, division, and differentiation.
Klebanovych, Anastasiya
core
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto +5 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas +5 more
wiley +1 more source
Autocatalytic microtubule nucleation determines the size and mass of spindles
, 2017 Regulation of size and growth is a fundamental problem in biology. A prominent example is the formation of the mitotic spindle, where protein concentration gradients around chromosomes are thought to regulate spindle growth by controlling microtubule ...
Benjamin Dalton +3 more
core +1 more source
Author response: Autocatalytic microtubule nucleation determines the size and mass of Xenopus laevis egg extract spindles [PDF]
, 2017 Regulation of size and growth is a fundamental problem in biology. A prominent example is the formation of the mitotic spindle, where protein concentration gradients around chromosomes are thought to regulate spindle growth by controlling microtubule ...
Brugués, J. +11 more
core +1 more source
Protein Glutamylation: From Cytoskeleton to Signaling
Med Research, EarlyView.Tubulin glutamylation, γ‐glutamylation, and nontubulin glutamylation are distinct yet interconnected post‐translational modifications that regulate diverse physiological and pathological processes, including cytoskeletal organization, cell cycle progression, immunity, metabolism, and disease development.
Jiayuan Chen +4 more
wiley +1 more source
Pest Management Science, EarlyView.Using cellular phenotyping and resistance profiling, we show that herbicides across the Herbicide Resistance Action Committee (HRAC) Groups 3 and 23 induce indistinguishable, dose‐dependent microtubule defects. Resistance patterns, rather than cellular phenotypes, reveal distinct sites of action and support reclassifying Group 3 as α‐tubulin binders ...
Katharina Kaprocki +6 more
wiley +1 more source
Smart Molecules, EarlyView.MOFs offer high porosity and tunability for biomedical applications, especially in cancer therapy via ROS generation and targeted delivery. Though toxicity, stability, and scalability remain key clinical challenges. Drug loading in MOFs exceeds 60%–70% with controlled release behavior.
Jagabandhu Bag +6 more
wiley +1 more source
Collective dynamics of actin and microtubule and its crosstalk mediated by FHDC1
Frontiers in Cell and Developmental BiologyThe coordination between actin and microtubule network is crucial, yet this remains a challenging problem to dissect and our understanding of the underlying mechanisms remains limited.
Chee San Tong +16 more
doaj +1 more source