XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions. [PDF]
Mol Biol Cell, 2020 Microtubule nucleation is spatiotemporally regulated in cells by several known molecules, including the template γ-tubulin and the polymerase XMAP215.
King BR +5 more
europepmc +2 more sources
Microtubule Anchoring: Attaching Dynamic Polymers to Cellular Structures
Frontiers in Cell and Developmental Biology, 2022 Microtubules are dynamic, filamentous polymers composed of α- and β-tubulin. Arrays of microtubules that have a specific polarity and distribution mediate essential processes such as intracellular transport and mitotic chromosome segregation. Microtubule
Chithran Vineethakumari, Jens Lüders
doaj +1 more source
Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase
Cell Reports, 2017 Non-centrosomal microtubule bundles play important roles in cellular organization and function. Although many diverse proteins are known that can bundle microtubules, biochemical mechanisms by which cells could locally control the nucleation and ...
Amayra Hernández-Vega +8 more
doaj +1 more source
The role of γ-tubulin in centrosomal microtubule organization. [PDF]
PLoS ONE, 2012 As part of a multi-subunit ring complex, γ-tubulin has been shown to promote microtubule nucleation both in vitro and in vivo, and the structural properties of the complex suggest that it also seals the minus ends of the polymers with a conical cap ...
Eileen O'Toole +4 more
doaj +1 more source
Latrunculin A delays anaphase onset in fission yeast by disrupting an ase1-independent pathway controlling mitotic spindle stability [PDF]
, 2008 It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast.
Meadows, John C., Millar, Jonathan B. A.
core +1 more source
Molecular dissection of mitochondria-microtubule interaction and microtubule nucleation
, 2017 Mitochondria are dynamic bioenergetic organelles and their distributions are tightly coupled with energy demands. Mitochondria also interact with other cellular structures to modulate their functions and regulate their positioning.
Li, Tianpeng, 李天鵬
core +1 more source
CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex [PDF]
, 2010 CDK5RAP2 is a human microcephaly protein that contains a γ-tubulin complex (γ-TuC)–binding domain conserved in Drosophila melanogaster centrosomin and Schizosaccharomyces pombe Mto1p and Pcp1p, which are γ-TuC–tethering proteins.
Yuk-Kwan Choi +9 more
core +1 more source
Cell Reports, 2020 Summary: How γ-tubulin ring complex (γ-TuRC), a master template for microtubule nucleation, is spatially and temporally regulated for the assembly of new microtubule arrays remains unclear.
Tzu-Lun Huang +4 more
doaj +1 more source
The Role of Microtubule-Associated Proteins During Microtubule Nucleation and Organization [PDF]
, 2020 Thesis (Ph.D.)--University of Washington, 2020Successful mitotic division is fundamental to life. During mitosis, the cytoskeletal network is reorganized to form the bipolar spindle: microtubules extend from microtubule-organizing centers to attach to ...
King, Brianna Rose
core
Harnessing Phase Separation for the Development of High‐Performance Hydrogels
Advanced Science, EarlyView.ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao +3 more
wiley +1 more source