Results 31 to 40 of about 335,784 (179)
Endocytosis of Wnt ligands from surrounding epithelial cells positions microtubule nucleation sites at dendrite branch points. [PDF]
PLoS BiologyMicrotubule nucleation is important for microtubule organization in dendrites and for neuronal injury responses. The core nucleation protein, γTubulin (γTub), is localized to dendrite branch points in Drosophila sensory neurons by Wnt receptors and ...
Pankajam Thyagarajan +7 more
doaj +2 more sources
Small GTPase ARL4C Associated with Various Cancers Affects Microtubule Nucleation [PDF]
BiomedicinesBackground/Objectives: The changes in the level of small GTPase ARL4C are associated with the initiation and progression of many different cancers. The content of ARL4C varies greatly between different tissues, and the induction of ARL4C expression leads
Evgeniia Ulas +2 more
doaj +2 more sources
Partial closure of the γ-tubulin ring complex by CDK5RAP2 activates microtubule nucleation
Developmental CellMicrotubule nucleation is templated by the γ-tubulin ring complex (γ-TuRC), but its structure deviates from the geometry of α-/β-tubulin in the microtubule, explaining the complex's poor nucleating activity.
Yixin Xu
exaly +2 more sources
Detection of Microtubule Nucleation Hotspots at the Golgi. [PDF]
Methods Mol Biol, 2020 Cell polarization is important for multiple physiological processes. In motile cells, microtubules (MTs) are organized as a polarized array, which is to a large extent comprised of Golgi-derived MTs (GDMTs), which asymmetrically extend toward the cell front.
Thoppil RJ, Sanders AAWM, Kaverina I.
europepmc +4 more sources
Direct induction of microtubule branching by microtubule nucleation factor SSNA1 [PDF]
Nature Cell Biology, 2018 Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed microtubule seeds or from γ-tubulin recruited to the side ...
Nirakar Basnet +11 more
semanticscholar +5 more sources
Reconstitution of Microtubule Nucleation In Vitro Reveals Novel Roles for Mzt1. [PDF]
Curr Biol, 2019 Summary Microtubule (MT) nucleation depends on the γ-tubulin complex (γ-TuC), in which multiple copies of the heterotetrameric γ-tubulin small complex (γ-TuSC) associate to form a ring-like structure (in metazoans, γ-tubulin ring complex; γ-TuRC) [1, 2 ...
Leong SL +7 more
europepmc +2 more sources
Insight into microtubule nucleation from tubulin-capping proteins
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Microtubules are involved in many key functions of eukaryotic cells, including cell division, intracellular transport, and cell shape. They are hollow tubes made of parallel filaments, themselves formed by the self-assembly of αβ-tubulin ...
Valerie Campanacci +2 more
exaly +2 more sources
The XMAP215 Ortholog Alp14 Promotes Microtubule Nucleation in Fission Yeast
Current Biology, 2018 SUMMARY The organization and number of microtubules (MTs) in a cell depends on the proper regulation of MT nucleation. Currently, the mechanism of nucleation is the most poorly understood aspect of MT dynamics.
Ignacio Flor-Parra, Fred Chang
exaly +2 more sources
Microtubule nucleation and organization without centrosomes.
Current Opinion in Plant Biology, 2018 Centrosomes play various critical roles in animal cells such as microtubule nucleation and stabilization, mitotic spindle morphogenesis, and spindle orientation. Land plants have lost centrosomes and yet must execute many of these functions.
Peishan Yi, Gohta Goshima
semanticscholar +3 more sources
eLife, 2018 Stu2/XMAP215/ZYG-9/Dis1/Alp14/Msps/ch-TOG family members in association with with γ-tubulin complexes nucleate microtubules, but we know little about the interplay of these nucleation factors. Here, we show that the budding yeast Stu2 in complex with the
Judith Gunzelmann +6 more
doaj +2 more sources