Results 21 to 30 of about 211,422 (165)
The actin regulator profilin 1 is functionally associated with the mammalian centrosome
Life Science Alliance, 2021 The actin regulator profilin 1 recently shown to control microtubule elongation at the cell periphery is found to interact with the γ-tubulin ring complex and tune centrosomal microtubule nucleation.
Michaela Nejedlá +6 more
doaj +1 more source
Regulation of cell migration by dynamic microtubules [PDF]
, 2011 Microtubules define the architecture and internal organization of cells by positioning organelles and activities, as well as by supporting cell shape and mechanics. One of the major functions of microtubules is the control of polarized cell motility.
Irina Kaverina +3 more
core +1 more source
Integrated model of the vertebrate augmin complex
Nature Communications, 2023 Accurate segregation of chromosomes is required to maintain genome integrity during cell division. This feat is accomplished by the microtubule-based spindle.
Sophie M. Travis +8 more
doaj +1 more source
Nuclei of Non-Muscle Cells Bind Centrosome Proteins upon Fusion with Differentiating Myoblasts [PDF]
, 2009 Background: In differentiating myoblasts, the microtubule network is reorganized from a centrosome-bound, radial array into parallel fibres, aligned along the long axis of the cell.
Espigat-Georger Aude +11 more
core +2 more sources
eLife, 2018 Regulation of size and growth is a fundamental problem in biology. A prominent example is the formation of the mitotic spindle, where protein concentration gradients around chromosomes are thought to regulate spindle growth by controlling microtubule ...
Franziska Decker +3 more
doaj +1 more source
Cells, 2019 The antigen-mediated activation of mast cells initiates signaling events leading to their degranulation, to the release of inflammatory mediators, and to the synthesis of cytokines and chemokines.
Anastasiya Klebanovych +8 more
doaj +1 more source
CKAP2 ensures chromosomal stability by maintaining the integrity of microtubule nucleation sites. [PDF]
PLoS ONE, 2013 Integrity of the microtubule spindle apparatus and intact cell division checkpoints are essential to ensure the fidelity of distributing chromosomes into daughter cells.
Chanelle M Case +6 more
doaj +1 more source
Cells, 2021 Higher plants represent a large group of eukaryotes where centrosomes are absent. The functions of γ-tubulin small complexes (γ-TuSCs) and γ-tubulin ring complexes (γ-TuRCs) in metazoans and fungi in microtubule nucleation are well established and the ...
Jana Chumová +4 more
doaj +1 more source
Structure and function of microtubule nucleation proteins [PDF]
, 2002 Microtubules are filamentous, non-covalent polymers present in all eukaryotic cells. They have essential roles in cell division, intracellular transport, cell motility and cell organisation.
Le Cornu, James
core +1 more source
Cep192 controls the balance of centrosome and non-centrosomal microtubules during interphase. [PDF]
PLoS ONE, 2014 Cep192 is a centrosomal protein that contributes to the formation and function of the mitotic spindle in mammalian cells. Cep192's mitotic activities stem largely from its role in the recruitment to the centrosome of numerous additional proteins such as ...
Brian P O'Rourke +7 more
doaj +1 more source