Regulation of microtubule nucleation in glioblastoma cells by ARF GTPase-activating proteins GIT1 and GIT2 and protein kinase C [PDF]
Cancer Cell InternationalBackground G protein-coupled receptor kinase-interacting proteins (GITs) function as GTPase-activating proteins (GAPs) for small GTPases of the ADP-ribosylation factor (Arf) family.
Vadym Sulimenko +6 more
doaj +2 more sources
Regulation of microtubule nucleation in mouse bone marrow-derived mast cells by ARF GTPase-activating protein GIT2 [PDF]
Frontiers in ImmunologyAggregation of high-affinity IgE receptors (FcϵRIs) on granulated mast cells triggers signaling pathways leading to a calcium response and release of inflammatory mediators from secretory granules.
Vadym Sulimenko +7 more
doaj +2 more sources
Spindle Scaling Is Governed by Cell Boundary Regulation of Microtubule Nucleation
Current Biology, 2020 Cellular organelles such as the mitotic spindle adjust their size to the dimensions of the cell. It is widely understood that spindle scaling is governed by regulation of microtubule polymerization. Here we use quantitative microscopy in living zebrafish
Franziska Decker +2 more
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Microtubule nucleation and organization in dendrites [PDF]
Cell Cycle, 2016 Dendrite branching is an essential process for building complex nervous systems. It determines the number, distribution and integration of inputs into a neuron, and is regulated to create the diverse dendrite arbor branching patterns characteristic of different neuron types.
Caroline Delandre, Adrian Moore
exaly +3 more sources
XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions. [PDF]
Mol Biol Cell, 2020 Microtubule nucleation is spatiotemporally regulated in cells by several molecules, including the template γ-tubulin and the polymerase XMAP215. Recently, XMAP215 and the γ-tubulin ring complex were reported to function synergistically, and this synergy ...
King BR +5 more
europepmc +2 more sources
eLife, 2018 Regulation of size and growth is a fundamental problem in biology. A prominent example is the formation of the mitotic spindle, where protein concentration gradients around chromosomes are thought to regulate spindle growth by controlling microtubule ...
Franziska Decker +3 more
doaj +2 more sources
Control of nucleation in microtubule self-assembly [PDF]
FEBS Letters, 1986 The inhibition of the rate and amplitude of assembly of microtubule protein at low GTP concentration is shown by measurement of microtubule length distributions to be due to the suppression of microtubule nucleation. This inhibitory effect is enhanced by GDP added before assembly, but can be overcome by a number of molecules such as pyrophosphate or ...
P M Bayley
exaly +3 more sources
Structural basis of human γTuRC closure during CM1-activated microtubule nucleation [PDF]
Nature CommunicationsMicrotubule nucleation by the γ-tubulin ring complex (γTuRC) is spatiotemporally regulated and in higher eukaryotes is thought to involve a transition from an inactive open to an active closed conformation that matches the microtubule geometry.
Marina Serna +9 more
doaj +2 more sources
The ciliopathy protein CCDC66 controls mitotic progression and cytokinesis by promoting microtubule nucleation and organization. [PDF]
PLoS Biology, 2022 Precise spatiotemporal control of microtubule nucleation and organization is critical for faithful segregation of cytoplasmic and genetic material during cell division and signaling via the primary cilium in quiescent cells.
Umut Batman +2 more
doaj +2 more sources
Endosomal Wnt signaling proteins control microtubule nucleation in dendrites. [PDF]
PLoS Biol, 2020 Dendrite microtubules are polarized with minus-end-out orientation in Drosophila neurons. Nucleation sites concentrate at dendrite branch points, but how they localize is not known.
Weiner AT +18 more
europepmc +2 more sources