Results 61 to 70 of about 211,422 (165)
New Journal of Physics, 2018 Spindles are self-organized microtubule-based structures that segregate chromosomes during cell division. The mass of the spindle is controlled by the balance between microtubule turnover and nucleation. The mechanisms that control the spatial regulation
Bryan Kaye +5 more
doaj +1 more source
Frontiers in Microbiology, 2020 The conserved Dis1/Stu2/XMAP215 microtubule association proteins (MAPs) family plays an important role in microtubule dynamics, nucleation, and kinetochore-microtubule attachments.
Yuanye Zhu +7 more
doaj +1 more source
Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma
Allergy, EarlyView.This study investigates the effect of mepolizumab on the proteomic and transcriptomic profile of blood eosinophils in SEA patients. Mepolizumab reduces the migratory capacity and effector‐related molecular signatures of circulating eosinophils in SEA patients.
Pablo Miguéns‐Suárez +14 more
wiley +1 more source
A molecular analysis of the microtubule associated protein MAP65-1 [PDF]
, 2006 Microtubules (MTs) play important roles in various cellular processes including cell division, organelle movement and the determination of cellular morphology. The dynamics and organization of microtubules are regulated by microtubule associated proteins
Hsin Yu, Chang
core
The Place of Noncentrosomal Microtubule Nucleation
, 2013 The initial stages of noncentrosomal microtubule nucleation revealed by an endogenous GFP–α-tubulin fusion (left) and phase contrast (right). Following the corresponding videos, it is possible to unmistakably tell the chromosomes (arrows) apart form the ...
Cayetano Gonzalez (10) +3 more
core +1 more source
γ-TuRC asymmetry induces local protofilament mismatch at the RanGTP-stimulated microtubule minus end
The EMBO JournalThe γ-tubulin ring complex (γ-TuRC) is a structural template for de novo microtubule assembly from α/β-tubulin units. The isolated vertebrate γ-TuRC assumes an asymmetric, open structure deviating from microtubule geometry, suggesting that γ-TuRC closure
Bram JA Vermeulen +10 more
doaj +1 more source
Myomegalin is necessary for the formation of centrosomal and Golgi-derived microtubules
Biology Open, 2012 Summary The generation of cellular microtubules is initiated at specific sites such as the centrosome and the Golgi apparatus that contain nucleation complexes rich in γ-tubulin.
Régine Roubin +6 more
doaj +1 more source
Sperm Head–Tail Coupling Apparatus Diversity and Common Themes Among Species
Andrology, EarlyView.ABSTRACT Background A stable connection between the sperm head (containing the nucleus and acrosome) and tail (containing the axoneme, mitochondrial sheath, and periaxonemal structures) is critical for fertility. This connection is mediated by a series of nuclear, cytoplasmic, and centriole components that make up the head–tail coupling apparatus (HTCA)
Danielle B. Buglak +2 more
wiley +1 more source
Microtubules are organized independently of the centrosome in
Neural Development, 2011 Background The best-studied arrangement of microtubules is that organized by the centrosome, a cloud of microtubule nucleating and anchoring proteins is clustered around centrioles.
Nguyen Michelle M +2 more
doaj +1 more source
Monte Carlo simulations of microtubule arrays: The critical roles of rescue transitions, the cell boundary, and tubulin concentration in shaping microtubule distributions. [PDF]
PLoS ONE, 2018 Microtubules are dynamic polymers required for a number of processes, including chromosome movement in mitosis. While regulators of microtubule dynamics have been well characterized, we lack a convenient way to predict how the measured dynamic parameters
Lynne Cassimeris +2 more
doaj +1 more source