Results 91 to 100 of about 211,422 (165)

Microtubule branch.png

, 2018
Snapshots of microtubule branching during nucleation observed by cryo ...
Nirakar Basnet (5508104), Alvaro H. Crevenna (4042724), Thomas Schlichthaerle (4450609), Giovanni Cardone (389999), Hana Nedozralova (5517671), Michael Taschner (5517656), Carsten Janke (5517662), Satish Bodakuntla (5517674), Ralf Jungmann (1478587), Maria M. Magiera (5517665), Christian Biertümpfel (5517659), Naoko Mizuno (5517668)   +11 more
core   +1 more source

Detection and Analysis of Microtubule Nucleator γ-Tubulin Ring Complex

, 2023
Golgi-derived microtubules constitute an asymmetrical microtubule network that drives polarized transport of vesicles to support cell polarization and directional migration.
Qi, Robert Z., Au, Franco K.C., Le, Khoi T.D.   +2 more
core   +1 more source

Physical basis of large microtubule aster growth

eLife, 2016
Microtubule asters - radial arrays of microtubules organized by centrosomes - play a fundamental role in the spatial coordination of animal cells. The standard model of aster growth assumes a fixed number of microtubules originating from the centrosomes.
Keisuke Ishihara, Kirill S Korolev, Timothy J Mitchison   +2 more
doaj   +1 more source

Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging

Aging Cell, Volume 25, Issue 10, October 2026.
We reported a novel peptide therapy showing that elamipretide restores the quality of aged oocytes for fertility by coordinately boosting oocyte nuclear and cytoplasmic maturation via activation of the VEGF signaling pathway. ABSTRACT Aging represents a major contributor to the deterioration of female fertility, with oocyte quality being the central ...
Hao‐Lin Zhang, Yue Wang, Caizhu Wang, Xin Guo, Huanhua Chen, Yu‐Xuan Hou, Xuan Wu, Zi‐Jian Wu, Wen‐Lin Pan, Rui‐Jie Ma, Ping‐Shuang Lu, Jinhui Shu, Shao‐Chen Sun   +12 more
wiley   +1 more source

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus-ends and is involved in establishing parallel arrays of microtubule bundles in highly polarised epithelial cells [PDF]

, 2002
Loss of full-length adenomatous polyposis coli (APC) protein correlates with the development of colon cancers in familial and sporadic cases. In addition to its role in regulating ß-catenin levels in the Wnt signaling pathway, the APC protein is ...
John B. Mackie, Mackie, JB, Nathke, Inke S.; id_orcid, Prescott, AR, Nathke, IS, Mogensen, MM, Mette M. Mogensen, Prescott, Alan R.; id_orcid, Mackie, John B., Tucker, John B., Inke S. Näthke, Näthke, Inke S., John B. Tucker, Mogensen, Mette M., Prescott, Alan R., Alan R. Prescott, Tucker, John Barry   +16 more
core   +1 more source

Branching Microtubule Nucleation in Xenopus Egg Extracts Mediated by Augmin and TPX2

, 2013
SummaryThe microtubules that comprise mitotic spindles in animal cells are nucleated at centrosomes and by spindle assembly factors that are activated in the vicinity of chromatin. Indirect evidence has suggested that microtubules also might be nucleated
Vale, Ronald D, Groen, Aaron C, Mitchison, Timothy J, Petry, Sabine, Ishihara, Keisuke   +4 more
core   +1 more source

The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules

Nature Communications, 2017
Microtubule organization requires γ-tubulin ring complexes (γTuRCs), but the mechanisms that control γTuRC-mediated microtubule nucleation are unclear.
Yuehong Shen, Pengfei Liu, Taolue Jiang, Yu Hu, Franco K. C. Au, Robert Z. Qi   +5 more
doaj   +1 more source

Mto2 multisite phosphorylation inactivates non-spindle microtubule nucleation complexes during mitosis [PDF]

, 2015
Microtubule nucleation is highly regulated during the eukaryotic cell cycle, but the underlying molecular mechanisms are largely unknown. During mitosis in fission yeast Schizosaccharomyces pombe, cytoplasmic microtubule nucleation ceases simultaneously ...
Groocock, Lynda M., De Lima Alves, Flavia, Borek, Weronika E., Sawin, Kenneth E., Rappsilber, Juri, Samejima, Itaru, Zou, Juan   +6 more
core   +1 more source

CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation.

PLoS Biology
The densely packed centromeric heterochromatin at minor and major satellites is comprised of H3K9me2/3 histones, the heterochromatin protein HP1α, and histone variants.
Gokul Gopinathan, Qian Xu, Xianghong Luan, Thomas G H Diekwisch   +3 more
doaj   +1 more source

Microtubule nucleation for spindle assembly: one molecule at a time. [PDF]

Trends Biochem Sci, 2023
Kraus J, Alfaro-Aco R, Gouveia B, Petry S.   +3 more
europepmc   +1 more source