Results 131 to 140 of about 34,353 (227)

The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules

Nature Communications, 2017
Microtubule organization requires γ-tubulin ring complexes (γTuRCs), but the mechanisms that control γTuRC-mediated microtubule nucleation are unclear.
Yuehong Shen, Pengfei Liu, Taolue Jiang, Yu Hu, Franco K. C. Au, Robert Z. Qi   +5 more
doaj   +1 more source

Condensate functionalization with microtubule motors directs their nucleation in space and allows manipulating RNA localization

, 2023
Audrey Cochard, Adham Safieddine, Pauline Combe, Marie‐Noëlle Benassy, Dominique Weil, Zoher Gueroui   +5 more
openalex   +2 more sources

In vitro reactivation of spindle elongation in fission yeast nuc2 mutant cells. [PDF]

, 1990
To investigate the mechanisms of spindle elongation and chromosome separation in the fission yeast Schizosaccharomyces pombe, we have developed an in vitro assay using a temperature-sensitive mutant strain, nuc2.
Cande, WZ, Hirano, T, Masuda, H, Yanagida, M   +3 more
core  

CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation.

PLoS Biology
The densely packed centromeric heterochromatin at minor and major satellites is comprised of H3K9me2/3 histones, the heterochromatin protein HP1α, and histone variants.
Gokul Gopinathan, Qian Xu, Xianghong Luan, Thomas G H Diekwisch   +3 more
doaj   +1 more source

Microtubule nucleation for spindle assembly: one molecule at a time. [PDF]

Trends Biochem Sci, 2023
Kraus J, Alfaro-Aco R, Gouveia B, Petry S.   +3 more
europepmc   +1 more source

CM1-driven assembly and activation of Yeast γ-Tubulin Small Complex underlies microtubule nucleation [PDF]

, 2020
Axel F. Brilot, Andrew S. Lyon, Alex Zelter, Shruthi Viswanath, Alison M. Maxwell, Michael J. MacCoss, Eric G. Muller, Andrej Săli, Trisha N. Davis, David A. Agard   +9 more
openalex   +1 more source

Abl2 repairs microtubules and phase separates with tubulin to promote microtubule nucleation. [PDF]

Curr Biol, 2023
Duan D, Lyu W, Chai P, Ma S, Wu K, Wu C, Xiong Y, Sestan N, Zhang K, Koleske AJ.   +9 more
europepmc   +1 more source

Conserved function of the HAUS6 calponin homology domain in anchoring augmin for microtubule branching

Nature Communications
Branching microtubule nucleation is a key mechanism for mitotic and meiotic spindle assembly and requires the hetero-octameric augmin complex. Augmin recruits the major microtubule nucleator, the γ-tubulin ring complex, to pre-existing microtubules to ...
Martin Würtz, Giulia Tonon, Bram J. A. Vermeulen, Maja Zezlina, Qi Gao, Annett Neuner, Angelika Seidl, Melanie König, Maximilian Harkenthal, Sebastian Eustermann, Sylvia Erhardt, Fabio Lolicato, Elmar Schiebel, Stefan Pfeffer   +13 more
doaj   +1 more source

Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes. [PDF]

J Cell Biol, 2023
Zhu Z, Becam I, Tovey CA, Elfarkouchi A, Yen EC, Bernard F, Guichet A, Conduit PT.   +7 more
europepmc   +1 more source

Insights into centriole geometry revealed by cryotomography of doublet and triplet centrioles. [PDF]

, 2018
Centrioles are cylindrical assemblies comprised of 9 singlet, doublet, or triplet microtubules, essential for the formation of motile and sensory cilia.
Agard, David A, Greenan, Garrett A, Keszthelyi, Bettina, Vale, Ronald D   +3 more
core   +1 more source