Results 21 to 30 of about 34,353 (227)
Endosomal Wnt signaling proteins control microtubule nucleation in dendrites. [PDF]
PLoS Biology, 2020 Dendrite microtubules are polarized with minus-end-out orientation in Drosophila neurons. Nucleation sites concentrate at dendrite branch points, but how they localize is not known.
Alexis T Weiner +18 more
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Quantitative Plant BiologyThe development of the water transporting xylem tissue in plants involves an intricate interplay of Rho-of-Plants (ROP) proteins and cortical microtubules to generate highly functional secondary cell wall patterns, such as the ringed or spiral patterns ...
Bas Jacobs +4 more
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Microtubule nucleation by γ-tubulin complexes [PDF]
Nature Reviews Molecular Cell Biology, 2011 Microtubule nucleation is regulated by the γ-tubulin ring complex (γTuRC) and related γ-tubulin complexes, providing spatial and temporal control over the initiation of microtubule growth. Recent structural work has shed light on the mechanism of γTuRC-based microtubule nucleation, confirming the long-standing hypothesis that the γTuRC functions as a ...
Justin M. Kollman +3 more
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Microtubule nucleation without a ring? [PDF]
J Cell Biol, 2021 The native γ-tubulin ring complex is an asymmetric, imperfect template for microtubule nucleation. Wieczorek et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202009146) and Zimmermann et al. (2020. Sci. Adv.https://doi.org/10.1126/sciadv.abe0894) have reconstituted a recombinant complex that allows study of structure–function relationships and ...
Merdes A.
europepmc +4 more sources
Control of nucleation in microtubule self‐assembly [PDF]
FEBS Letters, 1986 The inhibition of the rate and amplitude of assembly of microtubule protein at low GTP concentration is shown by measurement of microtubule length distributions to be due to the suppression of microtubule nucleation. This inhibitory effect is enhanced by GDP added before assembly, but can be overcome by a number of molecules such as pyrophosphate or ...
Peter M. Bayley +2 more
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Detection of Microtubule Nucleation Hotspots at the Golgi. [PDF]
Methods Mol Biol, 2020 Thoppil RJ, Sanders AAWM, Kaverina I.
europepmc +3 more sources
Insight into microtubule nucleation from tubulin-capping proteins. [PDF]
Proc Natl Acad Sci U S A, 2019 Campanacci V +12 more
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Cytoskeleton: Microtubule nucleation takes shape [PDF]
Current Biology, 1996 The centrosomal protein gamma-tubulin is part of a ring-shaped complex that can induce microtubule polymerization. This complex may explain how the centrosome nucleates microtubule polymerization, and thereby organizes the microtubule cytoskeleton.
Murphy, Steven M, Stearns, Tim
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Cell edges accumulate gamma tubulin complex components and nucleate microtubules following cytokinesis in Arabidopsis thaliana. [PDF]
PLoS ONE, 2011 Microtubules emanate from distinct organizing centers in fungal and animal cells. In plant cells, by contrast, microtubules initiate from dispersed sites in the cell cortex, where they then self-organize into parallel arrays.
Chris Ambrose, Geoffrey O Wasteneys
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Monomeric γ-Tubulin Nucleates Microtubules [PDF]
Journal of Biological Chemistry, 2000 gamma-Tubulin is required for nucleation and polarized organization of microtubules in vivo. The mechanism of microtubule nucleation by gamma-tubulin and the role of associated proteins is not understood. Here we show that in vitro translated monomeric gamma-tubulin nucleates microtubules by lowering the size of the nucleus from seven to three tubulin ...
R, Leguy +3 more
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