Results 31 to 40 of about 34,353 (227)
Integrated model of the vertebrate augmin complex
Nature Communications, 2023 Accurate segregation of chromosomes is required to maintain genome integrity during cell division. This feat is accomplished by the microtubule-based spindle.
Sophie M. Travis +8 more
doaj +1 more source
Anomalous relaxation kinetics of biological lattice-ligand binding models [PDF]
, 2002 We discuss theoretical models for the cooperative binding dynamics of ligands to substrates, such as dimeric motor proteins to microtubules or more extended macromolecules like tropomyosin to actin filaments.
Anon +6 more
core +3 more sources
Cells, 2021 Higher plants represent a large group of eukaryotes where centrosomes are absent. The functions of γ-tubulin small complexes (γ-TuSCs) and γ-tubulin ring complexes (γ-TuRCs) in metazoans and fungi in microtubule nucleation are well established and the ...
Jana Chumová +4 more
doaj +1 more source
eLife, 2018 Regulation of size and growth is a fundamental problem in biology. A prominent example is the formation of the mitotic spindle, where protein concentration gradients around chromosomes are thought to regulate spindle growth by controlling microtubule ...
Franziska Decker +3 more
doaj +1 more source
CKAP2 ensures chromosomal stability by maintaining the integrity of microtubule nucleation sites. [PDF]
PLoS ONE, 2013 Integrity of the microtubule spindle apparatus and intact cell division checkpoints are essential to ensure the fidelity of distributing chromosomes into daughter cells.
Chanelle M Case +6 more
doaj +1 more source
In vitro reconstitution of branching microtubule nucleation. [PDF]
Elife, 2020 Eukaryotic cell division requires the mitotic spindle, a microtubule (MT)-based structure which accurately aligns and segregates duplicated chromosomes. The dynamics of spindle formation are determined primarily by correctly localising the MT nucleator, γ-Tubulin Ring Complex (γ-TuRC), within the cell. A conserved MT-associated protein complex, Augmin,
Tariq A +4 more
europepmc +5 more sources
Structural insight into TPX2-stimulated microtubule assembly [PDF]
, 2017 During mitosis and meiosis, microtubule (MT) assembly is locally upregulated by the chromatin-dependent Ran-GTP pathway. One of its key targets is the MT-associated spindle assembly factor TPX2.
Nogales, Eva +3 more
core +2 more sources
Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning. [PDF]
, 2015 Casein kinase 1δ (CK1δ) family members associate with microtubule-organizing centers (MTOCs) from yeast to humans, but their mitotic roles and targets have yet to be identified.
Agard, David A +10 more
core +1 more source
Microtubule nucleation: γ-tubulin and beyond [PDF]
Journal of Cell Science, 2006 Centrosomes and their fungal equivalents, spindle pole bodies (SPBs), are the main microtubule (MT)-organizing centers in eukaryotic cells. Several proteins have been implicated in microtubule formation by centrosomes and SPBs, including microtubule-minus-end-binding proteins and proteins that bind along the length or stabilize the plus ends of ...
Christiane, Wiese, Yixian, Zheng
openaire +2 more sources
Cells, 2019 The antigen-mediated activation of mast cells initiates signaling events leading to their degranulation, to the release of inflammatory mediators, and to the synthesis of cytokines and chemokines.
Anastasiya Klebanovych +8 more
doaj +1 more source