Results 41 to 50 of about 34,353 (227)

Mechanism of how augmin directly targets the γ-tubulin ring complex to microtubules [PDF]

, 2018
Microtubules (MTs) must be generated from precise locations to form the structural frameworks required for cell shape and function. MTs are nucleated by the γ-tubulin ring complex (γ-TuRC), but it remains unclear how γ-TuRC gets to the right location ...
Aitken, Akanksha Thawani, Alfaro-Aco, Brinkley, Chen, Drozdetskiy, Fong, Goshima, Goshima, Gruss, Hannak, Haren, Ho, Hsia, Jae-Geun Song, Kimanius, King, Kollman, Lander, Lawo, Lüders, Lüders, Matthew R. King, Mindell, Moritz, Mullins, Nilsson, Petry, Rachel S. Kadzik, Reck-Peterson, Rivero, Robinson, Rui Zhang, Sabine Petry, Suloway, Thawani, Uehara, Wu, Zheng   +38 more
core   +2 more sources

Microtubule Nucleation from Stable Tubulin Oligomers [PDF]

Journal of Biological Chemistry, 2002
Microtubule assembly from purified tubulin preparations involves both microtubule nucleation and elongation. Whereas elongation is well documented, microtubule nucleation remains poorly understood because of difficulties in isolating molecular intermediates between tubulin dimers and microtubules.
Nicolas, Caudron, Isabelle, Arnal, Eric, Buhler, Didier, Job, Odile, Valiron   +4 more
openaire   +2 more sources

A role for Gle1, a regulator of DEAD-box RNA helicases, at centrosomes and basal bodies. [PDF]

, 2017
Control of organellar assembly and function is critical to eukaryotic homeostasis and survival. Gle1 is a highly conserved regulator of RNA-dependent DEAD-box ATPase proteins, with critical roles in both mRNA export and translation.
Akef, Abdalla, Jao, Li-En, Wente, Susan R   +2 more
core   +1 more source

Cep192 controls the balance of centrosome and non-centrosomal microtubules during interphase. [PDF]

PLoS ONE, 2014
Cep192 is a centrosomal protein that contributes to the formation and function of the mitotic spindle in mammalian cells. Cep192's mitotic activities stem largely from its role in the recruitment to the centrosome of numerous additional proteins such as ...
Brian P O'Rourke, Maria Ana Gomez-Ferreria, Robin H Berk, Alexandra M U Hackl, Matthew P Nicholas, Sean C O'Rourke, Laurence Pelletier, David J Sharp   +7 more
doaj   +1 more source

Microtubule Anchoring: Attaching Dynamic Polymers to Cellular Structures

Frontiers in Cell and Developmental Biology, 2022
Microtubules are dynamic, filamentous polymers composed of α- and β-tubulin. Arrays of microtubules that have a specific polarity and distribution mediate essential processes such as intracellular transport and mitotic chromosome segregation. Microtubule
Chithran Vineethakumari, Jens Lüders
doaj   +1 more source

Modeling oscillatory Microtubule--Polymerization [PDF]

, 2002
Polymerization of microtubules is ubiquitous in biological cells and under certain conditions it becomes oscillatory in time. Here simple reaction models are analyzed that capture such oscillations as well as the length distribution of microtubules.
A. Desai, A. Hyman, A. Marx, A. Suzuki, A.C. Newell, A.L. Hitt, B. Houchmandzadeh, C.M. Coppin, D. Sept, D.K. Fygenson, E. Jobs, E. Mandelkow, E.-M. Mandelkow, E.M. Mandelkow, F. Pirolet, F.J. Nedelec, G. Lange, G.J. Vroege, H. Flyvbjerg, H. Oberman, I. Aranson, J. Käs, J. Tabony, J. Tabony, J. Tabony, J. Tabony, L. Onsager, M. Dogterom, M.C. Cross, M.F. Carlier, N. Caudron, O. Valiron, R. Furukawa, R. Melki, R. Wade, T. Surrey, T.J. Mitchison, T.J. Mitchison, W. Schöpf, Y. Chen   +39 more
core   +2 more sources

Microtubule nucleation and organization in dendrites [PDF]

Cell Cycle, 2016
Dendrite branching is an essential process for building complex nervous systems. It determines the number, distribution and integration of inputs into a neuron, and is regulated to create the diverse dendrite arbor branching patterns characteristic of different neuron types.
Caroline, Delandre, Reiko, Amikura, Adrian W, Moore   +2 more
openaire   +2 more sources

Tubulins in C. elegans [PDF]

, 2018
The C. elegans tubulin family is composed of nine α-, six β-, and one γ-tubulin. Tubulins are highly conserved, functioning as α-β heterodimers that assemble into microtubules.
Hurd, Daryl D.
core   +2 more sources

Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase

Cell Reports, 2017
Non-centrosomal microtubule bundles play important roles in cellular organization and function. Although many diverse proteins are known that can bundle microtubules, biochemical mechanisms by which cells could locally control the nucleation and ...
Amayra Hernández-Vega, Marcus Braun, Lara Scharrel, Marcus Jahnel, Susanne Wegmann, Bradley T. Hyman, Simon Alberti, Stefan Diez, Anthony A. Hyman   +8 more
doaj   +1 more source

Influence of M-phase chromatin on the anisotropy of microtubule asters [PDF]

, 1996
In many eukaryotic cells going through M-phase, a bipolar spindle is formed by microtubules nucleated from centrosomes. These microtubules, in addition to being "captured" by kinetochores, may be stabilized by chromatin in two different ways: short-range
Dogterom, M., Félix, M. A., Guet, C. C., Leibler, S.   +3 more
core   +2 more sources