Results 51 to 60 of about 34,353 (227)

Nucleation and Dynamics of Golgi-derived Microtubules [PDF]

Frontiers in Neuroscience, 2015
Integrity of the Golgi apparatus requires the microtubule (MT) network. A subset of MTs originates at the Golgi itself, which in this case functions as a MT-organizing center (MTOC). Golgi-derived MTs serve important roles in post-Golgi trafficking, maintenance of Golgi integrity, cell polarity and motility, as well as cell type-specific functions ...
Sanders, Anna A. W. M., Kaverina, Irina
openaire   +3 more sources

The role of γ-tubulin in centrosomal microtubule organization. [PDF]

PLoS ONE, 2012
As part of a multi-subunit ring complex, γ-tubulin has been shown to promote microtubule nucleation both in vitro and in vivo, and the structural properties of the complex suggest that it also seals the minus ends of the polymers with a conical cap ...
Eileen O'Toole, Garrett Greenan, Karen I Lange, Martin Srayko, Thomas Müller-Reichert   +4 more
doaj   +1 more source

Congenital microcephaly [PDF]

, 2014
The underlying etiologies of genetic congenital microcephaly are complex and multifactorial. Recently, with the exponential growth in the identification and characterization of novel genetic causes of congenital microcephaly, there has been a ...
Agha, Ahmad, Arai, Banin, Bettencourt-Dias, Bicknell, Bicknell, Bolanos-Garcia, Bond, Bongers, Buchman, Caldecott, Caldecott, Capo-Chichi, Carney, Casey, Cimprich, Cizmecioglu, Croteau, Dehay, Dehay, Deriano, Domchek, Fish, Gatz, Gellert, Genin, Gilmore, Gineau, Gorlin, Griffith, Gruber, Guernsey, Han, Hanks, Heldin, Hemerly, Herzog, Heyer, Hickson, Hinchcliffe, Hughes, Issa, Jaglin, Jamieson, Kang, Kee, Kerzendorfer, Kim, Kiyomitsu, Kiyomitsu, Koch, Kumagai, Kuo, Lancaster, Lavin, Lee, Lee, Lee, Lobrich, Loveday, Loveday, Mahmood, Maréchal, Matsumoto, Matsuoka, Matsuura, Meindl, Mimitou, Mirzaa, Miyoshi, Miyoshi, Moldovan, Morris-Rosendahl, Moshous, Moynahan, Murga, Murray, Musacchio, Mühlhans, Noguchi, Novorol, O'Driscoll, O'Driscoll, O'Driscoll, O'Driscoll, O'Driscoll, O'Driscoll, Ogi, Orii, Pilaz, Poirier, Ponting, Qvist, Rakic, Rauch, Riballo, Romaniello, Roos, Rudner, Schneider, Shah, Shaheen, Shaheen, Shamseldin, Shen, Shiloh, Sir, Sirbu, Sokka, Spalding, Spassky, Stewart, Stiff, Stokes, Symington, Tan, Thornton, van der Burg, van der Lelij, Varon, Verloes, Walczak, Waltes, Weedon, Weinfeld, Woodbine, Woods, Wu, Zimmerman   +129 more
core   +1 more source

Augmin Triggers Microtubule-Dependent Microtubule Nucleation in Interphase Plant Cells [PDF]

Current Biology, 2014
Microtubule (MT)-dependent MT nucleation by γ-tubulin is required for interphase plant cells to establish a highly dynamic cortical MT network underneath the plasma membrane, which influences the deposition of cell wall materials and consequently governs patterns of directional cell expansion.
Liu, Ting, Tian, Juan, Wang, Guangda, Yu, Yanjun, Wang, Chaofeng, Ma, Yinping, Zhang, Xiaxia, Xia, Guixian, Liu, Bo, Kong, Zhaosheng   +9 more
openaire   +4 more sources

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. [PDF]

, 2017
As microtubule-organizing centers of animal cells, centrosomes guide the formation of the bipolar spindle that segregates chromosomes during mitosis.
Antkowiak, Mark, Brust-Mascher, Ingrid, Castro, Noemi M, Cheung, Lee, Christensen, Lana N, Huang, Bo, Jao, Li-En, Jiang, Xueer, Mahe, Karan, Ou, Tingyoung, Sepulveda, Guadalupe, Yoon, Daniel   +11 more
core   +2 more sources

Direct induction of microtubule branching by microtubule nucleation factor SSNA1 [PDF]

Nature Cell Biology, 2018
Microtubules are central elements of the eukaryotic cytoskeleton that often function as part of branched networks. Current models for branching include nucleation of new microtubules from severed microtubule seeds or from γ-tubulin recruited to the side of a pre-existing microtubule.
Nirakar Basnet, Hana Nedozralova, Alvaro H. Crevenna, Satish Bodakuntla, Thomas Schlichthaerle, Michael Taschner, Giovanni Cardone, Carsten Janke, Ralf Jungmann, Maria M. Magiera, Christian Biertümpfel, Naoko Mizuno   +11 more
openaire   +4 more sources

Augmin-dependent microtubule nucleation at microtubule walls in the spindle [PDF]

Journal of Cell Biology, 2013
The formation of a functional spindle requires microtubule (MT) nucleation from within the spindle, which depends on augmin. How augmin contributes to MT formation and organization is not known because augmin-dependent MTs have never been specifically visualized.
Kamasaki, Tomoko, O’Toole, Eileen, Kita, Shigeo, Osumi, Masako, Usukura, Jiro, McIntosh, J. Richard, Goshima, Gohta   +6 more
openaire   +3 more sources

Promiscuous Binding of Microprotein Mozart1 to γ-Tubulin Complex Mediates Specific Subcellular Targeting to Control Microtubule Array Formation

Cell Reports, 2020
Summary: How γ-tubulin ring complex (γ-TuRC), a master template for microtubule nucleation, is spatially and temporally regulated for the assembly of new microtubule arrays remains unclear.
Tzu-Lun Huang, Hsiu-Jung Wang, Ya-Chieh Chang, Shao-Win Wang, Kuo-Chiang Hsia   +4 more
doaj   +1 more source

A continuous model for microtubule dynamics with catastrophe, rescue and nucleation processes

, 2009
Microtubules are a major component of the cytoskeleton distinguished by highly dynamic behavior both in vitro and in vivo. We propose a general mathematical model that accounts for the growth, catastrophe, rescue and nucleation processes in the ...
A. Quarteroni, Jack A. Tuszyński, N. M. Rusan, P. M. Bayley, Peter Hinow, R. F. Gildersleeve, Vahid Rezania   +6 more
core   +1 more source

Generation and Characterization of a Tissue-Specific Centrosome Indicator Mouse Line. [PDF]

, 2016
Centrosomes are major microtubule organizing centers (MTOCs) that play an important role in chromosome segregation during cell division. Centrosomes provide a stable anchor for microtubules, constituting the centers of the spindle poles in mitotic cells,
Chen, Ju, Evans, Sylvia M, Hirai, Maretoshi   +2 more
core   +2 more sources