Microtubule oscillations. Role of nucleation and microtubule number concentration.
Journal of Biological Chemistry, 1990 Microtubules are capable of performing synchronized oscillations of assembly and disassembly which has been explained by reaction mechanisms involving tubulin subunits, oligomers, microtubules, and GTP. Here we address the question of how microtubule nucleation or their number concentration affects the oscillations.
Obermann, H. +3 more
openaire +3 more sources
Self-organized dynamics and the transition to turbulence of confined active nematics
, 2019 We study how confinement transforms the chaotic dynamics of bulk microtubule-based active nematics into regular spatiotemporal patterns. For weak confinements, multiple continuously nucleating and annihilating topological defects self-organize into ...
Aghvami, S. Ali +6 more
core +1 more source
Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells [PDF]
, 2009 © The Authors, 2009 . This article is distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. The definitive version was published in Journal of Cell Biology 186 (2009): 727-738, doi:10.1083/jcb ...
Griffis, Eric R. +2 more
core +5 more sources
The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation [PDF]
, 2015 Unlike other organisms that have evolved distinct H2A variants for different functions, Drosophila melanogaster has just one variant which is capable of filling many roles.
Cenci, Giovanni, Verni', Fiammetta
core +1 more source
Local actin nucleation tunes centrosomal microtubule nucleation during passage through mitosis [PDF]
The EMBO Journal, 2019 Cells going through mitosis undergo precisely timed changes in cell shape and organisation, which serve to ensure the fair partitioning of cellular components into the two daughter cells. These structural changes are driven by changes in actin filament and microtubule dynamics and organisation.
Francesca Farina +11 more
openaire +5 more sources
S. pombe kinesins-8 promote both nucleation and catastrophe of microtubules.
PLoS ONE, 2012 The kinesins-8 were originally thought to be microtubule depolymerases, but are now emerging as more versatile catalysts of microtubule dynamics. We show here that S.
Muriel Erent +2 more
doaj +1 more source
Advanced Science, EarlyView.YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang +8 more
wiley +1 more source
HURP facilitates spindle assembly by stabilizing microtubules and working synergistically with TPX2
Nature CommunicationsIn vertebrate spindles, most microtubules are formed via branching microtubule nucleation, whereby microtubules nucleate along the side of pre-existing microtubules.
Venecia Alexandria Valdez +4 more
doaj +1 more source
Modular assembly of the principal microtubule nucleator γ-TuRC
Nature Communications, 2022 The human microtubule nucleator γ-TuRC is composed of more than thirty subunits, including actin. Here the authors reveal the structural mechanism of modular γ-TuRC assembly and show a functional role of actin in microtubule nucleation.
Martin Würtz +10 more
doaj +1 more source
HSPB1 facilitates the formation of non-centrosomal microtubules [PDF]
, 2013 The remodeling capacity of microtubules (MT) is essential for their proper function. In mammals, MTs are predominantly formed at the centrosome, but can also originate from non-centrosomal sites, a process that is still poorly understood.
Almeida-Souza, Leonardo +5 more
core +5 more sources