Results 81 to 90 of about 34,353 (227)

From Droplet to Diagnosis: Spatio‐Temporal Pattern Recognition in Drying Biofluids

Advanced Intelligent Systems, EarlyView.
This article integrates machine learning (ML) with the spatio‐temporal evolution of biofluid droplets to reveal how drying and self‐assembly encode distinctive compositional fingerprints. By leveraging textural features and interpretable ML, it achieves robust classification of blood abnormalities with over 95% accuracy.
Anusuya Pal, Amalesh Gope, Miho Yanagisawa   +2 more
wiley   +1 more source

Microtubules gate tau condensation to spatially regulate microtubule functions. [PDF]

, 2019
Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia1, yet the physiological state of tau molecules within cells remains unclear.
A Ettinger, A Hernandez-Vega, A Kremer, A Seitz, Aileen J. Lam, AR Duan, B Niewidok, BY Monroy, Dan W. Nowakowski, DP McVicker, DP McVicker, EH Kellogg, H Hagiwara, H Zempel, HT Hoang, J Baumbach, JA Garcia-Leon, Jisoo Han, K Tepper, Kassandra M. Ori-McKenney, KM Ori-McKenney, KS Hubbard, L Qiang, L Urnavicius, LC Kapitein, M Goedert, M Vershinin, M Vershinin, MH Hinrichs, Michael Vershinin, PA Gutierrez, R Dixit, R Zhang, RD Vale, Richard J. McKenney, RJ McKenney, RJ McKenney, Ruensern Tan, S Ambadipudi, S Konzack, S Wegmann, S Wegmann, Sergi Simó, SR White, Tracy Tan, V Makrides, W Yu, XH Li   +47 more
core   +1 more source

Interaction Between Actin and Microtubules During Plant Development

Cytoskeleton, EarlyView.
ABSTRACT The dynamic interaction between actin filaments (AFs) and microtubules (MTs) plays a crucial role in regulating key developmental and physiological processes in plant cells, particularly in the formation of specialized cell types with distinct shapes and functions, such as pollen tubes, trichomes, and leaf epidermal cells.
Zining Wu, Lidong Gao, M. Arif Ashraf, Qiong Nan   +3 more
wiley   +1 more source

The Dis1/Stu2/XMAP215 Family Gene FgStu2 Is Involved in Vegetative Growth, Morphology, Sexual and Asexual Reproduction, Pathogenicity and DON Production of Fusarium graminearum

Frontiers in Microbiology, 2020
The conserved Dis1/Stu2/XMAP215 microtubule association proteins (MAPs) family plays an important role in microtubule dynamics, nucleation, and kinetochore-microtubule attachments.
Yuanye Zhu, Yuanshuai Zhang, Na Liu, Weichao Ren, Yiping Hou, Yabing Duan, Xiushi Song, Mingguo Zhou   +7 more
doaj   +1 more source

A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells [PDF]

, 2018
The two centrioles of the centrosome in quiescent cells are inherently asymmetric structures that differ in age, morphology and function. How these asymmetric properties are established and maintained during quiescence remains unknown. Here, we show that
Betleja, Ewelina, Cheng, Tao, Mahjoub, Moe R, Nanjundappa, Rashmi   +3 more
core   +2 more sources

Making Two out of One: Kinesin Motors Driving Plant Cell Division

Cytoskeleton, EarlyView.
ABSTRACT The Kinesin superfamily of microtubule dependent motors is present in all eukaryotes. Not all of the subfamilies are represented in all kingdoms, and the ones that are do not always show conserved functions. Tight control of the cytoskeleton is essential for proper progression and completion of mitosis and cytokinesis, and key functions are ...
Choy Kriechbaum, Sabine Müller
wiley   +1 more source

The mitotic spindle protein CKAP2 potently increases formation and stability of microtubules

eLife, 2022
Cells increase microtubule dynamics to make large rearrangements to their microtubule cytoskeleton during cell division. Changes in microtubule dynamics are essential for the formation and function of the mitotic spindle, and misregulation can lead to ...
Thomas S McAlear, Susanne Bechstedt
doaj   +1 more source

Exotic mitotic mechanisms [PDF]

, 2012
The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Drechsler, Hauke, McAinsh, Andrew D.
core   +1 more source

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation

Cytoskeleton, EarlyView.
ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda, Joana N. Bugalhao, Marco Antonio Dias Louro, Andreia Henriques‐Soares, Monica Bettencourt‐Dias   +4 more
wiley   +1 more source

Collective dynamics of actin and microtubule and its crosstalk mediated by FHDC1

Frontiers in Cell and Developmental Biology
The coordination between actin and microtubule network is crucial, yet this remains a challenging problem to dissect and our understanding of the underlying mechanisms remains limited.
Chee San Tong, Chee San Tong, Maohan Su, Maohan Su, Maohan Su, He Sun, Xiang Le Chua, Xiang Le Chua, Ding Xiong, Su Guo, Ravin Raj, Nicole Wen Pei Ong, Ann Gie Lee, Yansong Miao, Min Wu, Min Wu, Min Wu   +16 more
doaj   +1 more source