Results 1 to 10 of about 334,432 (342)

Are microtubules tension sensors? [PDF]

Nature Communications, 2019
Mechanical signals play many roles in cell and developmental biology. Several mechanotransduction pathways have been uncovered, but the mechanisms identified so far only address the perception of stress intensity.
olivier Hamant, Jacques Dumais
exaly   +9 more sources

Microtubules and Microtubule-Associated Proteins. [PDF]

Cold Spring Harbor Perspectives in Biology, 2018
Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell.
H. Goodson, Erin M. Jonasson
semanticscholar   +3 more sources

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

Nature Medicine, 2018
Detyrosinated microtubules provide mechanical resistance that can impede the motion of contracting cardiomyocytes. However, the functional effects of microtubule detyrosination in heart failure or in human hearts have not previously been studied.
Christina Yingxian Chen, Matthew A Caporizzo, Kenneth C Bedi   +2 more
exaly   +2 more sources

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle

Nature Communications, 2015
In striated muscle, X-ROS is the mechanotransduction pathway by which mechanical stress transduced by the microtubule network elicits reactive oxygen species.
Jaclyn P Kerr, Daniel A Harki, Roberto Raiteri   +2 more
exaly   +2 more sources

Resolving bundled microtubules using anti-tubulin nanobodies

Nature Communications, 2015
Microtubules are hollow biopolymers of 25-nm diameter and are key constituents of the cytoskeleton. In neurons, microtubules are organized differently between axons and dendrites, but their precise organization in different compartments is not completely
Marina Mikhaylova, Robert van den Berg, Jalmar Teeuw   +2 more
exaly   +2 more sources

Microtubules and resistance to tubulin-binding agents

Nature Reviews Cancer, 2010
Maria Kavallaris
exaly   +3 more sources

Drugs that target dynamic microtubules: A new molecular perspective

Medicinal Research Reviews, 2011
Ritu Aneja
exaly   +2 more sources

Microtubules in Bacteria: Ancient Tubulins Build a Five-Protofilament Homolog of the Eukaryotic Cytoskeleton [PDF]

, 2011
Microtubules play crucial roles in cytokinesis, transport, and motility, and are therefore superb targets for anti-cancer drugs. All tubulins evolved from a common ancestor they share with the distantly related bacterial cell division protein FtsZ, but ...
A Briegel, A Marchler-Bauer, A. J Koster, A. J Martin-Galiano, Alasdair W. McDowall, B Miroux, C Jenkins, C Suloway, C. A Sontag, C. A Sontag, C. H Aylett, C. V Iancu, D Bermudes, D Nicastro, D Schlieper, D. N Mastronarde, D. N Mastronarde, D. P Devos, E Nogales, E Nogales, E Nogales, E Nogales, E. F Pettersen, E. G Reynaud, E. I Tocheva, F Amat, Giulio Petroni, Grant J. Jensen, H Erickson, H Sui, H. P Erickson, J Cope, J Lowe, J. B Heymann, J. D Thompson, J. D Wisotzkey, J. O McInerney, J. R McIntosh, K. C Lee, K. S Makarova, K. T Tokuyasu, K. T Tokuyasu, L Gan, L Ni, L. A Amos, L. A Amos, Linda Amos, M Pilhofer, M Pilhofer, M Pilhofer, M Takeda, M Wagner, M. S Ladinsky, M. S Ladinsky, Mark S. Ladinsky, Martin Pilhofer, P Forterre, P. J Keeling, R. I Koning, S Vaughan, S. K Dutcher, S. Q Zheng, T Muller, T. K Attwood, W Ludwig, W. F Tivol, Z Li   +66 more
core   +11 more sources

Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro [PDF]

, 2016
Microtubule structure and functions have been widely studied in vitro and in cells. Research has shown that cysteines on tubulin play a crucial role in the polymerization of microtubules.
Prabhune, Meenakshi, Rehfeldt, Florian, Schmidt, Christoph F., von Roden, Kerstin   +3 more
core   +6 more sources

Nanomechanics of Microtubules [PDF]

Physical Review Letters, 2002
We have determined the mechanical anisotropy of a single microtubule by simultaneously measuring the Young's and the shear moduli in vitro. This was achieved by elastically deforming the microtubule deposited on a substrate tailored by electron-beam lithography with a tip of an atomic force microscope.
B. Babić, G. A. D. Briggs, Andrzej J. Kulik, Christian Schönenberger, Sandor Kasas, Sandor Kasas, W. Benoit, Andras Kis, László Forró, Stefan Catsicas   +9 more
openaire   +3 more sources