Results 11 to 20 of about 217,642 (298)

Microtubules and Microtubule-Associated Proteins [PDF]

Cold Spring Harbor Perspectives in Biology, 2018
Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell. Key to these functions is the fact that microtubules are "dynamic." As with actin, the polymer dynamics are driven by ...
Holly V, Goodson, Erin M, Jonasson
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Nanomechanics of Microtubules [PDF]

Physical Review Letters, 2002
We have determined the mechanical anisotropy of a single microtubule by simultaneously measuring the Young's and the shear moduli in vitro. This was achieved by elastically deforming the microtubule deposited on a substrate tailored by electron-beam lithography with a tip of an atomic force microscope.
Kis, A, Kasas, S, Babic, B, Kulik, AJ, Benoit, W, Briggs, GAD, Schonenberger, C, Catsicas, S, Forro, L   +8 more
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Ectopic A-lattice seams destabilize microtubules [PDF]

, 2014
Natural microtubules typically include one A-lattice seam within an otherwise helically symmetric B-lattice tube. It is currently unclear how A-lattice seams influence microtubule dynamic instability.
A des Georges, A Desai, A Dimitrov, A Grafmuller, AA Hyman, B Vitre, D Chretien, D Chretien, D Chretien, D Chretien, D Panda, D Sept, DJ Odde, DN Drechsel, DP Dias, DR Drummond, E Nogales, EM Mandelkow, EM Mandelkow, FM Coquelle, G Brouhard, G Margolin, H Bowne-Anderson, H Sui, IM Crevel, JG Cueva, JL Hoog, JR McIntosh, JR Simon, JS Kaye, KE Busch, L Amos, L Sandblad, LG Tilney, LM Rice, M Braun, M Caplow, M Caplow, M Katsuki, M Katsuki, M Kikkawa, MK Gardner, MK Gardner, N Galjart, P Bieling, R Dallai, RA Walker, RA Walker, SP Maurer, SP Maurer, T Mitchison, T Mitchison, Y Komarova, YH Song, ZC Zhu   +54 more
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Isolation of Microtubules and Microtubule Proteins

Current Protocols in Cell Biology, 2008
AbstractThis unit describes various protocols for the isolation and purification of the main constituents of microtubules, chiefly α‐ and β‐tubulin, and the most significant microtubule associated proteins (MAPs), specifically MAP1A, MAP1B, MAP2, and tau.
Ávila, Jesús, Soares, Helena, Fanarraga, Mónica L., Zabala, Juan Carlos   +3 more
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Actin–microtubule coordination at growing microtubule ends [PDF]

Nature Communications, 2014
To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood.
Preciado López, Magdalena, Huber, Florian, Grigoriev, Ilya, Steinmetz, Michel O., Akhmanova, Anna, Koenderink, Gijsje H., Dogterom, Marileen   +6 more
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Microtubules in Bacteria: Ancient Tubulins Build a Five-Protofilament Homolog of the Eukaryotic Cytoskeleton [PDF]

, 2011
Microtubules play crucial roles in cytokinesis, transport, and motility, and are therefore superb targets for anti-cancer drugs. All tubulins evolved from a common ancestor they share with the distantly related bacterial cell division protein FtsZ, but ...
A Briegel, A Marchler-Bauer, A. J Koster, A. J Martin-Galiano, Alasdair W. McDowall, B Miroux, C Jenkins, C Suloway, C. A Sontag, C. A Sontag, C. H Aylett, C. V Iancu, D Bermudes, D Nicastro, D Schlieper, D. N Mastronarde, D. N Mastronarde, D. P Devos, E Nogales, E Nogales, E Nogales, E Nogales, E. F Pettersen, E. G Reynaud, E. I Tocheva, F Amat, Giulio Petroni, Grant J. Jensen, H Erickson, H Sui, H. P Erickson, J Cope, J Lowe, J. B Heymann, J. D Thompson, J. D Wisotzkey, J. O McInerney, J. R McIntosh, K. C Lee, K. S Makarova, K. T Tokuyasu, K. T Tokuyasu, L Gan, L Ni, L. A Amos, L. A Amos, Linda Amos, M Pilhofer, M Pilhofer, M Pilhofer, M Takeda, M Wagner, M. S Ladinsky, M. S Ladinsky, Mark S. Ladinsky, Martin Pilhofer, P Forterre, P. J Keeling, R. I Koning, S Vaughan, S. K Dutcher, S. Q Zheng, T Muller, T. K Attwood, W Ludwig, W. F Tivol, Z Li   +66 more
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Lab-on-chip microscope platform for electro-manipulation of a dense microtubules network

Scientific Reports, 2022
Pulsed electric field (PEF) technology is promising for the manipulation of biomolecular components and has potential applications in biomedicine and bionanotechnology.
Daniel Havelka, Ilia Zhernov, Michal Teplan, Zdeněk Lánský, Djamel Eddine Chafai, Michal Cifra   +5 more
doaj   +1 more source

A "MICROTUBULE" IN A BACTERIUM [PDF]

The Journal of Cell Biology, 1967
A study of the anchorage of the flagella in swarmers of Proteus mirabilis led to the incidental observation of microtubules. These microtubules were found in thin sections and in whole mount preparations of cells from which most of the content had been released by osmotic shock before staining negatively with potassium phosphotungstate (PTA).
W, van Iterson, J F, Hoeniger, E, Nijman van Zanten   +2 more
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Anaphase Chromosomes in Crane-Fly Spermatocytes Treated With Taxol (Paclitaxel) Accelerate When Their Kinetochore Microtubules Are Cut: Evidence for Spindle Matrix Involvement With Spindle Forces

Frontiers in Cell and Developmental Biology, 2018
Various experiments have indicated that anaphase chromosomes continue to move after their kinetochore microtubules are severed. The chromosomes move poleward at an accelerated rate after the microtubules are cut but they slow down 1–3 min later and move ...
Arthur Forer, Rozhan Sheykhani, Michael W. Berns, Michael W. Berns   +3 more
doaj   +1 more source

Microtubule dynamics depart from wormlike chain model [PDF]

, 2007
Thermal shape fluctuations of grafted microtubules were studied using high resolution particle tracking of attached fluorescent beads. First mode relaxation times were extracted from the mean square displacement in the transverse coordinate.
Ernst-Ludwig Florin, Erwin Frey, Francesco Pampaloni, J. Gere, Katja M. Taute, O. Kratky   +5 more
core   +2 more sources