Results 11 to 20 of about 249,538 (351)

Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro. [PDF]

PLoS ONE, 2016
Microtubule structure and functions have been widely studied in vitro and in cells. Research has shown that cysteines on tubulin play a crucial role in the polymerization of microtubules.
Meenakshi Prabhune, Kerstin von Roden, Florian Rehfeldt, Christoph F Schmidt   +3 more
doaj   +5 more sources

Measuring and modeling polymer concentration profiles near spindle boundaries argues that spindle microtubules regulate their own nucleation

New Journal of Physics, 2018
Spindles are self-organized microtubule-based structures that segregate chromosomes during cell division. The mass of the spindle is controlled by the balance between microtubule turnover and nucleation. The mechanisms that control the spatial regulation
Bryan Kaye, Olivia Stiehl, Peter J Foster, Michael J Shelley, Daniel J Needleman, Sebastian Fürthauer   +5 more
doaj   +2 more sources

Quantitative mapping of dense microtubule arrays in mammalian neurons

eLife, 2021
The neuronal microtubule cytoskeleton underlies the polarization and proper functioning of neurons, amongst others by providing tracks for motor proteins that drive intracellular transport.
Eugene A Katrukha, Daphne Jurriens, Desiree M Salas Pastene, Lukas C Kapitein   +3 more
doaj   +1 more source

Effects of three microtubule-associated proteins (MAP2, MAP4, and Tau) on microtubules’ physical properties and neurite morphology

Scientific Reports, 2023
The physical properties of cytoskeletal microtubules have a multifaceted effect on the expression of their cellular functions. A superfamily of microtubule-associated proteins, MAP2, MAP4, and tau, promote the polymerization of microtubules, stabilize ...
Kohei Nishida, Kosuke Matsumura, Miki Tamura, Takuto Nakamichi, Keiya Shimamori, Masahiro Kuragano, Arif Md. Rashedul Kabir, Akira Kakugo, Susumu Kotani, Naoki Nishishita, Kiyotaka Tokuraku   +10 more
doaj   +1 more source

Microtubules and Microtubule-Associated Proteins [PDF]

Cold Spring Harbor Perspectives in Biology, 2018
Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell. Key to these functions is the fact that microtubules are "dynamic." As with actin, the polymer dynamics are driven by ...
Holly V. Goodson, Erin M. Jonasson
openaire   +2 more sources

Binding of Tau-derived peptide-fused GFP to plant microtubules in Arabidopsis thaliana.

PLoS ONE, 2023
Studies on how exogenous molecules modulate properties of plant microtubules, such as their stability, structure, and dynamics, are important for understanding and modulating microtubule functions in plants.
Hiroshi Inaba, Kazusato Oikawa, Kazuya Ishikawa, Yutaka Kodama, Kazunori Matsuura, Keiji Numata   +5 more
doaj   +1 more source

Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality. [PDF]

PLoS ONE, 2014
Aurora-B is the kinase subunit of the Chromosome Passenger Complex (CPC), a key regulator of mitotic progression that corrects improper kinetochore attachments and establishes the spindle midzone.
Michael Noujaim, Susanne Bechstedt, Michal Wieczorek, Gary J Brouhard   +3 more
doaj   +1 more source

Actin–Microtubule Crosstalk Imparts Stiffness to the Contractile Ring in Fission Yeast

Cells, 2023
Actin–microtubule interactions are critical for cell division, yet how these networks of polymers mutually influence their mechanical properties and functions in live cells remains unknown.
Kimberly Bellingham-Johnstun, Zoe L. Tyree, Jessica Martinez-Baird, Annelise Thorn, Caroline Laplante   +4 more
doaj   +1 more source

Microtubules in Bacteria: Ancient Tubulins Build a Five-Protofilament Homolog of the Eukaryotic Cytoskeleton [PDF]

, 2011
Microtubules play crucial roles in cytokinesis, transport, and motility, and are therefore superb targets for anti-cancer drugs. All tubulins evolved from a common ancestor they share with the distantly related bacterial cell division protein FtsZ, but ...
A Briegel, A Marchler-Bauer, A. J Koster, A. J Martin-Galiano, Alasdair W. McDowall, B Miroux, C Jenkins, C Suloway, C. A Sontag, C. A Sontag, C. H Aylett, C. V Iancu, D Bermudes, D Nicastro, D Schlieper, D. N Mastronarde, D. N Mastronarde, D. P Devos, E Nogales, E Nogales, E Nogales, E Nogales, E. F Pettersen, E. G Reynaud, E. I Tocheva, F Amat, Giulio Petroni, Grant J. Jensen, H Erickson, H Sui, H. P Erickson, J Cope, J Lowe, J. B Heymann, J. D Thompson, J. D Wisotzkey, J. O McInerney, J. R McIntosh, K. C Lee, K. S Makarova, K. T Tokuyasu, K. T Tokuyasu, L Gan, L Ni, L. A Amos, L. A Amos, Linda Amos, M Pilhofer, M Pilhofer, M Pilhofer, M Takeda, M Wagner, M. S Ladinsky, M. S Ladinsky, Mark S. Ladinsky, Martin Pilhofer, P Forterre, P. J Keeling, R. I Koning, S Vaughan, S. K Dutcher, S. Q Zheng, T Muller, T. K Attwood, W Ludwig, W. F Tivol, Z Li   +66 more
core   +11 more sources

Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

eLife, 2022
In many eukaryotic cells, directed molecular transport occurs along microtubules. Within neuronal axons, transport over vast distances particularly relies on uniformly oriented microtubules, whose plus-ends point towards the distal axon tip ...
Maximilian AH Jakobs, Assaf Zemel, Kristian Franze   +2 more
doaj   +1 more source