Results 31 to 40 of about 228,374 (345)

Actin–microtubule coordination at growing microtubule ends [PDF]

Nature Communications, 2014
To power dynamic processes in cells, the actin and microtubule cytoskeletons organize into complex structures. Although it is known that cytoskeletal coordination is vital for cell function, the mechanisms by which cross-linking proteins coordinate actin and microtubule activities remain poorly understood.
Preciado López, Magdalena, Huber, Florian, Grigoriev, Ilya, Steinmetz, Michel O., Akhmanova, Anna, Koenderink, Gijsje H., Dogterom, Marileen   +6 more
openaire   +6 more sources

Bistability and oscillations in cooperative microtubule and kinetochore dynamics in the mitotic spindle [PDF]

, 2020
In the mitotic spindle microtubules attach to kinetochores via catch bonds during metaphase, and microtubule depolymerization forces give rise to stochastic chromosome oscillations. We investigate the cooperative stochastic microtubule dynamics in spindle models consisting of ensembles of parallel microtubules, which attach to a kinetochore via elastic
arxiv   +1 more source

Dynamic instability of microtubules: effect of catastrophe-suppressing drugs [PDF]

, 2005
Microtubules are stiff filamentary proteins that constitute an important component of the cytoskeleton of cells. These are known to exhibit a dynamic instability.
A. Vandecandelaere, Ambarish Kunwar, B. Alberts, Debashish Chowdhury, H. P. Erickson, Pankaj Kumar Mishra, Sutapa Mukherji   +6 more
core   +2 more sources

Formins and microtubules

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010
Formins have recently been recognized as prominent regulators of the microtubule (MT) cytoskeleton where they modulate the dynamics of selected MTs in interphase and mitosis. The association of formins with the MT cytoskeleton and their action on MT dynamics are relatively unexplored areas, yet growing evidence supports a direct role in their ...
Gregg G. Gundersen, Francesca Bartolini
openaire   +3 more sources

Chlamydia Hijacks ARF GTPases To Coordinate Microtubule Posttranslational Modifications and Golgi Complex Positioning. [PDF]

, 2017
The intracellular bacterium Chlamydia trachomatis develops in a parasitic compartment called the inclusion. Posttranslationally modified microtubules encase the inclusion, controlling the positioning of Golgi complex fragments around the inclusion.
Agata Nawrotek, Cheryl A. Dooley, Claudette M. St. Croix, Craig R. Roy, Fabienne Paumet, Howard A. Shuman, Jacqueline Cherfils, Jordan Wesolowski, Mary M. Weber, Mike Calderon, Ted Hackstadt   +10 more
core   +3 more sources

Microtubules, microtubule-interfering agents and apoptosis.

Apoptosis : an international journal on programmed cell death, 2003
Microtubules are dynamic polymers that play crucial roles in a large number of cellular functions. Their pivotal role in mitosis makes them a target for the development of anticancer drugs. Microtubule-damaging agents suppress microtubule dynamics, leading to disruption of the mitotic spindle in dividing cells, cell cycle arrest at M phase, and late ...
Mollinedo, Faustino, Gajate, Consuelo
openaire   +4 more sources

Modeling the Effects of Drug Binding on the Dynamic Instability of Microtubules [PDF]

Phys. Biol. 8:056004 (2011), 2010
We propose a stochastic model that accounts for the growth, catastrophe and rescue processes of steady state microtubules assembled from MAP-free tubulin. Both experimentally and theoretically we study the perturbation of microtubule dynamic instability by S-methyl-D-DM1, a synthetic derivative of the microtubule-targeted agent maytansine and a ...
arxiv   +1 more source

The Mating-specific Gα Interacts with a Kinesin-14 and Regulates Pheromone-induced Nuclear Migration in Budding Yeast [PDF]

, 2009
As a budding yeast cell elongates toward its mating partner, cytoplasmic microtubules connect the nucleus to the cell cortex at the growth tip.
Cooper, John A, Draper, Edward, Durbrovskyi, Oleksii, Metodiev, Metodi V, Nelson, Scott A, Stone, David E, Zaichick, Sofia V   +6 more
core   +3 more sources

A "MICROTUBULE" IN A BACTERIUM [PDF]

The Journal of Cell Biology, 1967
A study of the anchorage of the flagella in swarmers of Proteus mirabilis led to the incidental observation of microtubules. These microtubules were found in thin sections and in whole mount preparations of cells from which most of the content had been released by osmotic shock before staining negatively with potassium phosphotungstate (PTA).
Judith F. M. Hoeniger, Woutera van Iterson, Eva Nijman van Zanten   +2 more
openaire   +3 more sources

Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner. [PDF]

, 2019
The spindle assembly checkpoint (SAC) prevents anaphase until all kinetochores attach to the spindle. Each mammalian kinetochore binds many microtubules, but how many attached microtubules are required to turn off the checkpoint, and how the kinetochore ...
Akiyoshi, Alushin, Aravamudhan, Ballister, Barisic, Cane, Cheeseman, Chen, Ciferri, Clute, David, De Antoni, DeLuca, DeLuca, DeLuca, Dick, Dudka, Elting, Elting, Etemad, Etemad, Funabiki, Gassmann, Guimaraes, Hengeveld, Hewitt, Hiruma, Howell, Howell, Hueschen, Janssen, Jelluma, Ji, Johnston, Jonathan Kuhn, Kajtez, Khodjakov, Kuhn, London, Long, Lukinavičius, Maciejowski, Magidson, Maldonado, Maresca, Martin-Lluesma, Matson, McEwen, McIntosh, McKinley, Nijenhuis, Orth, O’Connell, Peterson, Pinsky, Rieder, Rieder, Santaguida, Sarangapani, Saurin, Shah, Sikirzhytski, Sikirzhytski, Sivakumar, Sophie Dumont, Sundin, Suzuki, Suzuki, Tanaka, Tauchman, Uchida, Uetake, Vanoosthuyse, Volkov, Wan, Waters, Wendell, Wojcik, Yoo, Zaytsev, Zaytsev   +80 more
core   +1 more source