Results 61 to 70 of about 228,374 (345)

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

Molecular Oncology, EarlyView.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

Dissecting the molecular mechanism underlying the intimate relationship between cellulose microfibrils and cortical microtubules

Frontiers in Plant Science, 2014
A central question in plant cell development is how the cell wall determines directional cell expansion and therefore the final shape of the cell. As the major load-bearing component of the cell wall, cellulose microfibrils are laid down transversely to ...
Lei eLei, Shundai eLi, Logan eBashline, Ying eGu   +3 more
doaj   +1 more source

Redundant mechanisms recruit actin into the contractile ring in silkworm spermatocytes. [PDF]

PLoS Biology, 2008
Cytokinesis is powered by the contraction of actomyosin filaments within the newly assembled contractile ring. Microtubules are a spindle component that is essential for the induction of cytokinesis. This induction could use central spindle and/or astral
Wei Chen, Margit Foss, Kuo-Fu Tseng, Dahong Zhang   +3 more
doaj   +1 more source

Microtubule length distributions in the presence of protein-induced severing

, 2010
Microtubules are highly regulated dynamic elements of the cytoskeleton of eukaryotic cells. One of the regulation mechanisms observed in living cells is the severing by the proteins katanin and spastin.
B. Alberts, Bela M. Mulder, L. Quarmby, Simon H. Tindemans   +3 more
core   +1 more source

Immunolocalization of dually phosphorylated MAPKs in dividing root meristem cells of Vicia faba, Pisum sativum, Lupinus luteus and Lycopersicon esculentum [PDF]

, 2015
Key message In plants, phosphorylated MAPKs display constitutive nuclear localization; however, not all studied plant species show co-localization of activated MAPKs to mitotic microtubules.
A Bessard, A Neupane, A Neupane, A Pitzschke, AK Sinha, Aneta Żabka, AP Smertenko, D Ortiz-Masia, F Kong, G Komis, G Taj, G Tena, H Nakagami, J Müller, J Schindelin, Janusz Maszewski, Joanna Bernasińska, K Kosetsu, Karolina Matczak, Konrad Winnicki, L Bögre, M Beck, M Beck, M Cargnello, M Fernandez-Pascual, M Ohori, M Ovečka, M Sasabe, M Wrzaczek, MA González Besteiro, MAPK Group, MM Horne, NS Mishra, O Šamajová, PJ Krysan, R Ulm, R Ulm, RM Perrett, T Hayashi, V Smékalová, W Ligterink, X Liu, X Qian   +42 more
core   +2 more sources

Cytoplasmic Dynein Transports Axonal Microtubules in a Polarity-Sorting Manner

Cell Reports, 2017
Axonal microtubules are predominantly organized into a plus-end-out pattern. Here, we tested both experimentally and with computational modeling whether a motor-based polarity-sorting mechanism can explain this microtubule pattern.
Anand N. Rao, Ankita Patil, Mark M. Black, Erin M. Craig, Kenneth A. Myers, Howard T. Yeung, Peter W. Baas   +6 more
doaj   +1 more source

Sites of glucose transporter-4 vesicle fusion with the plasma membrane correlate spatially with microtubules. [PDF]

PLoS ONE, 2012
In adipocytes, vesicles containing glucose transporter-4 (GLUT4) redistribute from intracellular stores to the cell periphery in response to insulin stimulation.
Jennine M Dawicki-McKenna, Yale E Goldman, E Michael Ostap   +2 more
doaj   +1 more source

Diffusion of myosin V on microtubules [PDF]

, 2011
Organelle transport in eukaryotes employs both microtubule and actin tracks to deliver cargo effectively to their destinations, but the question of how the two systems cooperate is still largely unanswered.
Abdel Motaal, Basma, Schliwa, Manfred, Voith von Voithenberg, Lena, Zimmermann, Dennis, Ökten, Zeynep   +4 more
core   +1 more source

Microtubules and motors [PDF]

Molecular Biology of the Cell, 2012
New tools and approaches are providing exciting new insights into the structure and function of motors and microtubules and their contributions to cell migration, mitosis, and neuronal function. Janel Titus, from the Wadsworth laboratory (University of Massachusetts, Amherst), discussed the regulation of the plus end–directed mitotic motor Eg5 by ...
Jonathon Howard, Pat Wadsworth
openaire   +1 more source