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Extracellular Vesicles and Their Convergence with Viral Pathways [PDF]

Advances in Virology, 2012
Extracellular vesicles (microvesicles), such as exosomes and shed microvesicles, contain a variety of molecules including proteins, lipids, and nucleic acids.
Thomas Wurdinger, NaTosha N. Gatson, Leonora Balaj, Balveen Kaur, Xandra O. Breakefield, D. Michiel Pegtel   +5 more
doaj   +6 more sources

Response of the tegument of Fasciola hepatica to infection and immunization sera in vitro [PDF]

Parasitology
The migratory phase is a critical time for Fasciola hepatica as it must locate, penetrate and migrate through the alimentary tract to the liver parenchyma whilst under attack from the host immune response.
Clive E. Bennett, Adam P.S. Bennett, Robert E.B. Hanna, Mark W. Robinson   +3 more
doaj   +2 more sources

Rottlerin Stimulates Exosome/Microvesicle Release Via the Increase of Ceramide Levels Mediated by Ampk in an In Vitro Model of Intracellular Lipid Accumulation

Biomedicines, 2022
Exosomes/microvesicles originate from multivesicular bodies that allow the secretion of endolysosome components out of the cell. In the present work, we investigated the effects of rottlerin, a polyphenol, on exosome/microvesicle secretion in a model of ...
Yessenia L. Molina, David García-Seisdedos, Bohdan Babiy, Milagros Lerma, Javier Martínez-Botas, María J. Casarejos, María T. Vallejo, Diego Gómez-Coronado, Miguel A. Lasunción, Óscar Pastor, Rebeca Busto   +10 more
doaj   +1 more source

Analysis of synaptic-like microvesicle exocytosis of B-cells using a live imaging technique. [PDF]

, 2014
Pancreatic β-cells play central roles in blood glucose homeostasis. Beside insulin, these cells release neurotransmitters and other signaling molecules stored in synaptic-like microvesicles (SLMVs).
Bergeron, A., Bezzi, P., Pucci, L., Regazzi, R.   +3 more
core   +13 more sources

Tp47-Induced Monocyte-Derived Microvesicles Promote the Adherence of THP-1 Cells to Human Umbilical Vein Endothelial Cells via an ERK1/2–NF-κB Signaling Cascade

Microbiology Spectrum, 2023
The Treponema pallidum membrane protein Tp47 induces immunocyte adherence to vascular cells and contributes to vascular inflammation. However, it is unclear whether microvesicles are functional inflammatory mediators between vascular cells and ...
M. Wang, J.-W. Xie, Y.-W. Zheng, X.-T. Wang, D.-Y. Yi, Y. Lin, M.-L. Tong, L.-R. Lin   +7 more
doaj   +1 more source

M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors

Journal of Nanobiotechnology, 2021
Cancer cells and cancer stem cells (CSCs) are the major players of cancer malignancy and metastasis, but they are extremely difficult to access. Inspired by the vital role of macrophages and microvesicle-mediated cell–cell communication in tumors, we ...
Yuqi Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Yao Wu, Jiaoying Wang, Siling Wang, Yaping Li, Zhiwen Zhang   +9 more
doaj   +1 more source

Cerebrospinal Fluid of Patients With Alzheimer’s Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles

Frontiers in Aging Neuroscience, 2021
IntroductionIn Alzheimer’s disease, the severity of symptoms is linked to a loss of synaptic density and the spread of pathologically hyperphosphorylated tau.
Janine Utz, Judith Berner, Luis Enrique Muñoz, Luis Enrique Muñoz, Timo Jan Oberstein, Johannes Kornhuber, Martin Herrmann, Martin Herrmann, Juan Manuel Maler, Philipp Spitzer   +9 more
doaj   +1 more source

Endothelial cells release microvesicles that harbour multivesicular bodies and secrete exosomes

Journal of Extracellular Biology, 2023
Extracellular vesicles (EVs) released by endothelial cells support vascular homeostasis. To better understand endothelial cell EV biogenesis, we examined cultured human umbilical vein endothelial cells (HUVECs) prepared by rapid freezing, freeze ...
Jennifer D. Petersen, Elena Mekhedov, Sukhbir Kaur, David D. Roberts, Joshua Zimmerberg   +4 more
doaj   +1 more source

Biodistribution of extracellular vesicles following administration into animals: A systematic review

Journal of Extracellular Vesicles, 2021
In recent years, attention has turned to examining the biodistribution of EVs in recipient animals to bridge between knowledge of EV function in vitro and in vivo. We undertook a systematic review of the literature to summarize the biodistribution of EVs
Matthew Kang, Vanessa Jordan, Cherie Blenkiron, Lawrence W. Chamley   +3 more
doaj   +1 more source

Vesiculation of Red Blood Cells in the Blood Bank: A Multi-Omics Approach towards Identification of Causes and Consequences

Proteomes, 2020
Microvesicle generation is an integral part of the aging process of red blood cells in vivo and in vitro. Extensive vesiculation impairs function and survival of red blood cells after transfusion, and microvesicles contribute to transfusion reactions ...
Joames K. Freitas Leal, Edwin Lasonder, Vikram Sharma, Jürgen Schiller, Giuseppina Fanelli, Sara Rinalducci, Roland Brock, Giel Bosman   +7 more
doaj   +1 more source