Results 1 to 10 of about 15,493 (301)

Rottlerin Stimulates Exosome/Microvesicle Release Via the Increase of Ceramide Levels Mediated by Ampk in an In Vitro Model of Intracellular Lipid Accumulation

Biomedicines, 2022
Exosomes/microvesicles originate from multivesicular bodies that allow the secretion of endolysosome components out of the cell. In the present work, we investigated the effects of rottlerin, a polyphenol, on exosome/microvesicle secretion in a model of ...
Yessenia L. Molina, David García-Seisdedos, Bohdan Babiy, Milagros Lerma, Javier Martínez-Botas, María J. Casarejos, María T. Vallejo, Diego Gómez-Coronado, Miguel A. Lasunción, Óscar Pastor, Rebeca Busto   +10 more
doaj   +2 more sources

M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors

Journal of Nanobiotechnology, 2021
Cancer cells and cancer stem cells (CSCs) are the major players of cancer malignancy and metastasis, but they are extremely difficult to access. Inspired by the vital role of macrophages and microvesicle-mediated cell–cell communication in tumors, we ...
Yuqi Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Yao Wu, Jiaoying Wang, Siling Wang, Yaping Li, Zhiwen Zhang   +9 more
doaj   +2 more sources

Tp47-Induced Monocyte-Derived Microvesicles Promote the Adherence of THP-1 Cells to Human Umbilical Vein Endothelial Cells via an ERK1/2–NF-κB Signaling Cascade [PDF]

Microbiology Spectrum, 2023
The Treponema pallidum membrane protein Tp47 induces immunocyte adherence to vascular cells and contributes to vascular inflammation. However, it is unclear whether microvesicles are functional inflammatory mediators between vascular cells and ...
M. Wang, J.-W. Xie, Y.-W. Zheng, X.-T. Wang, D.-Y. Yi, Y. Lin, M.-L. Tong, L.-R. Lin   +7 more
doaj   +2 more sources

Microvesicle-camouflaged biomimetic nanoparticles encapsulating a metal-organic framework for targeted rheumatoid arthritis therapy

Journal of Nanobiotechnology, 2022
Background Methotrexate (MTX) has been highlighted for Rheumatoid arthritis (RA) treatment, however, MTX does not accumulate well at inflamed sites, and long-term administration in high doses leads to severe side effects.
Yao Wang, Mingli Jia, Xiu Zheng, Chenglong Wang, Yun Zhou, Hong Pan, Yan Liu, Ji Lu, Z. Mei, Chunhong Li   +9 more
semanticscholar   +1 more source

UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment

Frontiers in Immunology, 2022
Ultraviolet B radiation (UVB) has profound effects on human skin that results in a broad spectrum of immunological local and systemic responses and is the major cause of skin carcinogenesis.
T. Frommeyer, M. M. Gilbert, Garrett V. Brittain, Tong Wu, Trang Nguyen, C. Rohan, J. Travers   +6 more
semanticscholar   +1 more source

Selective immunocapture reveals neoplastic human mast cells secrete distinct microvesicle‐ and exosome‐like populations of KIT‐containing extracellular vesicles

Journal of Extracellular Vesicles, 2022
Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other cargo into recipient cells ...
Annika Pfeiffer, Jennifer D. Petersen, Guido H. Falduto, D. Anderson, J. Zimmerberg, D. Metcalfe, A. Olivera   +6 more
semanticscholar   +1 more source

Keratinocyte-derived microvesicle particles mediate Ultraviolet B radiation induced systemic immunosuppression.

Journal of Clinical Investigation, 2021
A complete carcinogen, Ultraviolet B radiation (290-320 nm; UVB), is the major cause of skin cancer. UVB-induced systemic immunosuppression that contributes to photocarcinogenesis is due to the glycerophosphocholine-derived lipid mediator Platelet ...
Langni Liu, A. Awoyemi, Katherine E. Fahy, P. Thapa, C. Borchers, Benita Y Wu, C. McGlone, B. Schmeusser, Zafer Sattouf, C. Rohan, Amy R. Williams, E. Cates, Christina Knisely, Lisa E. Kelly, J. Bihl, D. Cool, R. Sahu, Jinju Wang, Yanfang Chen, C. Rapp, M. Kemp, R. Johnson, J. Travers   +22 more
semanticscholar   +1 more source

Hydrostatic pressure promotes chondrogenic differentiation and microvesicle release from human embryonic and bone marrow stem cells

Biotechnology Journal, 2021
Mechanical stimulation plays in an important role in regulating stem cell differentiation and their release of extracellular vesicles (EVs). In this study, effects of low magnitude hydrostatic pressure (HP) on the chondrogenic differentiation and ...
Lu Luo, N. Foster, Kenny Man, Mathieu Y. Brunet, D. Hoey, S. Cox, S. Kimber, A. E. Haj   +7 more
semanticscholar   +1 more source

Endothelial Progenitor Cell-Derived Microvesicles Promote Angiogenesis in Rat Brain Microvascular Endothelial Cells In vitro

Frontiers in Cellular Neuroscience, 2021
Brain microvascular endothelial cells (BMECs) are a major component of the blood-brain barrier that maintains brain homeostasis. Preserving and restoring the normal biological functions of BMECs can reverse or reduce brain injury.
Wen Zeng, Qiaoling Lei, Jiao Ma, Shuqiang Gao, Rong Ju   +4 more
doaj   +1 more source

Circulating Thrombomodulin: Release Mechanisms, Measurements, and Levels in Diseases and Medical Procedures

TH Open, 2022
Thrombomodulin (TM) is a type-I transmembrane protein that is mainly expressed on endothelial cells and plays important roles in many biological processes. Circulating TM of different forms are also present in biofluids, such as blood and urine.
Mallorie Boron, Tiffany Hauzer-Martin, Joseph Keil, Xue-Long Sun   +3 more
doaj   +1 more source