Results 91 to 100 of about 15,195 (308)

The role of microvesicles in tissue repair [PDF]

Organogenesis, 2011
Microvesicles (MVs) are released by almost all cells in resting and activated conditions. First described several years ago, it is only recently that their mechanisms of action are being elucidated, and their potential role in health and disease is drawing increasing attention.
Maria Chiara Deregibus, Stefania Bruno, Giovanni Camussi, Ciro Tetta, Valentina Fonsato   +4 more
openaire   +3 more sources

Extracellular microvesicle microRNAs as predictive biomarkers for targeted therapy in metastastic cutaneous malignant melanoma

PLoS ONE, 2018
Background Mitogen activated-protein kinase pathway inhibitors (MAPKis) improve treatment outcome in patients with disseminated BRAFV600 mutant cutaneous malignant melanoma (CMM) but responses are of limited duration due to emerging resistance.
F. Svedman, W. Lohcharoenkal, M. Bottai, S. E. Brage, E. Sonkoly, J. Hansson, A. Pivarcsi, H. Eriksson   +7 more
semanticscholar   +1 more source

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction

Advanced Science, EarlyView.
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED‐ApoVs) in the treatment of CD8+ T cell‐mediated hypersensitivity reactions is noteworthy. SHED‐ApoVs are capable of fusing with the plasma membrane of CD8+ T cells, which subsequently triggers a series of events characterized by calcium overload ...
Anqi Liu, Peng Peng, Changze Wei, Fanhui Meng, Xiaoyao Huang, Peisheng Liu, Siyuan Fan, Xinyue Cai, Meiling Wu, Zilin Xuan, Qing Liu, Xinyu Qiu, Zhenlai Zhu, Hao Guo   +13 more
wiley   +1 more source

Matrix stiffness regulates microvesicle-induced fibroblast activation.

American Journal of Physiology - Cell Physiology, 2019
Extracellular vesicles released by cancer cells have recently been implicated in the differentiation of stromal cells to their activated, cancer-supporting states.
S. C. Schwager, François Bordeleau, Jian Zhang, M. Antonyak, R. Cerione, Cynthia A. Reinhart-King   +5 more
semanticscholar   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

Lymphatic and Blood Endothelial Extracellular Vesicles: A Story Yet to Be Written

Life, 2022
Extracellular vesicles (EVs), such as exosomes, microvesicles, and apoptotic bodies, are cell-derived, lipid bilayer-enclosed particles mediating intercellular communication and are therefore vital for transmitting a plethora of biological signals.
Johanna Trisko, Johanna Fleck, Silvio Kau, Johannes Oesterreicher, Wolfgang Holnthoner   +4 more
doaj   +1 more source

The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding

Cell Death and Disease, 2019
Fas-associated death domain (FADD) is a key adaptor molecule involved in numerous physiological processes including cell death, proliferation, innate immunity and inflammation. Therefore, changes in FADD expression have dramatic cellular consequences. In
Sara Mouasni, V. Gonzalez, A. Schmitt, Evangéline Bennana, F. Guillonneau, S. Mistou, J. Avouac, H. Ea, V. Devauchelle, J. Gottenberg, G. Chiocchia, L. Tourneur   +11 more
semanticscholar   +1 more source

Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury

Advanced Science, EarlyView.
Based on the biodegradability and the immunological reactiveness, IMNs can be broadly classified into four categories. The first category includes types of biologically derived materials that cause immunomodulatory action and biodegradability like nanoparticles of cell membranes, extracellular vesicles, and exosomes.
Chenli Zhang, Zeli Xiang, Pengfei Yang, Ling Zhang, Jun Deng, Xiaohui Liao   +5 more
wiley   +1 more source

MicroRNA-124 slows down the progression of Huntington′s disease by promoting neurogenesis in the striatum

Neural Regeneration Research, 2015
MicroRNA-124 contributes to neurogenesis through regulating its targets, but its expression both in the brain of Huntington′s disease mouse models and patients is decreased.
Tian Liu, Wooseok Im, Inhee Mook-Jung, Manho Kim   +3 more
doaj   +1 more source

Microglial microvesicle secretion and intercellular signaling [PDF]

Frontiers in Physiology, 2012
Microvesicles (MVs) are released from almost all cell brain types into the microenvironment and are emerging as a novel way of cell-to-cell communication. This review focuses on MVs discharged by microglial cells, the brain resident myeloid cells, which comprise ∼10-12% of brain population.
Elena eTurola, Elena eTurola, Roberto eFurlan, Fabio eBianco, Michela eMatteoli, Michela eMatteoli, Michela eMatteoli, Claudia eVerderio, Claudia eVerderio   +8 more
openaire   +6 more sources