Results 91 to 100 of about 11,054 (241)
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source
The role of exosomes in peripheral nerve regeneration
Neural Regeneration Research, 2015 Peripheral nerve injuries remain problematic to treat, with poor functional recovery commonly observed. Injuries resulting in a nerve gap create specific difficulties for axonal regeneration.
Rosanna C Ching, Paul J Kingham
doaj +1 more source
Lymph Node‐Targeted Nanomaterials for Controlled Nano‐Immunotherapy
Small Structures, EarlyView.This study primarily investigates lymph node‐targeted immunotherapeutic strategies, focusing on the mechanisms of immune response regulation within lymph nodes. By targeting distinct immune signaling pathways, we systematically explore the development of nanodrug delivery systems specifically designed for lymph node targeting to achieve enhanced ...
Yitong Zhao +4 more
wiley +1 more source
Andrology, EarlyView.ABSTRACT Background Asthenozoospermia is a significant contributing factor to male infertility. Accumulating evidence indicates that impaired sperm motility is closely linked to dysregulated microRNA expression during spermatogenesis. Seminal plasma exosomes are enriched with diverse microRNAs, which play pivotal roles in modulating sperm motility, the
Zhi‐Jian Zhu +8 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2016 Unconventional secretion and subsequent uptake of molecular cargo via extracellular vesicles (EVs) is an important mechanism by which cells can exert paracrine effects.
Daniel J Schneider +3 more
doaj +1 more source
Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation
Cell Proliferation, EarlyView.Mechanical tension activates Drp1‐mediated mitochondrial fission in macrophages, facilitating the release of Mito‐EVs that are subsequently transferred to BMSCs. Additionally, the CD200R‐CD200 interaction enhances the uptake of these mechanically stimulated macrophage‐derived Mito‐EVs by BMSCs, ultimately promoting osteogenic differentiation.
Yingyi Li +8 more
wiley +1 more source
The FEBS Journal, EarlyView.Intracellular communication controls the processing of generated signals so that every cell type can successfully respond. The extracellular matrix (ECM) is a fundamental regulator of cell communication and signaling through the strict orchestration and functions of its bioactive components.
Zoi Piperigkou +6 more
wiley +1 more source
Strategies for enumeration of circulating microvesicles on a conventional flow cytometer [PDF]
, 2018 Mohammad J. Alkhatatbeh +6 more
openalex +1 more source
International Journal of Dermatology, EarlyView.ABSTRACT Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell‐based therapies.
Marcela da Costa Pereira Cestari +2 more
wiley +1 more source