Results 91 to 100 of about 15,493 (301)
Background Mitogen activated-protein kinase pathway inhibitors (MAPKis) improve treatment outcome in patients with disseminated BRAFV600 mutant cutaneous malignant melanoma (CMM) but responses are of limited duration due to emerging resistance.
F. Svedman+7 more
semanticscholar +1 more source
Extracellular matrix remodeling is crucial in cancer progression. Using a peptide to probe the tension of ECM fibers, it was found that Fibronectin fibers gradually lose tension as human breast carcinoma progresses, while their tension is maintained in ductal carcinoma in situ (DCIS), the non‐invasive precursor of breast cancer. This loss of tension is
Arnaud Miéville+6 more
wiley +1 more source
Microvesicles and intercellular communication in the context of parasitism [PDF]
There is a rapidly growing body of evidence that production of microvesicles (MVs) is a universal feature of cellular life. MVs can incorporate microRNA (miRNA), mRNA, mtDNA, DNA and retrotransposons, camouflage viruses/viral components from immune surveillance, and transfer cargo between cells.
Natasha S. Barteneva+4 more
openaire +4 more sources
Endothelial cells release microvesicles that harbour multivesicular bodies and secrete exosomes
Extracellular vesicles (EVs) released by endothelial cells support vascular homeostasis. To better understand endothelial cell EV biogenesis, we examined cultured human umbilical vein endothelial cells (HUVECs) prepared by rapid freezing, freeze ...
Jennifer D. Petersen+4 more
doaj +1 more source
Matrix stiffness regulates microvesicle-induced fibroblast activation.
Extracellular vesicles released by cancer cells have recently been implicated in the differentiation of stromal cells to their activated, cancer-supporting states.
S. C. Schwager+5 more
semanticscholar +1 more source
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen+12 more
wiley +1 more source
Extracellular vesicles: Exosomes, microvesicles, and friends [PDF]
Cells release into the extracellular environment diverse types of membrane vesicles of endosomal and plasma membrane origin called exosomes and microvesicles, respectively. These extracellular vesicles (EVs) represent an important mode of intercellular communication by serving as vehicles for transfer between cells of membrane and cytosolic proteins ...
Graça Raposo+2 more
openaire +3 more sources
Ligustrazine monomer against cerebral ischemia-reperfusion injury
Ligustrazine (2,3,5,6-tetramethylpyrazine) is a major active ingredient of the Szechwan lovage rhizome and is extensively used in treatment of ischemic cerebrovascular disease.
Hai-jun Gao+9 more
doaj +1 more source
Development of drug resistance in cancer has major implications for patients’ outcome. It is related to processes involved in the decrease of drug efficacy, which are strongly influenced by intratumor heterogeneity and changes in the microenvironment ...
A. Álvarez-Arenas+4 more
semanticscholar +1 more source
This study reveals that M2‐EVs mitigate periodontitis‐induced bone resorption by modulating neutrophil fate. Single‐cell RNA sequencing identified an Anxa1hi neutrophil subpopulation with pro‐reparative properties. M2‐EVs disrupt neutrophil maturation, promoting this subpopulation through key reprogramming genes (Acvrl1, Fpr2). These findings highlight
Yufei Yao+7 more
wiley +1 more source